专利号:WO-2007139998-A2 优先权日:2006-05-25 标题:Synthesis of a compound which is a suitable intermediate in the synthesis of oxindoledioxane derivatives
专利号:US-8067460-B2 优先权日:2004-10-04 标 题 :5-phenoxyalkoxypsoralens and methods for selective inhibition of the voltage gated Kv1.3 potassium channel 发明人:WULFF HEIKE; SANKARANARAYANAN ANANTHAKRISHNAN; HAENSEL WOLFRAM; SCHMITZ ALEXANDER; SCHMIDT-LASSEN KRISTINA 权利人:WULFF HEIKE; SANKARANARAYANAN ANANTHAKRISHNAN; HAENSEL WOLFRAM; SCHMITZ ALEXANDER; SCHMIDT-LASSEN KRISTINA; UNIV CALIFONIA 摘要:Compositions of matter comprising 5-phenoxyalkoxypsoralen compounds and their method of synthesis and use. The compounds are useable to treat diseases or disorders in human or animal subjects, including autoimmune diseases. The compounds inhibit potassium channels, including the Kv1.3 channel and at least some of the therapeutic effects of such compounds may be due at least in part to potassium channel inhibition. In some embodiments, the compounds are more selective for certain potassium channels (e.g., Kv1.3 channels) than other potassium channels (e.g., Kv1.5 channels).
专利号:CA-2640585-A1 优先权日:2003-02-05 标题 :Synthesis of 2-butyl-3-(2'-(1-trityl-1h-tetrazol-5-yl)biphenyl-4-yl)-1,3-diazaspirol{4,4}-non-ene-4-one
专利号:WO-2004096171-A1 优先权日:2003-04-29 标题 :Skin whitening cosmetic composition comprising the extract of machilus thunbergii and the compounds isolated therefrom 发明人:SON JONG-KEUN; LEE SEUNG-HO; CHANG HYEUN-WOOK 权利人:YEUNGNAM EDUCATIONAL FOUND; SON JONG-KEUN; LEE SEUNG-HO; CHANG HYEUN-WOOK 摘要:The present invention is related to a cosmetic composition comprising the extract of Machilus thunbergii and lignan compounds isolated therefrom having potent inhibitory effect on melanin synthesis. Inventive composition shows the excellent inhibitory activity on cultured B-16 melanoma cell therefore, it can be useful in skin whitening cosmetic composition as an cream, skin, lotion, pack and the like.
专利号:US-2008242662-A1 优先权日:2005-05-31 标题 :Organic Compounds 发明人:NIHONYANAGI ATSUKO; TOYAO ATSUSHI; IWAKI YUKI; MASUYA KEIICHI 权利人:NIHONYANAGI ATSUKO; TOYAO ATSUSHI; IWAKI YUKI; MASUYA KEIICHI 摘要:The invention relates to substituted 3,4- or higher substituted piperazine compounds, the use thereof for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; pharmaceutical formulations or products comprising said compounds, and/or a method of treatment comprising administering said compounds, a method for the manufacture of said compounds as well as novel intermediates, starting materials and/or partial steps for their synthesis. The compounds are especially of the formula I, n n n n n n n n n n wherein R1, R2, R11, C, E and D are as defined in the specification.
专利号:US-7579356-B2 优先权日:2005-05-04 标 题:Thia-tetraazaacenaphthylene kinase inhibitors 发明人:BATTISTA KATHLEEN A; BIGNAN GILLES C; CONNOLLY PETER J; HAYDEN STUART; JOHNSON SIGMOND G; LIN RONGHUI; PANDEY NIRANJAN B; POWELL MARK T 权利人:JANSSEN PHARMACEUTICA NV 摘要:The present invention is directed to novel thia-tetraazaacenaphthylene compounds of Formula (I): n nand pharmaceutically acceptable forms thereof and their synthesis and use as inhibitors of ATP-protein kinase interactions.