CAS: 583-70-0; 2,4-Dimethylbromobenzene

上下游产品

CAS号108-38-3 间二甲苯 | CAS号135033-46-4 5-bromo-6,8-dim... | CAS号87241-52-9 (2,4-dimethylph... | CAS号95-68-1 2,4-二甲基苯胺 | CAS号593-53-3 氟甲烷 | CAS号106-38-7 对溴甲苯 | CAS号95-46-5 2-溴甲苯 | CAS号576-22-7 2-溴间二甲苯 | CAS号111192-85-9 (2,4-二甲基苯基)-磷酸 | CAS号556-96-7 5-溴间二甲苯 | CAS号576-22-7 2-溴间二甲苯 | CAS号108-38-3 间二甲苯 | CAS号49676-42-8 三(2,4-二甲苯基)膦 | CAS号141763-00-0 1-bromo-2,4-dim... | CAS号183313-49-7 2-(2,4-dimethyl... | CAS号611-01-8 2,4-二甲基苯甲酸 | CAS号34589-46-3 2,4-二甲苯基溴化镁 | CAS号27561-51-9 1-溴-4-(溴甲基)-2-甲苯

间二甲苯置于n-溴代丁二酰亚胺(Nbs),Trityl Tetrafluoroborate体系中,用 二氯甲烷,乙腈 作为反应溶剂,以70%的收率获得产物2,4-二甲基溴苯
参考文献:碳氢化合物催化烷基芳烃的溴化,Sp3 Vs.Sp2 Chh的化学选择性.
标题:碳氢化合物催化烷基芳烃的溴化,Sp3 Vs.Sp2 Chh的化学选择性.
摘要:在温和的条件下,光诱导的烷基芳烃的苄基溴化反应证明了三苯甲基阳离子(trbf 4)作为高效的路易斯酸有机催化剂的多功能性.使用n-溴代琥珀酰亚胺(nbs)作为溴化剂,该反应在环境温度下于普通遮光罩(55 W荧光灯)下进行,催化剂负载量低至2.0 Mol%.该方案适用于多种底物,以高至极好的收率得到苄基溴.与大多数以前报道的策略相反,该协议不需要任何自由基引发剂或大量加热.对于富含电子的烷基芳烃,三苯甲基离子催化的溴化反应可轻松地在苄基sp 3 Ch功能和芳烃之间切换通过简单地交替使用溶剂即可实现sp 2 Ch功能化.这种化学选择性开关可实现较高的底物控制,并易于分别制备苄基溴和溴芳烃.化学选择性开关还用于1-甲基萘的一锅反应中,以直接引入sp 3 C-Br和sp 2 C-Br官能团.
DOI:10.1002/adsc.201800788

专利信息

专利号:WO-2014191548-A1
优先权日:2013-05-31
标题:New process for the synthesis of 1-(2-((2,4-dimethylphenyl)thio)phenyl)piperazine
发明人：ZUPANCIC BORUT
权利人:LEK PHARMACEUTICALS
摘要:The present invention provides a new synthetic process for the production of 1-(2-((2,4-dimethylphenyl)thio)phenyl)piperazine (vortioxetine), an experimental drug under development for the treatment of depression and anxiety, which comprises the reaction of a compound of formula (VII), or salt thereof, (VII) wherein Q represents S, SO or SO 2 and LG represents a leaving group, with a compound of formula (XI), or salt thereof, (XI) wherein Z represents hydrogen or a protecting group. New intermediate compounds are also provided.

专利号:US-9650337-B2
优先权日:2013-02-14
标 题 :Method of synthesising 4-piperidin-4-yl-benzene-1,3-diol and the salts of same and novel compound tert-butyl 4-(2,4-dihydroxy-phenyl)-4-hydroxy-piperidine-1-carboxylate
发明人：BOITEAU JEAN-GUY; MUSICKI BRANISLAV
权利人:GALDERMA RES & DEV
摘要:A method is described for the synthesis of 4-piperidin-4-yl-benzene-1,3-diol of the following formula (I): n nand the pharmaceutically acceptable salts thereof. Also described, is tert-butyl 4-(2,4-dihydroxy-phenyl)-4-hydroxy-piperidine-1-carboxylate as a novel intermediate compound

专利号:US-6657068-B2
优先权日:2002-03-22
标题:Liquid phase oxidation of halogenated ortho-xylenes
发明人：COLBORN ROBERT EDGAR; HALL DAVID BRUCE; KOCH PETER; OECKEL GERALD
权利人:GEN ELECTRIC
摘要:A method for the manufacture of halophthalic acid by liquid phase oxidation of halo-ortho-xylene is disclosed. The halophthalic acid may be dehydrated to form halophthalic anhydride which is useful in the synthesis of polyetherimide.

专利号:US-6649773-B2
优先权日:2002-03-22
标题:Method for the manufacture of halophthalic acids and anhydrides
发明人：COLBORN ROBERT EDGAR; HALL DAVID BRUCE; KOCH PETER; OECKEL GERALD
权利人:GEN ELECTRIC
摘要:A method for the manufacture of halophthalic acid by liquid phase oxidation of halo-ortho-xylene is disclosed. The halophthalic acid may be dehydrated to form halophthalic anhydride which is useful in the synthesis of polyetherimide.

专利号:US-6657067-B2
优先权日:2002-03-22
标题 :Method for the manufacture of chlorophthalic anhydride
发明人：COLBORN ROBERT EDGAR; HALL DAVID BRUCE; KOCH PETER; OECKEL GERALD
权利人:GEN ELECTRIC
摘要:A method for the manufacture of chlorophthalic acid by liquid phase oxidation of chloro-ortho-xylene is disclosed. The chlorophthalic acid may be dehydrated to form chlorophthalic anhydride which is useful in the synthesis of polyetherimide.

专利号:US-9868747-B2
优先权日:2014-02-18
标题:Marinopyrrole derivatives and methods of making and using same
发明人：LI RONGSHI; SEBTI SAID; LIU YAN; QIN YONG; SONG HAO; CHENG CHUNWEI
权利人:H LEE MOFFITT CANCER CT & RES; CHONGQING ZEIN PHARMACEUTICAL CO LTD
摘要:Marinopyrrole derivatives and methods for their synthesis and use are described herein. Novel cyclic and symmetric marinopyrroles with triazole substituents having antibacterial activity against resistant bacterial strains, such as MRSA are introduced. Also provided are methods of using the compounds for treating or preventing cancer and/or microbial infections.