CAS: 202925-08-4; 1-Chloro-3-Fluoro-5-Methoxybenzene

上下游产品

CAS号929626-16-4 2-(3-氯-5-甲氧基苯基)... | CAS号2845-89-8 3-氯苯甲醚 | CAS号202982-70-5 3-氯-5-氟苯酚 | CAS号2339-58-4 3-氟-5-甲氧基苯胺

3-氯-5-甲氧基苯硼酸频那醇酯置于1-Fluoro-2,4,6-Trimethylpyridinium Hexafluorophosphate,(Tbucn)2Cu*otf,Silver Fluoride体系中,用 四氢呋喃 用作溶剂,化学反应 18.0H,反应生成3-氯-5-氟苯甲醚
参考文献:Copper-Mediated Fluorination Of Arylboronate Esters. Identification Of A Copper(III) Fluoride Complex
标题:Copper-Mediated Fluorination Of Arylboronate Esters. Identification Of A Copper(III) Fluoride Complex
摘要:A Method For The Direct Conversion Of Arylboronate Esters To Aryl Fluorides Under Mild Conditions With Readily Available Reagents Is Reported. Tandem Reactions Have Also Been Developed For The Fluorination Of Arenes And Aryl Bromides Through Arylboronate Ester Intermediates. Mechanistic Studies Suggest That This Fluorination Reaction occurs Through Facile Oxidation Of Cu(I) To Cu(III),Followed By Rate-Limiting Transmetalation Of A Bound Arylboronate To Cu(III). Fast C-F Reductive Elimination Is Proposed To occur From An Aryl-Copper(III)-Fluoride Complex. Cu(III) Intermediates Have Been Generated Independently And Identified By NMR Spectroscopy And Esi-Ms.
Doi:10.1021/ja310909Q

专利信息

专利号:US-2019002448-A1
优先权日:2015-12-31
标 题 :Substituted benzofuranyl and benzoxazolyl compounds and uses thereof
发明人：BALOGLU ERKAN
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to substituted benzofuranyl and substituted benzoxazolyl compounds, and more particularly to a compound represented by Structural Formula (I) or (II), or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of Structural Formula A, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders.