专利号:US-2024158926-A1 优先权日:2022-11-03 标 题 :Electrochemical synthesis of hydroxyvaleric acid from levulinic acid 发明人:HOLEWINSKI ADAM; DE SOUZA LUCAS FRANCISCO WILLIAN 权利人:UNIV COLORADO REGENTS 摘要:Disclosed herein are methods of electrochemical synthesis of hydroxyvaleric acid from levulinic acid. For example, disclosed herein are methods comprising electrochemical synthesis of hydroxyvaleric acid from levulinic acid, wherein the method is conducted in an electrochemical cell wherein a working electrode is in electrochemical contact with an aqueous electrolyte and levulinic acid, wherein the method comprises applying a potential to electrochemically reduce the levulinic acid to form hydroxyvaleric acid. Also disclosed herein are methods of synthesizing gamma-valerolactone from hydroxyvaleric acid, the method comprising acid-catalyzed esterification. Also disclosed herein are methods of use of the products produced by any of the methods herein.
专利号:US-9085542-B1 优先权日:2014-06-12 标题:Method for synthesis of N-methyl piperazine diphenolamide and related composition 发明人:MCCLOSKEY PATRICK JOSEPH; LEE JULIA LAM; HOWSON PAUL EDWARD; ZHOU HONGYI 权利人:GEN ELECTRIC 摘要:A method for synthesis of N-methyl piperazine diphenolamide is presented. The method includes contacting diphenolic acid with N-methyl piperazine to form a reaction mixture; and heating the reaction mixture to form a reaction product including N-methyl piperazine diphenolamide. An associated composition is also presented.
专利号:US-11547655-B2 优先权日:2017-08-02 标 题:Use of an extract of the pericarp of Nephelium lappaceum for hydrating the skin and/or mucous membranes 发明人:BONNET ISABELLE; CADAU SÉBASTIEN; DANOUS LOUIS; DERCEVILLE CHARLOTTE; LEOTY-OKOMBI SABRINA 权利人:BASF BEAUTY CARE SOLUTIONS FRANCE S A S 摘要:A subject of the present invention is the cosmetic use of a pericarp extract of the plant Nephelium lappaceum for maintaining and/or increasing the hydration and/or the barrier effect of the skin and/or of the mucous membranes. The pericarp extract increases involucrin synthesis and the hyaluronic acid content and the synthesis of ATP and of the taurine transporter TAUT. Another subject of the invention relates to a cosmetic care process comprising the topical application of the pericarp extract of N. lappaceum. Finally, a subject of the invention relates to the pericarp extract for use, in particular dermatological use, thereof in the treatment and/or prevention of pathological conditions caused by a state of abnormal dryness of the skin and/or of the mucous membranes.
专利号:US-11612556-B2 优先权日:2014-12-16 标 题:Peptidic compounds, compositions comprising them and uses of said compounds, in particular cosmetic uses 发明人:PESCHARD OLIVIER; DOUCET ANNE; LEROUX RICHARD; MONDON PHILIPPE 权利人:SEDERMA SA 摘要:The peptidic compound comprises at least an aminoacid which is lysine, ornithine, diaminopropionic acid or diaminobutyric acid or a derivative of these aminoacids, on which a carboxylic acid is grafted via a peptidic bound on the nitrogen of the lateral chain, said carboxylic acid comprising a (poly)cycle or (poly)heterocycle. Preferably, the grafted carboxylic acid is an aminoacid or a derivative, in particular selected from, a proline, a hydroxyproline or pyroglutamic acid.The peptidic compound can stimulate the synthesis of the main molecules constituting the extracellular matrix of the skin, especially collagen 1 and 4 and elastin. It can be used for topical cosmetic treatment such as a global anti-aging treatment, or for specific activities, including anti-wrinkles, moisturizing, to improve the mechanical properties of the skin, firmness/tone/elasticity/flexibility, to increase density and volume of the skin, improve skin radiance, for a restructuring effect and/or to fight stretch marks.
专利号:WO-2018011741-A1 优先权日:2016-07-15 标 题:Synthesis of ketals and levulinates 发明人:STANISLAUS ALEXANDER; KORIPELLY GIRISH; GANJI SANTOSH; GANAPATHY BHOTLA VENKATA RAMANARAYANAN; NARAYANASWAMY RAVICHANDER; RAMAURTHY KRISHNA KUMAR 权利人:SABIC GLOBAL TECHNOLOGIES BV 摘要:Disclosed are methods for preparing a levulinic acid mixture in a reaction vessel that is, for example, suitable for use in synthesizing a glyceryl ketal of levulinic acid or an ester of levulinic acid comprising distilling a combination comprising levulinic acid, formic acid, sulphuric acid, and water with an organic solvent in order to separate water and formic acid from the combination, thereby forming the levulinic acid mixture. The levulinic acid mixtures that are prepared according to such methods may therefore be used to produce high yields of a glyceryl ketal of levulinic acid or an ester of levulinic acid that have a high level of purity relative to prior art compounds.
专利号:US-2004110228-A1 优先权日:2002-04-01 标 题:Combinatorial organic synthesis of unique biologically active compounds 发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M 摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.