CAS: 92611-10-4; Methyl N,N,N',N'-Tetrakis(1-Methylethyl)Phosphorodiamidite

上下游产品

methanol bis(diisopropylamino)chlorophosphine methyl dichlorophosphite diisopropylamineDiisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester Diisopropyl-phosphoramidous acid (2R,3S,5R)-5-(6-amino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester methyl ester Diisopropyl-phosphoramidous acid (2R,3S)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-pent-4-enyl-tetrahydro-furan-3-yl ester methyl ester 6-Benzoyl-9--6'-O--β-D-glucopyranosyl>adeninN6-Benzoyl-9-2',3'-dideoxy-4'-O-(diisopropylamino)(methoxy)phosphino-6'-O-(4,4'-dimethoxytriphenyl)methyl-β-D-glucopyranosyladenin

二异丙胺置于三乙胺,三氯化磷体系中,用 乙醚 作为反应溶剂,化学反应 12.0H,反应生成 N,N,N,N-四异丙基二氨基磷酸甲酯
参考文献:New Approach To The Synthesis Of Deoxyribonucleoside Phosphoramidite Derivatives
标题:New Approach To The Synthesis Of Deoxyribonucleoside Phosphoramidite Derivatives
摘要:在磷上具有各种保护基团的脱氧核糖核苷磷酰胺,以双(二异丙基氨基)氯膦作为新的磷酰化剂,无需分离双(二异丙基氨基)烷氧基膦,即可在一锅反应中快速制备,且收率非常好.
DOI:10.1246/cl.1986.1401

专利信息

专利号:US-8759508-B2
优先权日:2007-05-18
标 题 :Chromophoric silyl protecting groups and their use in the chemical synthesis of oligonucleotides
发明人：DELANEY MICHAEL OREN
权利人:DELANEY MICHAEL OREN; GE HEALTHCARE DHARMACON INC
摘要:The compounds are of class of chromophoric 1,2,3-triazolyl equipped silyl linking groups that are useful in the chemical synthesis of RNA. An example of a nucleoside comprising this group is

专利号:US-12291489-B2
优先权日:2016-07-01
标 题 :Synthesis of nanocomposites and their use in enhancing plant nutrition
发明人：BISWAS PRATIM; RALIYA RAMESH
权利人:BISWAS PRATIM; RALIYA RAMESH; WASHINGTON UNIVERSITY ST LOUIS
摘要:The present disclosure is related to the development of improved fertilizer for precision and sustainable agriculture. A method was developed wherein efficient NPK nanocomposite for plant nutrition was synthesized in a single step using aerosol science and technology concepts. Further a formulation was prepared by addition of ZnO, TiO 2 and other nanoparticles to the NPK nanocomposite. Also, an aerosol based foliar application technique was developed for the precise delivery of nanoparticles to the plants.

专利号:US-6175006-B1
优先权日:1988-12-21
标题:Automated system for polynucleotide synthesis and purification
发明人：ANDRUS WILLIAM A; MCCOLLUM CHRISTIE D; ZON GERALD
权利人:PERKIN ELMER CORP
摘要:A method and system for polynucleotide synthesis are provided which employ solid phase synthesis on a nonswellable porous polystyrene support by phosphoramidite or hydrogen phosphonate chemistries. The polystyrene support gives rise to fewer tritylated failure sequences caused by chain growth from extraneous support sites, and allows lower amounts of monomer reactants to be used to achieve equal or better coupling efficiencies as those achieveable with CPG. The method and system also employ nucleoside intermediates whose exocyclic amines are protected by base-labile groups which permit simultaneous cleavage and deprotection of the completed polynucleotide chain in the presence of the solid phase support. This latter feature allows practical automation of both the synthesis and purification of polynucleotides.

专利号:US-6518067-B1
优先权日:1997-02-17
标题:Automated chemical synthesis apparatus
发明人：FRANK RONALD; MATYSIAK STEFAN; SCHREUER OLAF; GAUSEPOHL HEINRICH; ROSENTHAL ANDRE
权利人:BIOTECHNOLOG FORSCHUNG GMBH; ABIMED ANALYSEN TECHNIK GMBH; IMB INST FUER MOLEKULARE BIO T
摘要:The disclosed synthesis system is based on the idea of designing a synthesis and treatment procedure, substrates and anchor groups which enable biomolecules to be simultaneously produced in an entirely automatic manner. By using a pipetting robot to dispense the reagents, the reaction column can be arranged in a format suitable for subsequent treatment. For a pipetting robot to carry out even water-sensitive or air-sensitive synthesis protocols, certain structural measures must be taken. The operation principle of the automated and the synthesis sequence are described below as an example of a possible solution. The automation can work with conventional substrates and reagents. Handling, however, is simplified by new, specially adapted substrates and anchor groups. A special, simultaneous purification and aliquot portioning process improves product quality and makes the device easier to use.

专利号:US-5047524-A
优先权日:1988-12-21
标题 :Automated system for polynucleotide synthesis and purification
发明人：ANDRUS WILLIAM A; MCCOLLUM CHRISTIE D; ZON GERALD
权利人:APPLIED BIOSYSTEMS
摘要:A method and system for polynucleotide synthesis and purification are provided which employ solid phase synthesis on a nonswellable porous polystyrene support by phosphoramidite or hydrogen phosphonate chemistries. The polystyrene support gives rise to fewer tritylated failure squences caused by chain growth from extraneous support sites. Consequently, currently used rapid purification techniques depending on trityl hydrophobicity give a more highly purified product. The method and system also employ nucleoside intermediates whose exocyclic amines are protected by base-labile groups which permit simultaneous cleavage and deprotection of the completed polynucleotide chain in the presence of the solid phase support. This latter feature allows practical automation of both the synthesis and purification of polynucleotides.

专利号:US-8026349-B2
优先权日:2004-08-20
标题 :Polynucleotide synthesis labeling chemistry
发明人：HARTSEL STEPHANIE A; KAISER ROBERT J; DELANEY MICHAEL O
权利人:DHARMACON INC
摘要:Methods and compositions for making nucleoside phosphoramidites and nucleic acids, including mono-, di-, and polynucleotides, comprising a linker covalently attached to a levulinyl moiety are provided. A levulinyl-protected linking moiety affords an orthogonal approach to modifying a polynucleotide during or after solid phase synthesis with a molecule of interest, for example, a conjugate or a dye.