CAS: 920-66-1; 1,1,1,3,3,3-Hexafluoropropan-2-Ol

• 英文名称1,1,1,3,3,3-Hexafluoropropan-2-Ol
• 中文名称1,1,1,3,3,3-六氟丙-2-醇
• IUPAC名称1,1,1,3,3,3-hexafluoropropan-2-ol
• 其它别名1,1,1,3,3,3-六氟代-2-丙醇; Hexafluoroisopropyl Alcohol
• CAS编号920-66-1
• MFCD编号:MFCD00011651
• EINECS号:213-059-4
• FDA UNII编号:3D632GYQ50
• 分子式:C3H2F6O
• 分子量:168.0377
• 产品CID: 1958800
• 产品分类有机原料→分子砌块→脂肪链类化合物

• 相似结构搜索
• 产品信息参考;;;
• InChIKey: BYEAHWXPCBROCE-UHFFFAOYSA-N
• InChI=1S/C3H2F6O/c4-2(5,6)1(10)3(7,8)9/h1,10H…
• 计算化学: 氢键受体数1.0氢键供体数1.0可旋转键数0.0

相似化合物

物理性质

• 熔点-4°C
• 沸点59°C at 760 mmHg
• 闪点4,4°C
• 密度1.5±0.1 g/cm3
• PH:3-4 (H2O)Aqueous solution
• pKa:pK1:9.42 (25°C)
• PSA:20.23
• LogP:1.4719
• 折射率1.269
• 蒸汽压37.2±0.3 mmHg at 25°C
• 溶解性Soluble In Chloroform, Ethyl Acetate
• 敏感性常温常压下稳定，避免氧化物接触
• 外观形态白色至黄色固体
• 储存条件存储低于 +30°C.
• 产品应用该化合物用于石本/纳米散射材料.
• 性质描述熔点−4°C,沸点59°C,密度1.596g/mLat25°C,折光率n20/D1.275,闪点4.4°C

MSDS等安全信息

• GHS象形图
• GHS符号GHS08 & GHS05;
  注释: Health hazard & Corrosion
• 危险类别生殖毒性 类别2
  特定目标器官毒性-重复接触 类别2
  皮肤腐蚀 类别1A
  严重眼损伤 类别1
  皮肤腐蚀 类别1C
  急性毒性 类别4(吸入)
  急性毒性 类别4(经皮)
  急性毒性 类别4(经口)
  特定目标器官毒性 - 单次接触 类别3
  皮肤腐蚀 类别1B
  易燃液体 类别2
  易燃液体 类别3
  金属腐蚀物 类别1
  皮肤腐蚀 类别1
  急性毒性 类别3(经口)
• 警示词Danger(危险)
• 危险描述H361 |怀疑对生育能力或胎儿造成损害.
  H373 |长期或反复接触可能损害器官.
  H314 |造成严重皮肤灼伤和眼损伤.
  H318 |造成严重眼损伤.
  H332 |吸入有害.
  H312 |皮肤接触有害.
  H302 |吞咽有害.
  H335 |可能引起呼吸道刺激.
  H361d |怀疑对胎儿造成损害.
  H225 |高度易燃液体和蒸气.
  H226 |易燃液体和蒸气.
  H290 |可能对金属造成腐蚀.
  H361fd |怀疑会影响生育能力. 怀疑对胎儿造成损害.
  H301 |吞咽会中毒.
• 防范说明P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501
• 危险等级8
• UN编号1760.0
• 危险品标志C,Xi
• 风险等级Corrosive
• 包装等级Ⅰ
• 安全声明26-36/37/39-45-27
• 危险类别码20/22-34
• WGK Germany2

欧盟法规

上下游产品

合成工艺路线路线简述

• 合成目标产物 1,1,1,3,3,3-Hexafluoro-2-Propanol 主要起始原料 Chloromethyl-1,1,1,3,3,3-Hexafluoroisopropyl Ether
• 34202-69-2 = 920-66-1
  反应条件:1.1 Reagents: Hydrogen Catalysts: Ni,B Nickel Base Alloy; Rt -> 100 °C; 10 H,980.6 Kpa,95 - 100 °C
  标题:Synthesis Of Sevoflurane
  作者:Li,Bindong; Lu,Chunxu; Feng,Chao
  参考文献:Zhongguo Yiyao Gongye Zazhi 日期:2007 卷标:38(10) 页码:681-682]
  
  = 920-66-1
  反应条件:1.1 Reagents: Hydrofluoric Acid Catalysts: Chromium Trioxide; 2 H,Rt -> 80 °C1.2 Reagents: Hydrofluoric Acid Catalysts: Chromium Trioxide,Palladium Chloride; 50 Min,Rt -> 400 °C1.3 Reagents: Hydrogen; 8 H,0.6 Mpa,Rt -> 80 °C
  标题:Method For Synthesizing Hexafluoroacetone And Method For Synthesizing Hexafluoroisopropanol
  参考文献:China]
  
  = 920-66-1
  反应条件:1.1 Reagents: Hydrogen Catalysts: Ruthenium; 1 Mpa,9 °C; 1 H,12 °C -> 54 °C; 1.5 H,54 °C; 43 °C
  标题:Preparation Of Hexafluoroisopropanol By Catalytic Hydrogenation Of Hexafluoroacetone At Low Temperature
  参考文献:Japan]
  
  34202-69-2 = 920-66-1
  反应条件:1.1 Reagents: Ammonia,Phosphonic Acid Catalysts: Cupric Chloride Solvents: Water; 10 H,Reflux1.2 Reagents: Sulfuric Acid Solvents: Water
  标题:Method Of Producing Hexafluoropropanol
  参考文献:Russian Federation]
  
  = 920-66-1
  反应条件:1.1 Reagents: Sodium Dihydroethoxyethylaluminate Solvents: Benzene
  标题:Reductions By Metal Alkoxyaluminum Hydrides
  作者:Malek,Jaroslav
  参考文献:Organic Reactions (Hoboken 日期:1985 卷标:34]
  
  = 920-66-1
  反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium
  标题:Method Of Making Hydrofluorocarbons From Ketones
  参考文献:United States]
  
  = 920-66-1
  反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium (On Carbon); 3 - 4 Bar; 1 H,3 - 4 Bar
  标题:Process For Preparing Hexafluoroisopropanol By Hydrogenation Of Hexafluoroacetone
  参考文献:China]
  
  24427-67-6 = 920-66-1
  反应条件:1.1 Reagents: Hydrogen,Hydrofluoric Acid Catalysts: Palladium; 2 H,1 Mpa,30 °C
  标题:Hf-Mediated Equilibrium Between Fluorinated Ketones And The Corresponding α-Fluoroalcohols
  作者:Hayasaka,Tatsuya; Katsuhara,Yutaka; Kume,Takashi; Yamazaki,Takashi
  参考文献:Tetrahedron 日期:2011 卷标:67(12) 页码:2215-2219]
  
  34202-69-2 = 920-66-1
  反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium,Carbon; 10 Bar,383 K
  标题:Heterogeneous Continuous Flow Hydrogenation Of Hexafluoroacetone Trihydrate And Its Kinetic Modeling
  作者:Xue,Haotian; Qi,Tingting; Su,Weike; Wu,Ke-Jun; Su,An
  参考文献:Industrial & Engineering Chemistry Research 日期:2023 卷标:62(15) 页码:6121-6129]
  
  = 920-66-1
  反应条件:1.1 Catalysts: Ni 3288E; 3 H,600 Psi,120 °C
  标题:Continuous Process For Production Of Hexafluoroisopropanol
  参考文献:World Intellectual Property Organization]
  
  407588-06-1 = 920-66-1
  反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium (Supported On Coconut Husk Charcoal),Silver (Containing Palladium Or Rhodium,Supported On Coconut Husk Charcoal)
  标题:Process For Producing Fluorinated Alcohol By Esterification Of Alcohols,Fluorination Of Alcohol Esters,Decomposition Of Fluorinated Alcohol Esters To Fluorinated Ketones And Acyl Fluorides,And Catalytic Hydrogenation
  参考文献:World Intellectual Property Organization]
  
  = 920-66-1
  反应条件:1.1 Reagents: Isopropanol; 6 H,240 °C
  标题:Uncatalyzed Meerwein-Ponndorf-Verley Reduction Of Trifluoromethyl Carbonyl Compounds By High-Temperature Secondary Alcohols
  作者:Lermontov,Sergei A.; Shkavrov,Sergei V.; Kuryleva,Nina V.
  参考文献:Journal Of Fluorine Chemistry 日期:2003 卷标:121(2) 页码:223-225]
  
  = 920-66-1
  反应条件:1.1 Reagents: Ammonium Formate; 105 - 110 °C; 6 H,Reflux; Reflux -> 89 °C; 89 °C -> Rt1.2 Reagents: Formic Acid; Cooled
  标题:Method Of Obtaining Hexafluoroisopropanol
  参考文献:Russian Federation]
  
  34202-69-2 = 920-66-1
  反应条件:1.1 Reagents: Hydrazine Hydrate (1:1); 30 Min,Rt; Rt -> 60 °C; 20 Min,60 °C1.2 Reagents: Hydrogen Peroxide Solvents: Water; 85 - 90 °C
  标题:Production Of Hexafluoroisopropanol By Reduction Of Hexafluoroacetone
  参考文献:Russian Federation]
  
  677-71-4 = 920-66-1
  反应条件:1.1 Reagents: Sodium Bicarbonate,Hydrogen Catalysts: Palladium,Ruthenium
  标题:Preparation Of High-Purity 1,1,1,3,3,3-Hexafluoropropan-2-Ol From Hexafluoroacetone Hydrate
  参考文献:Japan]
  
  = 920-66-1
  反应条件:1.1 Solvents: Tetrahydrofuran
  标题:Hydrogen Bonding In Fluoro Alcohols
  作者:Middleton,W. J.; Lindsey,R. V. Jr.
  参考文献:Journal Of The American Chemical Society 日期:1964 卷标:86(22) 页码:4948-52]
  
  = 920-66-1
  反应条件:1.1 Reagents: Water; 10 - 25 Min,90 - 150 °C1.2 13 - 20 Min,120 - 170 °C1.3 Reagents: Hydrogen; 20 - 42 Min,6 - 11 Mpa,120 - 170 °C
  标题:Preparation Of Hexafluoroisopropanol
  参考文献:China]
  
  = 920-66-1
  反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium; 1.5 H,180 °C
  标题:Method For Continuously Producing Hexafluoroisopropanol With Hexafluoropropylene Oxide As Raw Material
  参考文献:China]
  
  677-71-4 = 920-66-1
  反应条件:1.1 Reagents: Hydrogen Catalysts: Cobalt Dinitrate,Lanthanum,Compd. With Nickel (1:5),Sodium Borohydride; 110 °C; 1 - 3 H,200 °C
  标题:Preparation Of Hexafluoroisopropanol By Gas Phase Hydrogenation
  参考文献:China]
  
  = 920-66-1 + 115397-49-4 + 52772-37-9 + 53841-56-8 + 918-21-8
  反应条件:1.1 Reagents: Aluminum,Mercuric Chloride Solvents: Tetrahydrofuran1.2 Reagents: Sulfuric Acid Solvents: Water
  标题:Reductive Defluorination Of Hexafluoroacetone And Synthesis Of Halopentafluoroacetones
  作者:Postovoi,S. A.; Vol'Pin,I. M.; Mysov,E. I.; Ziefman,Yu. V.; German,L. S.
  参考文献:Izvestiya Akademii Nauk Sssr 日期:1989 卷标:(5) 页码:1173-6

海关参考信息

• 2905122000-异丙醇
  2903399090-其他无环烃卤化衍生物
• 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
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专利信息

其他信息查阅

• ➥ 象形图和危险代码
• ➥ 防范代码详解
• ➥ 危险代码说明
• ➥ Globally Harmonized System
• ➥ REACH监管