CAS: 17249-82-0; 2-Chloro-5-Methylthiophene

上下游产品

2-Methylthiophene 5-Chloro-2-thiophenecarboxaldehyde 5-Chloro-2-thiophenecarboxaldehyde glycolsaeureethylester3-(5-Chlor-2-methyl)thienylglycolsaeureethylester 1,5‐bis(5‐chloro‐2‐methylthiophen‐3‐yl)pentane‐1,5‐dione 3-bromo-5-chloro-2-methylthiophene

2-甲基噻吩置于三甲基氯硅烷,[双(三氟乙酰氧基)碘]苯体系中,用 二氯甲烷 用作溶剂,化学反应 18.0H,以86%的收率获得2-氯-5-甲基噻吩
参考文献:原位生成超价碘试剂用于芳烃的亲电氯化反应
标题:原位生成超价碘试剂用于芳烃的亲电氯化反应
摘要:据报道,使用pifa和简单的氯源进行芳烃的亲电氯化的高效无金属方法.当分别使用pifa-kcl和pifa-tmscl的组合时,有人建议原位形成不同的基于i(III)的物质,例如phi(ococf 3)cl和phicl 2作为氯化剂.
Doi:10.1002/ejoc.201900237

专利信息

专利号:WO-2013046211-A1
优先权日:2011-09-27
标 题 :Processes for the preparation of 5-chloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4-morpholinyl) phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophene-carboxamide and intermediates thereof
发明人：MOHAN RAO DODDA; KRISHNA REDDY PINGILI; VENKAT REDDY BUTHUKURI
权利人:SYMED LABS LTD; MOHAN RAO DODDA; KRISHNA REDDY PINGILI; VENKAT REDDY BUTHUKURI
摘要:TThe present invention provides processes for the preparation of 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophene-carboxamide (I) and intermediates thereof. Also provides novel intermediates and their use in the synthesis of oxazolidine derivatives.

专利号:US-9243004-B2
优先权日:2011-07-22
标题 :Synthesis of boronic esters and boronic acids using grignard reagents
发明人：CLARY JACOB W; SINGARAM BAKTHAN
权利人:CLARY JACOB W; SINGARAM BAKTHAN; UNIV CALIFORNIA
摘要:Boronic esters and boronic acids are synthesized at ambient temperature in an ethereal solvent by the reaction of Grignard reagents with a boron-containing substrate. The boron-containing substrate may be a boronic ester such as pinacolborane, neopentylglycolborane, or a dialkylaminoborane compound such as diisopropylaminoborane. The Grignard reagents may be pre-formed or generated from an alkyl, alkenyl, aryl, arylalkyl, heteroaryl, vinyl, or allyl halide compound and Mg 0 . When the boron-containing substrate is a boronic ester, the reactions generally proceed at room temperature without added base in about 1 to 3 hours to form a boronic ester compound. When the boron-containing substrate is a dialkylaminoborane compound, the reactions generally proceed to completion at 0° C. in about 1 hour to form a boronic acid compound.

专利号:US-8598166-B2
优先权日:2008-03-21
标 题:Polysubstituted derivatives of 6-heteroarylimidazo[1,2-a]pyridines, and preparation and therapeutic use thereof
发明人：DE PERETTI DANIELLE; EVANNO YANNICK; MACHNIK DAVID; RAKOTOARISOA NATHALIE
权利人:DE PERETTI DANIELLE; EVANNO YANNICK; MACHNIK DAVID; RAKOTOARISOA NATHALIE; SANOFI SA
摘要:Compounds of formula (I): n nwherein R 1 , R 2 , R 3 , R 4 , Het and X are as defined in the disclosure, or an acid addition salt thereof, and the therapeutic use and process of synthesis thereof.

专利号:US-8338451-B2
优先权日:2008-03-21
标 题 :Polysubstituted derivatives of 2-heteroaryl-6-phenylimidazo[1,2-a]pyridines, and preparation and therapeutic use thereof
发明人：DE PERETTI DANIELLE; EVANNO YANNICK; LARDENOIS PATRICK; MACHNIK DAVID; RAKOTOARISOA NATHALIE; ALMARIO GARCIA ANTONIO
权利人:DE PERETTI DANIELLE; EVANNO YANNICK; LARDENOIS PATRICK; MACHNIK DAVID; RAKOTOARISOA NATHALIE; ALMARIO GARCIA ANTONIO; SANOFI SA
摘要:Compounds of formula (I): n nwherein R, R 1 , R 2 , R 3 , R 4 and X are as defined in the disclosure, or an acid addition salt thereof, and the therapeutic use and process of synthesis thereof.

专利号:US-4369322-A
优先权日:1978-12-15
标 题 :Process for the production of substituted acetonitriles
发明人：SCHALKE PETER; KLEEMANN AXEL
权利人:DEGUSSA
摘要:The known synthesis for the production of aromatic substituted acetonitriles by reaction of aromatic substances with cyanogen chloride in the gas phase is improved by feeding the starting materials in gaseous form and separated from each other into the reactor. The process can be used to synthesize in general aromatic and especially hetero-aromatic substituted acetonitrile.

专利号:US-8536205-B2
优先权日:2005-05-25
标 题 :Photochromic and electrochromic compounds and synthesis and use thereof
发明人：BRANDA NEIL R; WUESTENBERG BETTINA; LEMIEUX VINCENT; ADAMS MICHAEL; GAUTHIER SIMON
权利人:BRANDA NEIL R; WUESTENBERG BETTINA; LEMIEUX VINCENT; ADAMS MICHAEL; GAUTHIER SIMON; SWITCH MATERIALS INC
摘要:Photochromic and electrochromic hexadiene compounds that are reversibly convertible between ring-open and ring-closed isomeric forms. The conversion between the different isomeric forms may be induced by light or electricity. The compounds may include a charge transfer moiety including electron donor and acceptor groups. The electron donor and acceptor are linearly conjugated in the ring-open form to enable electron transfer but are electrically insulated in the ring-closed form. Photoresponsive compounds may be synthesized by any of several methods disclosed, e.g., by reacting diene precursors with dienophiles in a condensation reaction. The compounds may be utilized in reactivity-gated photochromic or electrochromic applications. Compounds may be used in a method to selectively release a releasable agent, such as a small molecule.