CAS: 104-93-8; 1-Methoxy-4-Methylbenzene

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100-84-5 1515-95-3 768-60-5

上下游产品

CAS号123-11-5 4-甲氧基苯甲醛; 对甲氧基苯... | CAS号824-94-2 4-甲氧基苄氯 | CAS号105-13-5 对甲氧基苄醇 | CAS号874-90-8 4-甲氧基苯甲腈 | CAS号104-47-2 对甲氧基苯乙腈 | CAS号106-44-5 对甲酚 | CAS号74-88-4 碘甲烷 | CAS号6258-60-2 4-甲氧基苄硫醇 | CAS号4637-24-5 N,N-二甲基甲酰胺二甲基缩醛 | CAS号70744-47-7 三丁基-(4-甲氧基-苯基)-锡烷 | CAS号107430-92-2 3-(叔丁基)-4-甲氧基苯甲醛 | CAS号527-54-8 3,4,5-三甲基苯酚 | CAS号95-65-8 3,4-二甲酚 | CAS号106-44-5 对甲酚 | CAS号5335-87-5 4,4'-二甲氧基二苯二硫醚 | CAS号1370435-75-8 (1-(4-chlorophe... | CAS号169059-34-1 (1-(4-chlorophe... | CAS号108-98-5 硫酚 | CAS号3597-91-9 4-联苯甲醇

4-甲氧基氯苄置于四(三苯基膦)钯 Diethylzinc体系中,用 正己烷,N,N-二甲基甲酰胺 用作溶剂,化学反应 1.0H,以95%的收率获得对甲苯甲醚
参考文献:Reduction Of Benzylic Halides With Diethylzinc Using Tetrakis(Triphenylphosphine)Palladium As Catalyst
标题:Reduction Of Benzylic Halides With Diethylzinc Using Tetrakis(Triphenylphosphine)Palladium As Catalyst
摘要:
Doi:10.1021/jo00076A066

专利信息

专利号:US-9446995-B2
优先权日:2012-05-21
标 题:Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
发明人：CHONG HYUN-SOON
权利人:CHONG HYUN-SOON; ILLINOIS INST OF TECH
摘要:Stereoselective and regioselective synthesis of compounds via nucleophilic ring opening reactions of aziridinium ions for use in stereoselective and regioselective synthesis of therapeutic and diagnostic compounds.

专利号:US-10189803-B2
优先权日:2008-02-22
标题 :Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
发明人：CHONG HYUN-SOON
权利人:CHONG HYUN SOON; ILLINOIS INSTITUTE OF TECH
摘要:Stereoselective and regioselective synthesis of compounds via nucleophilic ring opening reactions of aziridinium ions for use in stereoselective and regioselective synthesis of therapeutic and diagnostic compounds.

专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人：KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

专利号:US-2008032964-A1
优先权日:2006-04-10
标题:Process for the synthesis of azetidinone
发明人：KANSAL VINOD K; AHMAD SUHAIL; MARIAPPAN SHANMUGAVEL; TYAGI BHUPENDRA; PERLMAN NURIT; LE PAIH JACQUES; ZANOTTI-GEROSA ANTONIO
权利人:KANSAL VINOD K; AHMAD SUHAIL; MARIAPPAN SHANMUGAVEL; TYAGI BHUPENDRA; PERLMAN NURIT; LE PAIH JACQUES; ZANOTTI-GEROSA ANTONIO
摘要:Provided are intermediates useful for the synthesis of hydroxyl-alkyl substituted azetidinones, processes of their preparation, and processes for the synthesis of certain hydroxyl-alkyl substituted azetidinones. Also provided are processes for the synthesis of 1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone, or ezetimibe.

专利号:US-2022395800-A1
优先权日:2019-11-04
标题:Device for automated synthesis of oligo- and polysaccharides
发明人：SEEBERGER PETER H; DANGLAD FLORES JOSE; LE MAI HOANG KIM; PARDO VARGAS ALONSO; SLETTEN ERIC; SALWICZEK MARIO
权利人:MAX PLANCK GESELLSCHAT ZU RFERDERUNG DER WSS E V; GlycoUniverse GmbH & Co KG&A
摘要:The present invention generally relates to automated synthesis technology, and more particularly, to a device and method for automated synthesis of oligo- and polysaccharides on a solid support. In particular the present invention relates to a device for automated synthesis of oligo- and polysaccharides on a solid support comprising a reaction vessel, a reagent storing component, a reagent delivery system, a cooling device for cooling reaction vessel, and a pre-cooling device for pre-cooling the reagents to be supplied.

专利号:US-7183417-B2
优先权日:2004-04-09
标题:Simple stereocontrolled synthesis of salinosporamide A
发明人：COREY ELIAS J
权利人:HARVARD COLLEGE
摘要:A simple and effective stereocontrolled synthesis of salinosporamide A(1) n nhas been developed which follows the pathway outlined in the FIGURE. The process, the first total synthesis of salinosporamide A, is capable of providing the compound in substantial quantities for further biological studies. In addition to the method of Scheme I, the present invention also includes several novel synthetic intermediate compounds, several intermediate steps of the preferred synthetic process; and the uses of these compounds in the preparation of synthetic derivatives of the compound Salinosporamide A. Salinosporamide A is of special interest as a synthetic target because of its protein in vitro cytotoxic activity against many tumor cell lines (IC 50 values of 10 nM or less).