CAS: 16343-08-1; Hexylboronic Acid

相似化合物

86308-26-1 28741-08-4 3088-79-7

上下游产品

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Hexylborsaeure-Dimethylester置于硫酸体系中,用 乙醚 用作溶剂,化学反应 0.33H,以5.69 G的收率获得正己基硼酸
参考文献:(-)-Microcarpalide,一种新型的微丝破坏代谢产物的全合成.
标题:(-)-Microcarpalide,一种新型的微丝破坏代谢产物的全合成.
摘要:立体选择性的全合成(-)-微果皮苷,一种最近发现的真菌来源的10元内酯,对肌动蛋白微丝具有显着的破坏作用,是通过使用闭环复分解(rcm)作为形成该蛋白的关键步骤而完成的.中型戒指.大环化反应所需的二烯酯是通过dcc介导的两个合适配偶体的酯化反应组装而成的,每个配偶体均带有一个末端烯基.醇片段是由正溴乙烷通过七步序列合成的,该序列需要两个连续的手性硼酸酯的立体选择性同系物作为将两个立体中心以最终s绝对构型顺序插入的战略转化,并使用(+)-Pin二醇作为手性导演 对所需的c(11)框架进行最终精制,设想使用烯丙基格利雅试剂进行处理,并对硼支架进行氧化裂解.相比之下,酸性片段是从d-酒石酸中分十步制备的,它的c(4)骨架通过两个不同的swern-Wittig氧化-同源序列被拉长至所需的c(7)骨架.
Doi:10.1039/b308709C

专利信息

专利号:US-9862745-B2
优先权日:2004-03-30
标题 :Synthesis of boronic ester and acid compounds
发明人：AMMOSCATO VINCE; BISHOP JOHN E; CHIU FANG-TING; GEISER ACHIM; GOMEZ JEAN-MARC; HETT ROBERT; KOELLNER CHRISTOPH; KULKARNI VITHALANAND R; LO YOUNG; MUNK STEPHEN; PICKERSGILL I FRASER
权利人:MILLENNIUM PHARM INC; MILLENNIUM PHARM INC
摘要:The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.

专利号:US-9243004-B2
优先权日:2011-07-22
标题 :Synthesis of boronic esters and boronic acids using grignard reagents
发明人：CLARY JACOB W; SINGARAM BAKTHAN
权利人:CLARY JACOB W; SINGARAM BAKTHAN; UNIV CALIFORNIA
摘要:Boronic esters and boronic acids are synthesized at ambient temperature in an ethereal solvent by the reaction of Grignard reagents with a boron-containing substrate. The boron-containing substrate may be a boronic ester such as pinacolborane, neopentylglycolborane, or a dialkylaminoborane compound such as diisopropylaminoborane. The Grignard reagents may be pre-formed or generated from an alkyl, alkenyl, aryl, arylalkyl, heteroaryl, vinyl, or allyl halide compound and Mg 0 . When the boron-containing substrate is a boronic ester, the reactions generally proceed at room temperature without added base in about 1 to 3 hours to form a boronic ester compound. When the boron-containing substrate is a dialkylaminoborane compound, the reactions generally proceed to completion at 0° C. in about 1 hour to form a boronic acid compound.

专利号:US-8207337-B2
优先权日:2007-01-29
标 题:Reagent for organic synthesis reaction containing organic triol borate salt
发明人：MIYAURA NORIO; YAMAMOTO YASUNORI
权利人:MIYAURA NORIO; YAMAMOTO YASUNORI; WAKO PURE CHEM IND LTD
摘要:[Problem] n To provide an organoboron compound-containing reagent for organic synthesis reactions which undergoes no trimerization with dehydration, does not necessitate activation with a base, and is stable and highly active. n [Means for Solving Problems] n The reagent for organic synthesis reactions contains an organic triol borate salt represented by any of the general formulae (I) to (III) and general formula (XVI): (wherein R 1 represents alkyl, alkenyl, etc.; R 2 represents optionally substituted alkyl, alkenyl, alkynyl, etc. or represents hydrogen; m + represents an alkaline metal ion, phosphonium ion, or given ammonium ion; M 2+ represents an alkaline earth metal; X represents halogen or alkoxide; Y represents an alkali metal ion, etc.; A represents optionally substituted methylene; and n represents an integer).

专利号:US-2018265546-A1
优先权日:2004-03-30
标题 :Synthesis of boronic ester and acid compounds

专利号:US-2005240047-A1
优先权日:2004-03-30
标 题:Synthesis of boronic ester and acid compounds

专利号:US-2020157143-A1
优先权日:2004-03-30
标题 :Synthesis of boronic ester and acid compounds