CAS: 4651-82-5; 2-Aminothiophene-3-Carbonitrile

上下游产品

1,4-dithiane-2,5-diol malononitrile acetaldehyde thieno[2,3-d]pyrimidin-4(3H)one thieno[2,3-d]pyrimidin-4-amine (pyrrolyl-1)-2 thiophene carbonitrile-3 pyrimidin-2,4(1H,3H)-dithionethieno2,3-dpyrimidin-2,4(1H,3H)-dithione

1,4-二硫-2,5-二醇,丙二腈置于三乙胺体系中,用 甲醇 作为反应溶剂,化学反应 4.0H,反应生成 2-氨基噻吩-3-甲腈
参考文献:Design,Synthesis And Antifungal Activity Of New Schiff Bases Bearing 2-Aminothiophene Derivatives Obtained By Molecular Simplification
标题:Design,Synthesis And Antifungal Activity Of New Schiff Bases Bearing 2-Aminothiophene Derivatives Obtained By Molecular Simplification
摘要:设计并合成了17个带有2-氨基噻吩衍生物的席夫碱,采用分子简化方法.得到的化合物(4A-4Q)被评估其对皮肤真菌的体外抗真菌活性.预测它们的药物样性和药代动力学性质,建立它们的构效关系(sar),并对最活性的化合物进行细胞毒性评价.使用环保的微波辅助合成程序,合成产率非常好(35-85%).化合物4A-4Q具有非常好的药物样性和药代动力学特性,在测试的任何细胞系中,最高浓度为100μm时均没有细胞毒性.具有最佳抗真菌活性的化合物是4E,4F,4G,4K,4L,4M,4O和4P,其最小抑制浓度(mic)值在16-64μg Ml-1之间,因此在某些情况下比参考药物(氟康唑)更好.构效关系测试表明,卤素和硝基取代基的存在会增加抗真菌活性.综合结果表明,2-氨基噻吩衍生物是有希望作为抗真菌药物开发的领先化合物.
DOI:10.21577/0103-5053.20210004

专利信息

专利号:US-8034895-B2
优先权日:2004-02-04
标题 :Conjugated thiophenes having conducting properties and synthesis of same
发明人：SKENE WILLIAM G
权利人:UNIV MONTREAL
摘要:The present invention relates to conjugated oligomers and polymers comprising aromatic thiophene cores. The conjugated materials are obtained by simple and efficient condensation of an aryl diamine and an aryl dialdehyde or a bifunctional aryl moiety comprising both an aldehyde and an amine. Condensation of the complementary moieties at temperatures ranging from ambient to refluxing temperatures in various solvents resulted in conjugated oligomers and polymers that can subsequently be cast into thin films. Oligomerization and polymerization can be done under mild conditions with removal of the resulting water bi-product responsible for shifting the equilibrium in favor of the conjugated products. The resulting conjugated compounds can be made conducting with dopants affording electrically conducting materials of either p-type or n-type conductors depending on the dopant selected.

专利号:US-2007287842-A1
优先权日:2004-02-04
标题 :Conjugated Thiophenes Having Conducting Properties and Synthesis of Same

专利号:US-4257942-A
优先权日:1977-10-06
标题:New water-insoluble azo dyes
发明人：DEFEO FRANCESCO; CIPOLLI ROBERTO
权利人:ACNA
摘要:The present invention relates to the synthesis of new dyes having the following general formula: wherein: D is the residue of a diazotizable component of the carbocyclic or heterocyclic series X is an ethylene group, optionally substituted by halogen-methyl, alkyl C1-C4, aryl, aralkyl or CH2OCO(HN)nR (wherein R and n have the meanings hereinafter defined); R is alkyl C1-C8 optionally substituted by halogen, CN,COOH; aryl optionally substituted by one or more atoms of halogen, alkyl C1-C4, alkoxyl C1-C4; alkoxyl C1-C4; alkoxyl C1-C8; Aryloxy; aralkoxy; cycloalkoxy; aralkyl; naphthyl optionally substituted by halogen; alkenyl C2-C8, optionally substituted by halogen, CN, COOH; R1 and R2, either like or unlike each other, may be alkyl C1-C4 optionally substituted by halogen or CN groups; aralkyl; R3 is H; halogen, alkyl C1-C4; alkoxyl C1-C4, optionally substituted. n is 0 or 1.

专利号:US-2012004386-A1
优先权日:2004-02-04
标题 :Conjugated thiophenes having conducting properties and synthesis of same

专利号:WO-2005073265-A1
优先权日:2004-02-04
标题 :Conjugated thiophenes having conducting properties and synthesis of same

专利号:US-9533996-B2
优先权日:2012-06-18
标 题 :Therapeutic thiophene-, furan-, and pyridine-fused azolopyrimidin-5-(6h)-ones
发明人：BRANSTETTER BRYAN; BREITENBUCHER JAMES; DYCK BRIAN; GOMEZ LAURENT; HUDSON ANDREW RICHARD; MARRONE TAMI JO; PETERS MARCO; VICKERS TROY; WEINHOUSE MICHAEL
权利人:DART NEUROSCIENCE (CAYMAN) LTD
摘要:Described herein are compounds of Formula I and Formula II, methods of their synthesis, compositions comprising the compounds, and use of the compounds and compositions in treating numerous diseases and disorders, including cognitive deficits associated with CNS diseases and disorders.