专利号:US-2025162968-A1 优先权日:2022-02-02 标 题 :Method for Producing Ionizable Lipids or Intermediates for the Synthesis of Such Lipids 发明人:ATMURI N D PRASAD; ARNOLD DEAGLAN; SAADATI FARIBA; KUREK DANIEL; KULKARNI JAYESH; WITZIGMANN DOMINIK; CIUFOLINI MARCO A 权利人:NANOVATION THERAPEUTICS INC 摘要:The present disclosure provides a method for producing one or more intermediates for the synthesis of one or more ionizable lipids, the method comprising: (i) producing a beta-ketoacid by reacting a cyclic ester, a terminal hydroxyester or a derivative thereof, a dicarboxylic acid half ester, or an acid chloride derivative of the dicarboxylic acid half ester, in a condensation reaction, thereby producing the beta-ketoacid or a beta-ketoester that is hydrolyzed to produce the beta-ketoacid; and (ii) decarboxylating the beta-ketoacid, thereby producing the one or more intermediates, wherein the one or more intermediates have a structure that may be defined by Formula A. Further provided is a method for producing ionizable lipid from the intermediate comprising adding an ionizable head group moiety to (a) a ketone group of one or more intermediates having the structure that may be defined by Formula A; or (b) a corresponding alcohol of the intermediate.
专利号:US-11512401-B2 优先权日:2019-01-14 标题 :Process for short chain alkane synthesis while maintaining faradaic efficiency 发明人:O'MALLEY JAMES; MONTGOMERY DONALD 权利人:GRIDTHINK INC 摘要:There is disclosed a process for synthesis of a C2-8 alkane comprising: (a) providing an electrolyte formulation comprising from about 3N to about 6N C2-C5 carboxylic acid and from about 2 M to about 4 M alkali C2-C5 carboxylate, wherein the C2-C5 carboxylate and carboxylic acid have the same carbon alkyl length into a pressure vessel having an electrode cell or stack; (b) adding electrical current to the electrode cell or stack; (c) pressurizing the pressure vessel; and (d) recovering a gas stream from the pressure vessel comprising a C2-8 alkane, CO2 and H2. Preferably, the carboxylic acid is acetic acid and the alkane is ethane.
专利号:US-8884051-B2 优先权日:2010-10-20 标题:Synthesis of methylene malonates using rapid recovery in the presence of a heat transfer agent 发明人:MALOFSKY BERNARD M; MALOFSKY ADAM G; DEY TANMOY; SULLIVAN JEFFREY M; CHEN YANGBIN; WOJCIAK STANLEY C; COCKREM MICHAEL C 权利人:MALOFSKY BERNARD M; MALOFSKY ADAM G; DEY TANMOY; SULLIVAN JEFFREY M; CHEN YANGBIN; WOJCIAK STANLEY C; COCKREM MICHAEL C; BIOFORMIX INC 摘要:The present invention provides a method of making a methylene malonate monomer that includes the steps of reacting a malonic acid ester with a source of formaldehyde optionally in the presence of an acidic or basic catalyst and optionally in the presence of an acidic or non-acidic solvent to form reaction complex. The reaction is optionally performed in the presence of or contacted with an energy transfer means such as a heat transfer agent, a heat transfer surface, a source of radiation or a laser such that reaction complex is substantially vaporized to produce a vapor phase comprising methylene malonate monomer which may be isolated. The present invention further provides methylene malonate monomers prepared by the method of the invention, as well as compositions and products formed from the methylene malonate monomers, including monomer-based products (e.g., inks, adhesives, coatings, sealants or reactive molding) and polymer-based products (e.g., fibers, films, sheets, medical polymers, composite polymers and surfactants).
专利号:US-4215044-A 优先权日:1979-04-23 标题:Synthesis of α-fluorocarbonyl compounds 发明人:MIDDLETON WILLIAM J 权利人:DU PONT 摘要:Process for preparing an organic compound of the formula R 2 R 2 CFC(O)R 3 , which process comprises contacting and reacting in a reaction mixture which includes an inert solvent, at a temperature of -40° C. to -100° C., ROF and ##STR1## R is polyfluoroperhaloalkyl of 1-6 carbon atoms or FOCF 2 ; R 1 is hydrocarbyl of 1-6 carbon atoms; n each R 2 is selected from H, alkyl of 1-17 carbon atoms, cycloalkyl of 3-6 carbon atoms, aryl, heteroaryl and such alkyl, cycloalkyl, aryl and heteroaryl substituted by halogen or alkoxy of 1-6 carbon atoms; n R 3 is selected from H, alkyl and haloalkyl of 1-16 carbon atoms, cycloalkyl of 3-10 carbon atoms, aryl and haloaryl, OSi(R 1 ) 3 , OH, NH 2 , alkoxy of 1-6 carbon atoms, aryloxy, NHR 1 and NR 1 2 wherein R 1 is alkyl of 1-6 carbon atoms, N-arylamino and nitrogen or sulfur heterocyclic of 4-5 carbon atoms; n R 3 and one R 2 taken together is a diradical which with the Câ•?C group is carbocyclic, heterocyclic or haloheterocyclic, and recovering from the reaction mixture the compound of the formula R 2 R 2 CFC()R 3 .
专利号:US-10202488-B2 优先权日:2015-02-05 标 题:Isocyanate-free synthesis of carbonate-modified polymers 发明人:CRON CHRISTINA; BRENNER GABRIELE 权利人:EVONIK DEGUSSA GMBH 摘要:The present invention relates to an isocyanate-free and preferably solvent-free process for preparing polymers containing five-membered cyclic carbonate groups. In particular, the present invention is directed to a process for preparing polymers bearing cyclic carbonate groups by reacting carboxyl-bearing polymers selected from the group including polyesters based on di- or polyols and di- or polycarboxylic acids or derivatives thereof or poly(meth)acrylates, with hydroxyl-functionalized five-membered cyclic carbonates, without addition of isocyanates.
专利号:US-4629807-A 优先权日:1986-02-06 标 题 :Selective synthesis of aliphatic dicarboxylic acid esters using palladium-phosphine or palladium-arsine catalysts 发明人:KNIFTON JOHN F 权利人:TEXACO INC 摘要:A process for preparing aliphatic dicarboxylic acid esters from aliphatic, non-conjugated dienes via carbonylation in the presence of a homogeneous palladium-phosphine catalyst or a palladium-phosphine melt catalyst.
1: Ma HF, Liu B, Zhang GY, Shi RB, Ma CH, Yu MM. [GC-MS analysis of the fatty components of pollen Typhae before and after being carbonized]. Zhongguo Zhong Yao Za Zhi. 2006 Feb;31(3):200-2. Chinese. Russian.
合成参考文献
摘要:Kantchev, E. A. B.; Organ, M. G., Science of Synthesis, (2009) 48, 85. 摘要:Roy, K.-M., Science of Synthesis, (2010) 47, 1135. 摘要:Singh, F. V.; Wirth, T., Science of Synthesis: Catalytic Oxidation in Organic Synthesis, (2017) 1, 41.