专利号:WO-2025108575-A1 优先权日:2023-11-21 标 题:Methods of selective deprotection and synthesis of transhydrindane- skeleton-based compounds 发明人:HUBER FLORIAN MAURITIUS ERASMUS 权利人:ROCHE DIAGNOSTICS GMBH 摘要:The present invention relates to methods of selectively deprotecting a transhydrindane-skeleton-based compound comprising at least two different silyl ether groups. The present invention further relates to methods of synthesizing a Vitamin D molecule and to Vitamin D molecules obtainable by such processes. Furthermore, the present invention relates to a compound according to formula (I) comprising two different silyl ether groups, its use in the synthesis of Vitamin D molecules and to methods of producing such a compound.
专利号:US-9650330-B2 优先权日:2013-12-12 标题 :Process for the synthesis of aryl sulfones 发明人:MHASKE SANTOSH BABURAO; PANDYA VIRAT 权利人:COUNCIL SCIENT IND RES 摘要:The present patent discloses a novel, efficient and transition-metal-free room temperature single step process for synthesis of aryl sulfones and substituted aryl sulfones starting from aryl substrates.
专利号:US-2003004337-A1 优先权日:2000-05-04 标 题 :Efficient lactam synthesis 发明人:JUNG KYUNG WOON; YOON CHEOL HWAN 摘要:Lactams, libraries of lactams, and an efficient method of synthesizing a lactam, including a γ-lactam, in which an a-diazoacetamide of the general structure (I) is reacted under conditions promoting intramolecular C-H insertion, for example in the presence of a rhodium salt such as Rh 2 (OAc) 4 , n n n by which means lactams that are precursors in the synthesis of diverse natural and synthetic products, including pyrrolidinone compounds such as lactacystin, pramanicin, kainic acid, statine, AHPPA, and rolipram, are produced.
专利号:WO-2005103035-A1 优先权日:2004-04-23 标题:Modified fischer indole synthesis of eletriptan 发明人:ASHCROFT CHRISTOPHER PAUL 权利人:PFIZER LTD; ASHCROFT CHRISTOPHER PAUL; PFIZER 摘要:The present invention relates to a new process for the preparation of eletriptan (I), or its enantiomer comprising a modified Fischer indole synthesis, namely the reaction of a compound of formula (II), wherein R1 is a suitable hydrazine protecting group, with a compound of formula (III) wherein R2 is an aldehyde group (-CHO) or the functional equivalent thereof.
专利号:US-6689890-B2 优先权日:2000-05-04 标 题:Efficient lactam synthesis 发明人:JUNG KYUNG WOON; YOON CHEOL HWAN 权利人:UNIV SOUTH FLORIDA 摘要:Lactams, libraries of lactams, and an efficient method of synthesizing a lactam, including a gamma-lactam, in which an alpha-diazoacetamide of the general structure (I) is reacted under conditions promoting intramolecular C-H insertion, for example in the presence of a rhodium salt such as Rh2(OAc)4,by which means lactams that are precursors in the synthesis of diverse natural and synthetic products, including pyrrolidinone compounds such as lactacystin, pramanicin, kainic acid, statine, AHPPA, and rolipram, are produced.
专利号:US-2008255359-A1 优先权日:2005-09-28 标题:Novel Chemical Process For the Synthesis of Quinoline Compounds 发明人:WADE CHARLES EDWARD 权利人:WADE CHARLES EDWARD 摘要:Disclosed is a novel, simplified and economic process for making 3-phenylsulphonyl quinolines with an amine group at position 8 of the quinoline ring system, including 3-phenylsulfonyl-8-piperazin-1-yl-quinoline in particular, in the absence of a palladium catalyst. Also disclosed is the crystallization of polymorphic forms of 3-phenylsulfonyl-8-piperazin-1-yl-quinoline.
摘要:Sartori, G.; Maggi, R., Science of Synthesis, (2010) 47, 528. 摘要:Vrána, J.; Růžička, A., Science of Synthesis Knowledge Updates, (2021) 2, 35. 摘要:Vaultier, M.; Pucheault, M., Science of Synthesis Knowledge Updates, (2012) 4, 332. 摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2010) 2, 310. 摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2010) 2, 251.