合成目标产物 Isopropyl Acetoacetate 主要起始原料 Acetyl Ketene And Isopropyl Alcohol
(文献来源)合成步骤主要原料 Acetyl Ketene 和 Isopropyl Alcohol
醋酸异丙酯置于sodium体系中,化学反应生成 乙酰乙酸异丙酯 参考文献:Moureu; Delange,Comptes Rendus Hebdomadaires Des Seances De L'Academie Des Sciences,1902,Vol. 134,P. 46 标题:Moureu; Delange,Comptes Rendus Hebdomadaires Des Seances De L'Academie Des Sciences,1902,Vol. 134,P. 46
专利号:WO-2016173960-A1 优先权日:2015-04-29 标 题 :Optimized synthesis of pregabalin and 4-aminobutane acid using an improved method for producing conjugated nitroalkenes 发明人:STUMPF MARCUS 权利人:K H S PHARMA HOLDING GMBH 摘要:The invention relates to an optimized synthesis of pregabalin and additional 4-aminobutane acids using an improved method for producing conjugated nitroalkenes. This is achieved by a nitro-aldol reaction of an aliphatic aldehyde with a nitroalkane in the presence of a suitable diamine directly followed by an elimination of the conjugated nitroalkene by adding an acid, a subsequent catalyzed asymmetrical 1,4-Michael addition of a suitable nucleophile, and a subsequent retro-Claisen reaction or a hydrolosis and decarboxylation with a concluding reduction to 4-aminobutane acid.
专利号:CN-116904543-A 优先权日:2023-09-07 标 题:Application and synthesis method of a dehydrogenase in the synthesis of R-configuration Boseine
专利号:WO-2011138250-A1 优先权日:2010-05-03 标题 :Process for the preparation of 3-(4-pyridinyl)-propanol and intermediates useful in its synthesis 发明人:ATTOLINO EMANUELE; DE MARCO ALESSANDRO; ALLEGRINI PIETRO 权利人:DIPHARMA FRANCIS SRL; ATTOLINO EMANUELE; DE MARCO ALESSANDRO; ALLEGRINI PIETRO 摘要:A process for the preparation of 3-(4-pyridinyl)-propanol or a salt thereof and intermediates useful in its synthesis.
专利号:CN-116904543-B 优先权日:2023-09-07 标 题:Application and synthesis method of a dehydrogenase in the synthesis of R-configuration Boseine
专利号:US-2006035950-A1 优先权日:2004-08-09 标 题:Novel processes for preparing substantially pure anastrozole 发明人:ALNABARI MOHAMMED; FREGER BORIS; ARAD ODED; ZELIKOVITCH LIOR; SERYI YANA; DANON EDNA; DAVIDI GUY; KASPI JOSEPH 权利人:ALNABARI MOHAMMED; FREGER BORIS; ARAD ODED; ZELIKOVITCH LIOR; SERYI YANA; DANON EDNA; DAVIDI GUY; KASPI JOSEPH 摘要:The present invention provides novel processes for purifying anastrozole, devoid of using liquid chromatography. The purification processes are via the isolated anastrozole salt forms, either by crystallization or by selective acidic extractions, and optionally in both cases, converting the purified anastrozole salt to anastrozole base. Also provided is an improved process for the synthesis of anastrozole, which is obtained by alkylating the isolated and purified starting material 3,5-bis(2-cyanoprop-2-yl)benzylbromide, the process being devoid of using toxic, hazardous and environmental unfriendly solvents and reagents.
专利号:US-2017210756-A1 优先权日:2013-12-23 标题 :Synthesis of an antiviral compound
[参考文献]: M M V Ramana, Et Al. Synthesis Of A Novel 4H-Pyran Analog As Minor Groove Binder To Dna Using Ethidium Bromide As Fluorescence Probe. Spectrochim Acta A Mol Biomol Spectrosc. 2016 Jan 5:152:165-71.
合成参考文献
摘要:Sainsbury, M., Science of Synthesis Knowledge Updates, (2010) 1, 255. 摘要:Sharma, U.; Kumar, R.; Gupta, S. S.; Chandra, D., Science of Synthesis Knowledge Updates, (2022) 2, 197. 摘要:Götzinger, A. C.; Müller, T. J. J., Science of Synthesis Knowledge Updates, (2017) 3, 29. 摘要:Sharma, U.; Kumar, R.; Gupta, S. S.; Chandra, D., Science of Synthesis Knowledge Updates, (2022) 2, 142. 摘要:Sharma, U.; Kumar, R.; Gupta, S. S.; Chandra, D., Science of Synthesis Knowledge Updates, (2022) 2, 154.