CAS: 170791-09-0; 1-(((Cyclohexyloxy)Carbonyl)Oxy)Ethyl 2-Ethoxy-1-((2'-(1-Trityl-1H-Tetrazol-5-yl)-[1,1'-Biphenyl]-4-yl)Methyl)-1H-Benzo[d]Imidazole-7-Carboxylate

上下游产品

CAS号139481-72-4 三苯甲基坎地沙坦 | CAS号99464-83-2 1-氯乙基环己基碳酸酯 | CAS号1239349-15-5 1-(cyclohexylox... | CAS号76-83-5 三苯基氯甲烷 | CAS号145040-37-5 坎地沙坦酯 | CAS号139481-59-7 坎地沙坦 | CAS号145040-37-5 坎地沙坦酯 | CAS号869631-11-8 O-去乙基坎地沙坦

坎地沙坦置于potassium Carbonate,三乙胺体系中,用 二氯甲烷,N,N-二甲基甲酰胺 用作溶剂,化学反应 6.25H,反应生成三苯甲基坎地沙坦西来替昔酯
参考文献: An Improved Process For The Preparation Of Candesartan Cilexetil,Polymorphic Forms Of N-Trityl Candesartan And Their Uses Thereof[fr] Procede Ameliore De Preparation De Candesartan Cilexetil,Formes Polymorphes De N-Trityl Candesartan Et Leurs Utilisations
标题: An Improved Process For The Preparation Of Candesartan Cilexetil,Polymorphic Forms Of N-Trityl Candesartan And Their Uses Thereof[fr] Procede Ameliore De Preparation De Candesartan Cilexetil,Formes Polymorphes De N-Trityl Candesartan Et Leurs Utilisations
摘要:本发明提供了一种改进的卡地沙坦西乐沙替制备工艺,包括使用n-三苄基卡地沙坦的多形式a和多形式b.此外,本文提供了新的n-三苄基卡地沙坦多形式a和多形式b以及它们的制备工艺.

专利信息

专利号:US-2008214637-A1
优先权日:2004-11-11
标题 :Process for the Synthesis of Tetrazoles
发明人：ANTONCIC LJUBOMIR; LUDESCHER JOHANNES
权利人:LEK PHARMACEUTICALS
摘要:A process for the synthesis of tetrazol derivative has been developed which starts from a tetrazole derivative where acidic hydrogen atom has been replaced by a protecting group and the deprotection is performed with a catalytic amount of organic acid and can proceed in an aqueous solvent.

专利号:US-7098342-B2
优先权日:2003-10-16
标题 :Preparation of candesartan cilexetil
发明人：ETINGER MARINA YU; FEDOTEV BORIS; DOLITZKY BEN-ZION
权利人:TEVA PHARMA
摘要:The invention encompasses processes for the synthesis of cilexetil trityl candesartan from the reaction of trityl candesartan with cilexetil halide in the presence of a base and a low boiling organic solvent. Optionally, the reaction may be conducted in the presence of a phase transfer catalyst.