CAS: 52340-78-0; (1R,2R)-1,2-Diphenylethane-1,2-Diol

上下游产品

CAS号134-81-6 联苯甲酰 | CAS号451-40-1 二苯乙酮 | CAS号103-30-0 反式-1,2二苯乙烯 | CAS号100-52-7 苯甲醛 | CAS号134-81-6 联苯甲酰 | CAS号119-53-9 2-羟基-2-苯基苯乙酮 | CAS号5928-66-5 (R)-(-)-苯偶姻 | CAS号29841-69-8 (1S,2S)-(-)-1,2... | CAS号153322-11-3 4-CHLORO-3-NITR... | CAS号23190-16-1 (1R,2S)-(-)-2-氨... | CAS号120850-92-2 (1R,2R)-(-)-1,2...

联苯甲酰置于bis(1,5-Cyclooctadiene)Diiridium(I) Dichloride,甲酸,(αr,2S)-(-)-1-(2-Diphenylphosphinobenzyl)-α-(2,2-Dimethylpropynyl)-2-Pyrrolidinemethanol,Potassium Carbonate体系中,化学反应 6.0H,以94%的收率获得产物氢胺
参考文献:酒精氢键和sp3-Ch非共价相互作用控制的铱催化的酮的对映选择性加氢
标题:酒精氢键和sp3-Ch非共价相互作用控制的铱催化的酮的对映选择性加氢
摘要:使用脯氨醇-膦手性配体开发了铱与甲酸的铱催化对映选择性转移氢化反应.铱原子与配体通过醇-醇盐相互转化的协同作用对于促进转移氢化至关重要.包括烷基芳基酮,酮酸酯和芳基杂芳基酮在内的各种酮是有效的底物.此催化的一个有吸引力的特征是酮的烷基和芳基取代基,促进与enantioselection的相同的有义氢化不管烷基取代基的空间位阻的需求,并因此导致高度对映选择性转移氢化的一种罕见的情况下之间的高效歧视叔-烷基芳基酮.量子化学计算表明sp 3-C-H / An之间π相互作用sp 3的脯氨醇-膦配位体的-C-H键和酮的芳基取代基是用于与o型h⋅⋅⋅o组合enantioselection关键/ Sp 3-手性配体与羰基之间存在chh.⋅⋅o两点氢键.
DOI:10.1002/adsc.202000615

专利信息

专利号:US-10801033-B2
优先权日:2016-04-05
标题 :Recombinant polynucleotide involved in lactone synthesis and process for synthesis of lactones thereof
发明人：GUPTA VIDYA SHRIKANT; DESHPANDE ASHISH BALWANT; OAK PRANJALI SUDHIR; GIRI ASHOK PRABHAKAR
权利人:COUNCIL SCIENT IND RES
摘要:The present invention provides the polynucleotide encoding enzyme involved in lactone synthesis and a process for synthesis of lactones using said polynucleotides. The invention also provides recombinant plasmid expression vector comprising said polynucleotide sequence. The recombinant protein encoded by said polynucleotides leads to synthesis of lactones having flavour peculiar to Alphonso mangoes.

专利号:US-9862745-B2
优先权日:2004-03-30
标题 :Synthesis of boronic ester and acid compounds
发明人：AMMOSCATO VINCE; BISHOP JOHN E; CHIU FANG-TING; GEISER ACHIM; GOMEZ JEAN-MARC; HETT ROBERT; KOELLNER CHRISTOPH; KULKARNI VITHALANAND R; LO YOUNG; MUNK STEPHEN; PICKERSGILL I FRASER
权利人:MILLENNIUM PHARM INC; MILLENNIUM PHARM INC
摘要:The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.

专利号:US-6780810-B2
优先权日:2002-03-13
标题:Multifunctional catalyst useful in the synthesis of chiral vicinal diols and process for the preparation thereof, and process for the preparation of chiral vicinal diols using said multifunctional catalysts
发明人：CHOUDARY BOYAPATI MANORANJAN; CHOWDARI NAIDU SREENIVASA; MADHI SATEESH; KANTAM MANNEPALLI LAKSHMI
权利人:COUNCIL SCIENT IND RES
摘要:The present invention relates to a multifunctional reusable catalyst and to a process for the preparation thereof on a single matrix of the support to perform multicomponent reaction in a single pot. The multifunctional catalysts of the invention are useful for the synthesis of chiral vicinal diols by tandem and/or simultaneous reactions involving Heck coupling, N-oxidation and AD reaction of olefins in presence of cinchona alkaloid compounds both as an native one and immobilized one in the said matrix support. This invention also relates to a process for preparing vicinal diols by asymmetric dihydroxylation of olefins in presence of cinchona alkaloid compounds employing reusable multifunctional catalysts as heterogeneous catalysts in place of soluble osmium catalysts.

专利号:WO-2025104679-A1
优先权日:2023-11-16
标题 :Processes for making intermediates for isoindolinone inhibitors of the mdm2-p53 interaction having anticancer activity
发明人：SHAKYA SAGAR; JOHNSON MATT; WONG NICHOLAS; BODHURI PRABHUDAS; DAVAR NIPUN
权利人:OTSUKA PHARMA CO LTD
摘要:The present disclosure relates to processes for preparing synthetic intermediates for the synthesis of isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity.

专利号:US-9045462-B2
优先权日:2012-08-17
标 题 :Synthesis of an antiviral compound
发明人：EVANS JARED WAYNE; FUJIMORI SHINJI; HUYNH GRACE M; LIU QI; TERESK MARTIN GERALD
权利人:GILEAD SCIENCES INC
摘要:The present disclosure provides processes for the preparation of a compound of Formula I: n nwhich is useful as an antiviral agent. The disclosure also provides compounds that are synthetic intermediates to compounds of formula.

专利号:EP-1346767-A1
优先权日:2002-03-15
标 题:Multifunctional catalyst useful in the synthesis of chiral vicinal diols and process for the preparation thereof
发明人：CHOUDARY BOYAPATI MANORANJAN; CHOWDARI NAIDU SREENIVASA; MADHI SATEESH; KANTAM MANNEPALLI LAKSHMI
权利人:COUNCIL SCIENT IND RES
摘要:The present invention relates to a multifunctional reusable catalyst and to a processnfor the preparation thereof on a single matrix of the support to perform multicomponentnreaction in a single pot. The multifunctional catalysts of the invention are useful for thensynthesis of chiral vicinal diols by tandem and / or simultaneous reactions involving Heckncoupling, N-oxidation and AD reaction of olefins in presence of cinchona alkaloidncompounds both as an native one and immobilized one in the said matrix support. Thisninvention also relates to a process for preparing vicinal diols by asymmetric dihydroxylationnof olefins in presence of cinchona alkaloid compounds employing reusable multifunctionalncatalysts as heterogeneous catalysts in place of soluble osmium catalysts.