CAS: 33821-94-2; 2-(3-Bromopropoxy)Tetrahydro-2H-Pyran

该化合物是一种有机化合物,其特征是四氢呋喃结构,包括一个环状环;一个溴丙氧化合物组的存在既具有卤素功能,又具有一种醚的功能,影响其反应性和溶性;该化合物一般由于溴原子和醚联系而呈现中度极性,这可能会影响其与其他分子的相互作用;溴基替代成分也可以作为核分裂替代反应的场所,使其在有机合成中成为有用的中间体;此外,四氢丙烯环有助于该化合物的稳定,并能够参与各种化学反应,例如环状开裂或功能化;其物理特性,例如沸点和溶性,将取决于特定条件和其他功能组的存在;

结构式图片

相似化合物

627-18-9 31608-22-7 53963-10-3

欧盟法规

ECHA物质C&L通报

上下游产品

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合成工艺路线路线简述

    2-Propoxy-Tetrahydro-Pyran置于四溴化碳,三苯基膦体系中,化学反应生成2-(3-溴丙氧基)四氢-2H-吡喃
    参考文献:Functionalized Aliphatic P2/p2' Analogs Of Hiv-1 Protease Inhibitor Dmp323
    标题:Functionalized Aliphatic P2/p2' Analogs Of Hiv-1 Protease Inhibitor Dmp323
    摘要:A Series Of Analogs Of Hiv Protease Inhibitor Dmp323 Containing Functionalized Aliphatic P2/p2' Groups Was Prepared And Evaluated For Hn Protease Inhibition And Antiviral Activity In A Cell-Based Assay. Asymmetric Compounds With A 5-Hydroxypentyl Substituent At P2 And A Benzylic Substituent At P2' Showed Increased Potency Over The Corresponding Symmetrically Substituted Analogs. (C) 1997 The Dupont Merck Pharmaceutical Company. Published By Elsevier Science Ltd.
    Doi:10.1016/s0960-894X(97)00165-0

    海关参考信息

    专利信息


    专利号:US-10793557-B2
    优先权日:2018-04-03
    标题 :Sting agonist compounds
    发明人:ALTMAN MICHAEL D; CASH BRANDON D; CHILDERS MATTHEW LLOYD; CUMMING JARED N; DEMONG DUANE E; HAIDLE ANDREW MARC; HENDERSON TIMOTHY J; JEWELL JAMES P; LARSEN MATTHEW A; LIM JONGWON; LU MIN; OTTE RYAN D; TROTTER BENJAMIN WESLEY
    权利人:MERCK SHARP & DOHME
    摘要:Compounds of general formula (I), of general formula (II), of general formula (III), of general formula (IV), of general formula (V), of general formula (VI), and their pharmaceutically acceptable salts, wherein all variables are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are compositions comprising such compounds, processes for the synthesis of such compounds, and to uses of such compounds, including administration of such compounds to induce immune response, to induce STING-dependent type I interferon production, and/or to treat a cell proliferation disorder, such as cancer.

    专利号:WO-2024074814-A9
    优先权日:2022-10-04
    标题 :Composition comprising a functionalised dye and a diallylamine comonomer and use thereof
    发明人:CANNON PAUL; DONLEY ADAM; LAWRENCE ANTHONY; WRIGHT GAVIN; TURNER CARL; ROBERTS PHILIP
    权利人:SUBLINO LTD; COLOUR SYNTHESIS SOLUTIONS LTD
    摘要:The present teachings relate to a composition comprising a functionalised dye and a diallylamine comonomer, and the use of such compositions in methods of colouring a substrate. The present teachings provide improved bonding of a dye to a substrate, and preferably allow colouring to be conducted entirely in the presence of an aqueous solvent.

    专利号:US-6416861-B1
    优先权日:1999-02-16
    标题 :Organosilicon compounds and uses thereof
    发明人:LEE YOUNGHEE; SILVERMAN RICHARD B
    权利人:UNIV NORTHWESTERN
    摘要:A compound of the formula: n and a resin-bound compound of the formula: n and their use in combinatorial chemistry and in the synthesis of compounds comprising at least one aromatic moiety is described, where R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , L 1 , P, Ar 1 , and X are as herein defined.

    专利号:US-8129411-B2
    优先权日:2005-12-30
    标题:Organic compounds
    发明人:EHARA TAKERU; GROSCHE PHILIPP; IRIE OSAMU; IWAKI YUKI; KANAZAWA TAKANORI; KAWAKAMI SHIMPEI; KONISHI KAZUHIDE; MOGI MUNETO; SUZUKI MASAKI; YOKOKAWA FUMIAKI
    权利人:EHARA TAKERU; GROSCHE PHILIPP; IRIE OSAMU; IWAKI YUKI; KANAZAWA TAKANORI; KAWAKAMI SHIMPEI; KONISHI KAZUHIDE; MOGI MUNETO; SUZUKI MASAKI; YOKOKAWA FUMIAKI; NOVARTIS AG
    摘要:The invention relates to 3,5-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,5-substituted piperidine compound, and/or a method of treatment comprising administering a 3,5-substituted piperidine compound, a method for the manufacture of a 3,5-substituted piperidine compound, and novel intermediates and partial steps for its synthesis. n The compounds have the formula I′ n nwherein R1, R2, T, R3 and R4 are as defined in the specification.

    专利号:US-8178559-B2
    优先权日:2004-12-30
    标 题:Organic compounds
    发明人:BREITENSTEIN WERNER; EHARA TAKERU; EHRHARDT CLAUS; GROSCHE PHILIPP; HITOMI YUKO; IWAKI YUKI; KANAZAWA TAKANORI; KONISHI KAZUHIDE; MAIBAUM JUERGEN KLAUS; MASUYA KEIICHI; IWASAKI ATSUKO; OSTERMANN NILS; SUZUKI MASAKI; TOYAO ATSUSHI; YOKOKAWA FUMIAKI
    权利人:BREITENSTEIN WERNER; EHARA TAKERU; EHRHARDT CLAUS; GROSCHE PHILIPP; HITOMI YUKO; IWAKI YUKI; KANAZAWA TAKANORI; KONISHI KAZUHIDE; MAIBAUM JUERGEN KLAUS; MASUYA KEIICHI; IWASAKI ATSUKO; OSTERMANN NILS; SUZUKI MASAKI; TOYAO ATSUSHI; YOKOKAWA FUMIAKI; NOVARTIS AG
    摘要:3,4-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,4-substituted piperidine compound, and/or a method of treatment comprising administering a 3,4substituted piperidine compound, a method for the manufacture of a 3,4-substituted piperidine compound, and novel intermediates and partial steps for their synthesis are disclosed. The 3,4-disubstituted piperidine compounds have the formula (I), wherein the symbols have the meanings defined in the specification.

    专利号:RU-2198879-C2
    优先权日:1996-09-25
    标题:Derivatives of quinazoline, methods of their synthesis, pharmaceutical compositions comprising thereof, method of attainment of antiangiogenic effect and/or effect of blood vessel permeability reduction in warm-blooded animal
    嘉兴市吉拉特化工有限公司
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    合成参考文献


    摘要:Alonso, D. A.; Nájera, C., Science of Synthesis, (2010) 47, 455.
    摘要:Chciuk, T. V.; Flowers, R. A.; Flowers, R. A., Science of Synthesis Knowledge Updates, (2016) 2, 197.
    摘要:Kimura, T., Science of Synthesis Knowledge Updates, (2016) 2, 434.
    摘要:Mejuch, T.; Marek, I., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 1, 773.
    摘要:Pitaval, A.; Echavarren, A. M., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 1, 575.
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