CAS: 116169-90-5; (S)-2-(((S)-1-Ethoxy-1-Oxo-4-Phenylbutan-2-yl)Amino)-6-(2,2,2-Trifluoroacetamido)Hexanoic Acid

相似化合物

82717-96-2 162358-08-9 130414-30-1

上下游产品

ethyl (R)-2-hydroxy-4-phenylbutyrateε-(trifluoroacetyl)-Nα--L-lysyl-L-prolineNε-(trifluoroacetyl)-Nα-(S)-1-(ethoxycarbonyl)-3-phenylpropyl-L-lysyl-L-proline

N2-[1-(S)-Ethoxycarbonyl-3-Oxo-3-Phenylpropyl]-N6-Trifluoroacetyl-L-Lysine 反应生成N2-(1-乙氧羰基-3-苯丙基)-N6-三氟乙酰基-L-赖氨酸
参考文献:Yamada,Kadzuxiko;Inoueh,Kehnuzi;Takaxasi,Satomi;Oxasi,Takehxisa;Vatan+
标题:Yamada,Kadzuxiko;Inoueh,Kehnuzi;Takaxasi,Satomi;Oxasi,Takehxisa;Vatan+

专利信息

专利号:US-10633329-B2
优先权日:2016-11-17
标题 :Method for preparing lisinopril intermediate
发明人：WANG SONGQING; DONG PENG; ZHENG YANG; LI QUANJUN
权利人:ZHEJIANG HUAHAI PHARM CO LTD; ZHEJIANG HUAHAI TIANCHENG PHARMACEUTICALS CO LTD; ZHEJIANG HUAHAI LICHENG PHARMACEUTICALS CO LTD; ZHEIJIANG HUAHAI TIANCHENG PHARMACEUTICALS CO LTD
摘要:A method for preparing a lisinopril intermediate is provided. The method includes: treating (R)-hydroxy-4-phenylbutyrate with sulfonyl chloride in an organic solvent in the presence of a base to obtain a solution of sulfonate; reacting the obtained solution with a salt of trifluoroacetyl lysine; and obtaining a N 2 -[1-(S)-alkoxycarbonyl-3-phenylpropyl]-N 6 -trifluoroacetyl-L-lysine by separating after the reaction is completed. The method provided has a shorter synthesis route, is easy to operate, has a low cost, and is suitable for industrial production.