CAS: 920509-32-6; 2-(3,5-Dichloro-4-((5-Isopropyl-6-Oxo-1,6-Dihydropyridazin-3-yl)Oxy)Phenyl)-3,5-Dioxo-2,3,4,5-Tetrahydro-1,2,4-Triazine-6-Carbonitrile

上下游产品

(Z)-Ethyl (2-Cyano-2-(2-(3,5-Dichloro-4-((5-Isopropyl-6-Oxo-1,6-Dihydropyridazin-3-yl)Oxy)Phenyl)Hydrazono)Acetyl)Carbamate 1581304-53-1
N-(3,5-Dichloro-4-((5-Isopropyl-6-Oxo-1,6-Dihydropyridazin-3-yl)Oxy)Phenyl)Benzamide 1581304-52-0
N-(3,5-Dichloro-4-((5-Isopropyl-6-Oxo-1,6-Dihydropyridazin-3-yl)Oxy)Phenyl)Acetamide 1581304-51-9
6-（4-氨基-2,6-二氯苯氧基）-4-异丙基哒嗪-3（2H）-酮 6-(4-Amino-2,6-Dichlorophenoxy)-4-Isopropylpyridazin-3(2H)-One 920509-28-0

3,5-Dichloro-4-((6-Chloropyridazin-3-yl)Oxy)Aniline置于盐酸,水,Potassium Acetate,溶剂黄146,Lithium Chloride,Potassium Hydroxide,Sodium Nitrite体系中,用 四氢呋喃,N,N-二甲基乙酰胺,水 作为反应溶剂,化学反应 14.01H,反应生成 2-(3,5-二氯-4-((5-异丙基-6-氧代-1,6-二氢哒嗪-3-基)氧基)苯基)-3,5-二氧基-2,3,4,5-四氢-1,2,4-三嗪-6-碳腈
参考文献: Method Of Synthesizing Thyroid Hormone Analogs And Polymorphs Thereof[fr] Procédé De Synthèse D'Analogues De L'Hormone Thyroïdienne Et De Ses Polymorphes
标题: Method Of Synthesizing Thyroid Hormone Analogs And Polymorphs Thereof[fr] Procédé De Synthèse D'Analogues De L'Hormone Thyroïdienne Et De Ses Polymorphes

专利信息

专利号:WO-2024084491-A1
优先权日:2022-10-21
标题:Process for synthesis of res metirom and its intermediates thereof
发明人：MEHTA NILESH VIPINCHANDRA
权利人:MEHTA NILESH VIPINCHANDRA
摘要:The present invention discloses a process for synthesis of Res metirom and its intermediates thereof. More particularly, the invention discloses process for synthesis of a key intermediate, 6-(4-amino, 2,6-dichlorophenoxy)4- isopropylpyridazin-3(2H)-one, of Res metirom via novel intermediate compounds of formula A. Wherein, R is selected from methyl, ethyl and propyl.

专利号:US-2018297925-A1
优先权日:2015-10-12
标题 :Methods for total synthesis of resolvin e1
发明人：JAGTAP PRAKASH
权利人:SALZMAN LOVELACE INVEST LTD
摘要:Methods for total chemical synthesis of Resolvin E1 (RvE1) include Wittig reaction of two compounds having hydroxyl protecting group in the presence of a strong base, removal of the hydroxyl-protecting groups with a deprotecting reagent to produce a compound having an ester group, and hydrolysis of the ester group to obtain RvE1

专利号:US-2005239767-A1
优先权日:2003-10-28
标题 :Intermolecular SNAr of the heterocycle-activated nitro and fluoro groups-application in the synthesis of polyazamacrocyclic ligands
发明人：CHAN MICHAEL K; FEKNER TOMASZ
权利人:CHAN MICHAEL K; FEKNER TOMASZ
摘要:A new class of tetracylic benzimidazole compounds and derivatives thereof. Additionally provided is a synthetic route for the generation of these and related compounds via Intramolecular Aromatic Nucleophilic Substitution (S N Ar) of the Benzimidazole-Activated Nitro Groups. Additionally, a facile route for the generation of novel phenol species as thermal decomposition of compounds the S N Ar product, which occurs at high temperature resulting in cleavage of the ether linkage and formation of a vinyl group and phenol is provided. Also provided are methods of using the compounds described herein in the treatment HIV.

专利号:US-9968612-B2
优先权日:2012-09-17
标题:Method of synthesizing thyroid hormone analogs and polymorphs thereof
发明人：TAUB REBECCA; REYNOLDS CHARLES H
权利人:MADRIGAL PHARMACEUTICALS INC
摘要:The disclosure describes methods of synthesis of pyridazinone compounds as thyroid hormone analogs and their prodrugs. Preferred methods according to the disclosure allow for large-scale preparation of pyridazinone compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of pyridazinone compounds in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of a pyridazinone compound. Further disclosed is a method for treating resistance to thyroid hormone in a subject having at least one TRβ mutation.

专利号:EA-031768-B1
优先权日:2009-12-18
标题:METHODS OF SYNTHESIS OF INTERMEDIATE COMPOUNDS FOR THE APPLICATION IN THE SYNTHESIS OF DEOXIC ACID

专利号:US-11905244-B2
优先权日:2017-09-26
标题 :Chemical modulators of store-operated calcium channels and their therapeutic applications
发明人：ZHOU YUBIN; HE LIAN
权利人:TEXAS A & M UNIV SYS
摘要:Methods of identification of inhibitors of calcium release-activated calcium (CRAC) channel and small molecule inhibitors of CRAC channel, including methods of their synthesis and pharmaceutical use, are disclosed.