CAS: 14339-33-4; 3-Chloro-1H-Pyrazole

该化合物是一种环环有机化合物,其特点是在三点方位用氯原子取代一个环形环,这种多用途中间体由于其反应性化的氯组而广泛用于制药和农用化学合成,有利于进一步的功能化,其稳定的芳香结构确保其与一系列反应条件相容,使其对制造复杂分子很有价值.该化合物的高度纯度和一贯质量对于药用化学应用至关重要,因为它是生物活性化合物的关键建筑.其明确界定的化学特性和合成可靠性强调了其在工业和研究环境中的重要性.

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相似化合物

15953-45-4 27258-18-0 50877-39-9

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上下游产品

3-Chlor-4-trimethylsilylpyrazol 5-chloro-N,N-dimethyl-1H-pyrazole-1-sulfonamide 3-chloro-N,N-dimethyl-1H-pyrazole-1-sulfonamide 3-aminopyrazole 3-chloro-2-(3-chloro-1H-pyrazol-1-yl)pyridine

合成工艺路线路线简述

    1-苯磺酰吡唑置于正丁基锂,六氯乙烷,Sodium Methylate体系中,用 四氢呋喃,甲醇 用作溶剂,化学反应 2.92H,以21%的收率获得3-氯-1H-吡唑
    参考文献:Wo2007/45868
    标题:Wo2007/45868

    专利信息


    专利号:US-9901901-B2
    优先权日:2012-05-21
    标 题 :Selective extraction of anions from solution
    发明人:MEZEI GELLERT
    权利人:WESTERN MICHIGAN UNIV RESEARCH FOUNDATION; THE BOARD OF TRUSTEES OF WESTERN MICHIGAN UNIV
    摘要:A method of selectively extracting anions from an aqueous solution using an anion encapsulating aggregate formed upon the addition of a solvent, a copper contributor, a hydroxide contributor, a counterion contributor, and pyrazole to an aqueous solution containing the anions, or upon the addition of a solvent, a polymeric chain of [Cu II (μ-OH)(μ-pz)] ∞ and a counterion contributor to the aqueous solution. The aggregates include compounds of the formula cis Cu II x (OR 1 ) y (R 2 pz) z , where R 1 is H or an alkyl group, R 2 is H, or an alkyl group or a charged group, pz is pyrazolate and each of x, y, and z is an integer between about 1 and about 40. In addition, ligand-containing anion encapsulating aggregates can be formed by synthesis with a lig-and-bound pyrazole or by substituting the ligand-bound pyrazole for the pyrazole incorporated in the aggregate.

    专利号:US-10087197-B2
    优先权日:2012-05-21
    标 题:Selective extraction of anions from solution
    发明人:MEZEI GELLERT
    权利人:WESTERN MICHIGAN UNIV RESEARCH FOUNDATION
    摘要:A method of selectively extracting anions from an aqueous solution using an anion encapsulating aggregate formed upon the addition of a solvent, a copper contributor, a hydroxide contributor, an optional counterion contributor, and at least one encapsulating anion to an aqueous solution containing the anions, or upon the addition of a solvent, a polymeric chain of [CuII(μ-OH)(μ-ea)]∞ and optionally, a counterion contributor to the aqueous solution. The aggregates include compounds of the formula cis-CuIIx(OR1)y(R2ea)z, where R1 is H or an alkyl group, R2 is H, or an alkyl group or a charged group, ea is an encapsulating anion, and each of x, y, and z is equal to an integer between about 1 and 40, inclusive. In addition, anion encapsulating aggregates can be formed by synthesis with alternate encapsulating anions by substituting alternate encapsulating anions for the encapsulating anion incorporated in the aggregate.

    专利号:US-2024360125-A9
    优先权日:2021-02-22
    标 题 :2-substituted bicyclo[1.1.1]pentanes
    发明人:MACMILLAN DAVID W; GARRY OLIVIA L; LIANG YUFAN; HEILMANN MICHAEL
    权利人:UNIV PRINCETON
    摘要:Provided herein are 2-substituted bicyclo[1.1.1]pentane (BCP) compounds, as well as methods of making the 2-substituted BCP compounds and methods of derivatizing the 2-substituted BCP compounds, particularly at the 2-position. The 2-substituted BCP compounds described herein are useful building blocks in the synthesis of a variety of products, including pharmaceuticals, polymers, liquid crystals, monolayers and supramolecular structures.

    专利号:US-9815842-B2
    优先权日:2014-05-28
    标题 :Pyrazolo pyrimidine derivatives and their use as MALT1 inhibitors
    发明人:SOLDERMANN CAROLE PISSOT; QUANCARD JEAN; SCHLAPBACH ACHIM; SIMIC OLIVER; TINTELNOT-BLOMLEY MARINA; ZOLLER THOMAS
    权利人:SOLDERMANN CAROLE PISSOT; QUANCARD JEAN; SCHLAPBACH ACHIM; SIMIC OLIVER; TINTELNOT-BLOMLEY MARINA; ZOLLER THOMAS; NOVARTIS AG
    摘要:The present invention describes new pyrazolo-pyrimidine derivatives which are generally interacting with MALT1 proteolytic and/or autoproteolytic activity, and in particular which may inhibit said activity. The present invention further describes the synthesis of said new pyrazolo-pyrimidine derivatives, their use as a medicament, especially by interacting with MALT1 proteolytic and/or autoproteolytic activity.

    专利号:US-6545033-B1
    优先权日:1999-10-06
    标 题:Fused 1-(2,6-dichloro-4-trifluoromethylphenyl)-pyrazoles, the synthesis thereof and the use thereof as pesticides
    发明人:DHANOA DALJIT S; MEEGALLA SANATH; SOLL RICHARD M; DOLLER DARIO; SHA DEYOU; LIU RUIPING; SILVER GARY; LEE YU-KAI
    权利人:DIMENSIONAL PHARM INC
    摘要:The present invention is directed to novel pyrazole derivatives and their use as pesticidal agents. The pyrazole derivatives have Formula I:or a salt thereof, whereR1 is amino, hydrogen, alkyl, hydroxy, halo, alkoxy, alkylamino, dialkylamino, alkylthio, alkylsulfinyl, alkylsulfonyl, trifluoroalkylsulfinyl, trifluoroalkylsulfonyl, hydroxy, amino, trifluoromethyl, acetylamino, -OSO2R2, -OS(O)R2, -OC(O)R2, -OC(O)NHR2, or -NHC(O)NHR2 where R2 is C1-4 alkyl or optionally substituted aryl;X, Y and Z are each independently (CH)n, (CR3R4)n, S, S(O), or SO2, wherein n is 1-2, R3 and R4 are defined herein;Q is N or C-R6, wherein R6 is fluoro, chloro, bromo, or iodo;R5 is halo, C1-C6 alkyl, C1-C4 alkenyl, C1-C4 alkoxy, C1-C4 alkylamino, C1-C4 dialkylamino, C1-C4 alkylthio, C1-C4 alkylsulfinyl, C1-C4 alkylsulfonyl, C1-C4 trifluoroalkylsulfinyl, C1-C4 trifluoroalkylsulfonyl, hydroxy, amino, or trifluoromethyl; andwith the proviso that only one of X, Y and Z can be S, S(O) or SO2.

    专利号:DD-241413-A1
    优先权日:1985-10-02
    标 题:PROCESS FOR SYNTHESIS OF 4-ARYLHYDRAZONO-PYRAZOL-5-THIONES
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    合成参考文献


    摘要:J. Elguero, E. Gonzalez and R. Jacquier. Bull. Soc. Chim. France 1968, 5009.
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