CAS: 537-65-5; N1-(4-Aminophenyl)Benzene-1,4-Diamine

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CAS号1821-27-8 双(4-硝基苯基)胺 | CAS号106-50-3 对苯二胺 | CAS号350-46-9 对氟硝基苯 | CAS号6149-34-4 4-氨基-4-硝基二苯胺 | CAS号100-01-6 对硝基苯胺 | CAS号106038-75-9 N,N-bis(4-nitro... | CAS号142-04-1 苯胺盐酸盐 | CAS号563-70-2 溴代硝基甲烷 | CAS号488-48-2 四溴对苯醌 | CAS号18087-26-8 1,4-Benzenediam... | CAS号61236-15-5 N-[4-(4-acetami...

硝基苯置于盐酸,Tin,Sodium Hydroxide体系中,用 水,二甲基亚砜 作为反应溶剂,化学反应 30.0H,反应生成 4,4'-二氨基二苯胺
参考文献:轻松合成寡聚苯胺作为永久染发剂:化学修饰如何赋予颜色并避免毒性†
标题:轻松合成寡聚苯胺作为永久染发剂:化学修饰如何赋予颜色并避免毒性†
摘要:许多用于持久染发的染料都含有芳香胺,这些胺会发生氧化聚合反应,从而导致过敏性接触性皮炎,并可能产生严重的毒性作用.在这些胺中,对苯二胺(ppd)是苯胺的小分子形式,尽管它是人类已知的过敏原,但通常用于美容产品中.因此,在这项研究中,我们通过合成寡聚ppd和在ppd上引入庞大的侧链来设计和合成更安全的ppd类似物,以克服ppd染料的毒性.我们假设(a)通过在游离胺上添加ppd单体单元来增加ppd的分子大小,以及(b)在邻位进行战略性官能化具有强供电子大基团的ppd的位置能够保持染发性能,并增加与皮肤蛋白结合的抵抗力,因此减少了皮肤致敏的机会.合成了13种低聚物,目的是生产更安全的染发剂,同时最大程度地减少对人体的最终毒性.尤其是,带有大侧链的低聚物,Ppd 6(13),Ppd 7(14)和ppd 8(15)表现出弱至中度(27.1%,24.1%和34.0%)的敏化潜能.该结果证实了具有大而强
DOI:10.1039/c9Nj03362A

专利信息

专利号:US-6086852-A
优先权日:1997-11-13
标 题:In vivo stain composition, process of manufacture, and methods of use to identify dysplastic tissue
发明人：BURKETT DOUGLAS D
权利人:ZILA INC
摘要:PCT No. PCT/US97/20981 Sec. 371 Date May 20, 1999 Sec. 102(e) Date May 20, 1999 PCT Filed Nov. 13, 1997 PCT Pub. No. WO99/25388 PCT Pub. Date May 27, 1999N-demethylated and N,N-demethylated derivatives of toluidine blue O and compositions which include these derivatives and the conformational isomers of toluidine blue O. Improved methods for the detection of dysplastic oral tissue using such compositions. Processes for synthesis of toluidine blue O products, in which a complexing agent is introduced prior to the last stage of oxidation of a three-step synthesis from N,N-dimethyl- rho -phenylenediamine. An HPLC method for characterizing toluidine blue O products in which the mobile phase is an aqueous solution of an organic acid.

专利号:US-6235871-B1
优先权日:1997-12-03
标题:Synthesis of oligoarylamines, and uses and reagents related thereto
发明人：SINGER ROBERT A; SADIGHI JOSEPH P; BUCHWALD STEPHEN L; MACKEWITZ THOMAS
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:The transition metal-catalyzed amination of aryl halides, in conjunction with an orthogonal protective group scheme, forms the basis of two routes to oligoaniline precursors. The oligoaniline precursors are soluble in a variety of common organic solvents, and are easily converted to the deprotected oligoanilines. The method allows the preparation of oligoanilines of even or odd chain lengths, and the incorporation of a variety of functional groups into the oligomers. Polyanilines of low polydispersity can also be prepared by this method.

专利号:US-7476765-B2
优先权日:2002-12-17
标 题:Chemical synthesis of chiral conducting polymers
发明人：WANG HSING-LIN; LI WENGUANG
权利人:LOS ALAMOS NAT SECURITY LLC
摘要:An process of forming a chiral conducting polymer, e.g., polyaniline, is provided including reacting a monomer, e.g., an aniline monomer, in the presence of a chiral dopant acid to produce a first reaction mixture by addition of a solution including a first portion of an oxidizing agent, the first portion of oxidizing agent characterized as insufficient to allow complete reaction of the monomer, and further reacting the first reaction mixture in the presence of the chiral dopant acid by addition of a solution including a second portion of the oxidizing agent, the second portion of oxidizing agent characterized as insufficient to allow complete reaction of the monomer, and repeating the reaction by addition of further portions of the oxidizing agent until the monomer reaction is complete to produce a chiral conducting polymer, e.g., polyaniline. A preferred process includes addition of a catalyst during the reaction, the catalyst selected from among the group consisting of phenylene diamine, aniline oligomers and amino-capped aniline oligomers and metal salts. n The processes of the present invention further provide a resultant polyaniline product having a chirality level defined by a molar ellipticity of from about 40×10 3 degree-cm 2 /decimole to about 700×10 3 degree-cm 2 /decimole. The processes of the present invention further provide a resultant polyaniline product having a nanofiber structure with a diameter of from about 30 nanometers to about 120 nanometers and from about 1 micron to about 5 microns in length.

专利号:US-7838053-B2
优先权日:2004-03-11
标题:Barley for production of flavor-stable beverage
发明人：BREDDAM KLAUS; OLSEN OLE; SKADHAUGE BIRGITTE; LOK FINN; KNUDSEN SOEREN; BECH LENE MOELSKOV
权利人:CARLSBERG AS
摘要:According to the invention, there is provided null-LOX-1 barley and plant products produced thereof, such as malt manufactured by using barley kernels defective in synthesis of the fatty acid-converting enzyme lipoxygenase-1. Said enzyme accounts for the principal activity related to conversion of linoleic acid into 9-hydroperoxy octadecadienoic acid, a lipoxygenase pathway metabolite, which-through further enzymatic or spontaneous reactions-may lead to the appearance of trans-2-nonenal. The invention enables brewers to produce a beer devoid of detectable trans-2-nonenal-specific off flavors, even after prolonged storage of the beverage.

专利号:US-6372904-B2
优先权日:1997-11-13
标 题 :Process for manufacture of in vivo stain composition
发明人：BURKETT DOUGLAS D
权利人:ZILA INC
摘要:A process for synthesizing 2-amino-5-dimethlyaminophenyl thiosulfonic acid comprises the step of oxidizing N,N'-dimethyl-rho-phenylene-diamine in the presence of a source of thiosulfate ions, while maintaining the temperature of the reaction mixture not higher than about 10° C. This compound is useful as an intermediate in the synthesis of toluidine blue O. A process for manufacturing toluidine blue O with improved yield, includes the step of preparing the intermediate 2-amino-5-diethylaminopropyl thiosulfonic acid according to the above described procedure.

专利号:US-9363959-B2
优先权日:2008-12-30
标 题 :Barley with reduced lipoxygenase activity and beverage prepared therefrom
发明人：SKADHAUGE BIRGITTE; LOK FINN; BREDDAM KLAUS; OLSEN OLE; BECH LETTE MØLSKOV; KNUDSEN SØREN
权利人:SKADHAUGE BIRGITTE; LOK FINN; BREDDAM KLAUS; OLSEN OLE; BECH LETTE MØLSKOV; KNUDSEN SØREN; CARLSBERG BREWERIES AS; HEINEKEN SUPPLY CHAIN BV
摘要:According to the invention, there is provided barley with total loss of functional lipoxygenase (LOX)-1 and LOX-2 enzymes, and plant products produced thereof, such as malt manufactured by using barley kernels defective in the synthesis of the fatty acid-dioxygenating enzymes LOX-1 and LOX-2. Said enzymes account for the principal activities related to dioxygenation of linoleic acid into 9- and 13-hydroperoxy octadecadienoic acid, respectively. 9-Hydroperoxy octadecadienoic acid represents a LOX pathway metabolite, which—through further enzymatic or spontaneous reactions—may lead to the appearance of trans-2-nonenal (T2N). The invention enables brewers to produce a beer having insignificant levels of stale, T2N-specific off-flavors, even after prolonged storage of the beverage.