CAS: 1822-51-1; 4-(Chloromethyl)Pyridine Hydrochloride

相似化合物

39178-35-3 847610-87-1 73870-24-3

上下游产品

CAS号586-95-8 4-吡啶甲醇 | CAS号63608-12-8 4-phenoxymethyl... | CAS号62302-28-7 4-吡啶甲醇盐酸盐 | CAS号121-44-8 三乙胺 | CAS号1003-67-4 4-甲基吡啶-N-氧化物 | CAS号105431-72-9 利诺吡啶 (DUP996) | CAS号50392-78-4 1-(4-吡啶基)乙胺 | CAS号141101-93-1 5-phenylmethoxy... | CAS号142979-87-1 5,5-bis(pyridin... | CAS号23389-76-6 1-pyridin-4-ylp... | CAS号6971-44-4 N-甲基-N-(4-吡啶甲基)胺 | CAS号1020-71-9 双(4-吡啶甲基)二硫化物 | CAS号1539-39-5 加匹可明 | CAS号64460-41-9 4-吡啶甲胺盐酸盐 | CAS号152814-89-6 1-(3-Nitropheny...

4-甲基吡啶置于aluminum (III) Chloride,Sodium Tetrahydroborate,Potassium Permanganate,氯化亚砜,硫酸体系中,用 四氢呋喃,甲醇,水,甲苯 用作溶剂,化学反应 0.58H,反应生成4-氯甲基吡啶盐酸盐
参考文献:一种4-氯甲基吡啶盐酸盐的合成方法
标题:一种4-氯甲基吡啶盐酸盐的合成方法
摘要:本发明属于有机合成领域,具体涉及一种4‑氯甲基吡啶盐酸盐的合成方法,该方法包括以下步骤:(1)以4‑甲基吡啶为原料,以水作溶剂,用高锰酸钾将其氧化为4‑吡啶甲酸,其中,4‑甲基吡啶与高锰酸钾的摩尔比为1:2.1‑2.3,氧化温度为75‑80°C,加热35Min,反应完全将反应液调节为酸性,再冷却过滤得4‑吡啶甲酸;(2)4‑吡啶甲酸与甲醇在酸性条件下生成4‑吡啶甲酸甲酯,其中4‑吡啶甲酸与甲醇的摩尔比为1:1.3;(3)还原4‑吡啶甲酸甲酯为4‑吡啶甲醇;(4)4‑吡啶甲醇与氯化亚砜反应得到目的产物4‑氯甲基吡啶盐酸盐,4‑吡啶甲醇与氯化亚砜的摩尔比为1:1.1‑1.3.

专利信息

专利号:US-6166031-A
优先权日:1987-10-19
标 题:Substituted tetralins, chromans and related compounds in the treatment of asthma
发明人：EGGLER JAMES F; MARFAT ANTHONY; MELVIN JR LAWRENCE S
权利人:PFIZER
摘要:Substituted tetralins, chromans and related compounds which, by inhibiting 5-lipoxygenase enzyme and/or blocking leukotriene receptors, are useful in the prevention or treatment of asthma, arthritis, psoriasis, ulcers, myocardial infarction and related disease states in mammals; pharmaceutical compositions comprising said compounds; a method of treatment with said compounds; and intermediates useful in the synthesis of said compounds.

专利号:US-4500535-A
优先权日:1979-10-15
标 题:Method of regulating the immune response with pyridine derivatives
发明人：LOMBARDINO JOSEPH G; HARBERT CHARLES A
权利人:PFIZER
摘要:A series of 4-(2-carboxymethylthiomethyl)pyridines and related compounds, and their pharmaceutically acceptable salts, are disclosed as having immunoregulatory activity. Preferred compounds include 4-(2-carboxymethylthiomethyl)pyridine [alternatively named 2-(4-picolylthio)acetic acid] and (C 1 -C 4 )alkyl esters thereof, and 4-(1-formylmethylthiomethyl)-pyridine [alternatively named 2-(4-picolylthio)acetaldehyde] and bis(C 1 -C 4 )alkyl or cyclic acetals thereof. These acids, esters, aldehydes and acetals also have utility as intermediates in the synthesis of the corresponding 4-(2-hydroxyethylthiomethyl)pyridines.

专利号:US-4963678-A
优先权日:1989-10-27
标题 :Process for large-scale production of BMY 21502
发明人：MADDING GARY D; MINIELLI JOSEPH L; MATTSON RONALD J
权利人:BRISTOL MYERS SQUIBB CO
摘要:An improved process, suitable for adaption to large-scale manufacture for synthesis of the cerebral function enhancing agent BMY 21502.

专利号:US-9562037-B2
优先权日:2014-02-26
标题:Synthesis and use of amine-containing flavonoids as potent anti-leishmanial agents
发明人：CHOW LARRY MING-CHEUNG; CHAN WILLIAM TAK HANG; CHAN KIN-FAI; WONG IRIS LAI KING; KAN WING-YIU
权利人:UNIV HONG KONG POLYTECHNIC
摘要:The present invention relates to novel series of amine-containing flavonoids and compositions containing the compounds, as well as the synthesis and the use of the same. The invention also relates to methods of treatment and prevention of diseases, in particular, parasitic infections including Leishmaniasis, comprising administration of the compounds.

专利号:US-10111854-B2
优先权日:2014-02-26
标题 :Synthesis and use of amine-containing flavonoids as potent anti-leishmanial agents
发明人：CHOW LARRY MING-CHEUNG; Chan Tak Hang William; CHAN KIN-FAI; WONG IRIS LAI KING; KAN WING-YIU
权利人:UNIV HONG KONG POLYTECHNIC
摘要:The present invention relates to novel series of amine-containing flavonoids and compositions containing the compounds, as well as the synthesis and the use of the same. The invention also relates to methods of treatment and prevention of diseases, in particular, parasitic infections including Leishmaniasis, comprising administration of the compounds.

专利号:US-6492529-B1
优先权日:2000-01-18
标题 :Bis pyrazole-1H-pyrazole intermediates and their synthesis
发明人：KAPADIA SURESH R; SONG JINHUA J; YEE NATHAN K
权利人:BOEHRINGER INGELHEIM PHARMA
摘要:Disclosed are aromatic heterocyclic compounds of the formula (I) wherein Ar 1 , Ar 2 , L, Q and X are described herein, and intermediate compounds useful for making such compounds. The compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. n Also disclosed are processes of making compounds of the formula (I), their intermediates and processes of making such intermediates, including bis pyrazole-1H-pyrazole intermediates of the formula: n wherein Alk, R x and R z are described herein.