CAS: 153439-40-8; 2-(4-(1-Hydroxy-4-(4-(Hydroxydiphenylmethyl)Piperidin-1-yl)Butyl)Phenyl)-2-Methylpropanoic Acid Hydrochloride

非索芬那定置于盐酸体系中,用 甲醇,水 用作溶剂,化学反应生成盐酸非索非那定
参考文献: Polymorphic Form Xvi Of Fexofenadine Hydrochloride[fr] Forme Polymorphe Xvi De L'Hydrochlorure De Fexofenadine
标题: Polymorphic Form Xvi Of Fexofenadine Hydrochloride[fr] Forme Polymorphe Xvi De L'Hydrochlorure De Fexofenadine
摘要:提供的是一种晶体(多形)形式的盐酸费托芬啶,命名为盐酸费托芬啶xvi型.

专利信息

专利号:US-2025206743-A1
优先权日:2022-03-25
标 题:Tyk2 inhibitor synthesis and intermediates thereof
发明人：MASSE CRAIG E; PHADKE AVINASH S; LAWSON JON P; LEVY STUART; YANG XIAOWEI; WU GUISHENG; FAN SHUFENG
权利人:TAKEDA PHARMACEUTICALS CO
摘要:Described herein are methods of synthesis of a tyrosine-protein kinase 2 (TYK2) inhibitor and to intermediate compounds of the synthesis and methods of making the intermediates. Also provided are pharmaceutically acceptable compositions including compounds prepared by the synthetic method and methods of treating disorders using the same.

专利号:US-11891683-B2
优先权日:2017-11-28
标题 :Thermal shock synthesis of multielement nanoparticles
发明人：YAO YONGGANG; HU LIANGBING
权利人:UNIV MARYLAND
摘要:A formation of multielement nanoparticles is disclosed that includes at least three elements. Each of the at least three elements is uniformly distributed within the multielement nanoparticles forming nanoparticles having a homogeneous mixing structure. At least five elements may form a high-entropy nanoparticle structure. A method for manufacturing a formation of multielement nanoparticles includes providing a precursor material composed of the at least three component elements in multielement nanoparticles; heating the precursor material to a temperature and a time; and quenching the precursor to a temperature at a cooling rate to result in a formation of multielement nanoparticles containing at least three elements and the heating and the quenching representing a multielement nanoparticle thermal shock formation process. A corresponding system for manufacturing the formation of multielement nanoparticles and a method of using the multielement nanoparticles are also disclosed.

专利号:US-6147217-A
优先权日:1997-02-04
标题:Synthesis of terfenadine and derivatives
发明人：SENANAYAKE CHRIS HUGH; FANG QUN KEVIN; WILKINSON SCOTT HAROLD
权利人:SEPRACOR INC
摘要:Processes for preparing compounds having the general formula: ##STR1## wherein R 1a is protected carboxy, carboxy, hydroxymethyl, protected hydroxymethyl, or methyl are disclosed. Processes of the invention begin with a starting material of the general formula IV ##STR2## wherein R 1 and R 2 are as defined in the specification.

专利号:WO-2024065031-A1
优先权日:2022-09-27
标题 :Method of transitory synthesis of nanoparticles
发明人：CHEN PAUL; GU FRANK
权利人:GOVERNING COUNCIL UNIV TORONTO
摘要:There is provided a method for growing nanoparticle's seeds or nanoparticles. The method includes mixing a first solution with a second solution. The first solution includes at least one of the nanoparticle's seeds or the nanoparticles. The second solution includes a transitory ligand, the transitory ligand being transiently adsorbed to an inorganic portion of said at least one of the nanoparticle's seeds and the nanoparticles when the first solution is mixed with the second solution. The method also includes substituting the transitory ligand with a capping agent.

专利号:US-2007299102-A1
优先权日:2004-04-08
标题:Diphenyl Ox-Indol-2-One Compounds and Their Use in the Treatment of Cancer
发明人：FELDING JAKOB; PEDERSEN HANS C; KROG-JENSEN CHRISTIAN; PRAESTEGAARD MORTEN; BUTCHER STEVEN P; LINDE VIGGO; COULTER THOMAS S; MONTALBETTI CHRISTIAN; UDDIN MOHAMMED; REIGNIER SERGE
权利人:TOPOTARGET AS
摘要:The present invention relates to substituted 3,3-diphenyl-1,3-dihydro-indol-2-one compounds, and the use of such compounds for the preparation of a medicament for the treatment of cancer in a mammal. It is postulated that treatment of cancers is achieved in which inhibition of protein synthesis and/or inhibition of activation of the mTOR pathway is an effective method for reducing cell growth. Examples of such cancers are breast cancer, renal cancer, multiple myeloma, leukemia, glia blastoma, rhabdomyosarcoma, prostate, soft tissue sarcoma, colorectal sarcoma, gastric carcinoma, head and neck squamous cell carcinoma, uterine, cervical, melanoma, lymphoma, and pancreatic cancer. A particular subclass of compounds are represented by the formula (II) n n nwherein at least one of X 1 and X 2 is a heteroatom substituent, e.g. 6-chloro-3,3-bis-(4-hydroxy-phenyl)-7-methyl-1,3-dihydro-indol-2-one.

专利号:US-2024218493-A1
优先权日:2017-11-28
标 题 :Thermal shock synthesis of multielement nanoparticles