CAS: 1425-61-2; 2,2'-((1R,2R,3S,4R,5R,6S)-4-(((2R,3R,4R,5S)-3-(((2S,3S,4S,5R,6S)-4,5-Dihydroxy-6-(Hydroxymethyl)-3-(Methylamino)Tetrahydro-2H-Pyran-2-yl)Oxy)-4-Hydroxy-4-(Hydroxymethyl)-5-Methyltetrahydrofuran-2-yl)Oxy)-2,5,6-Trihydroxycyclohexane-1,3-Diyl)Diguanidine Sulfate

硫酸链霉素置于sodium Tetrahydroborate,三乙胺,硫酸体系中,用 水 用作溶剂,以10.5 G的收率获得硫酸双氢链霉素
参考文献:链霉素的实际合成和 (−)-(1R,2S,3R,4R,5S,6S)-1,3-二(脱氨基)-1,3-二叠氮基-2,5,6-三-的区域选择性部分脱保护邻苄链霉胺
标题:链霉素的实际合成和 (−)-(1R,2S,3R,4R,5S,6S)-1,3-二(脱氨基)-1,3-二叠氮基-2,5,6-三-的区域选择性部分脱保护邻苄链霉胺
摘要:我们描述了 (−)-(1 R,2 S,3 R,4 R,5 S,6 S )-1,3-Di(Diamino)-1,3-Diazido-2,5 的克级合成通过 (I) 水解两个链霉素胍残基,(II) 将胺重新保护为叠氮化物,(III) 将所有醇保护为苄基醚,以及 (Iv) 糖苷键断裂,从链霉素中得到,6-三-O-苄基链霉胺与 Hcl 的甲醇溶液反应.还描述了产品中单一叠氮化物的区域选择性单脱苄基化和区域选择性还原的方案,为新型氨基糖苷合成中的开发提供了四种光学纯的构建模块.
Doi:10.1021/acs.Joc.3C02922

专利信息

专利号:WO-2009056955-A1
优先权日:2007-10-30
标题 :Amine-bearing phospholipids (abps), their synthesis and use
发明人：ZUMBUEHL ANDREAS
权利人:UNIV BASEL; ZUMBUEHL ANDREAS
摘要:Disclosed herein are amine-bearing phospholipids (ABP). The ABPs display many properties and functionalities of naturally occurring phospholipids, but also new properties and functionalities, such as the ability to polymerize while maintaining structural integrity, that may supplement or expand the functionalities of naturally occurring phospholipids.

专利号:US-2014315720-A1
优先权日:2012-10-24
标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
发明人：FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
权利人:CELANESE ACETATE LLC
摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.