CAS: 1189-24-8; Diisobutyl Phosphite

相似化合物

126-71-6 513-08-6 1809-20-7

上下游产品

triisobutyl phosphite 2-methyl-propan-1-ol phosphonic acid diethyl ester propylaminetriisobutyl phosphite phosphor°Chloridic acid diisobutyl ester (α-hydroxy-3-nitro-benzyl)-phosphonic acid diisobutyl ester (1-Benzylamino-cyclohexyl)-phosphonic acid diisobutyl ester

专利信息

专利号:US-2024287520-A1
优先权日:2021-06-30
标题:Method for synthesis of linkage modified oligomeric compounds
发明人：RODRIGUEZ ANDREW A
权利人:IONIS PHARMACEUTICALS INC
摘要:The present disclosure provides methods of synthesizing modified oligonucletodies and oligomeric compounds (including oligomeric compounds that are antisense agents or portions thereof) comprising a modified oligonucleotide having at least one modified internucleoside linking group. In certain embodiments, the present disclosure provides stabilized formulations of certain sulfonyl azides for use in the synthesis of olignonucleotides comprising one or more sulfonyl phosphoramidate linkages. Some embodiments provide stabilized compositions of high energy reagents that may be used in the synthesis of modified oligonucleotides, allowing for safe process scale preparation thereof.

专利号:US-4092316-A
优先权日:1975-02-03
标题:Synthesis of C-alkyl-triethylenediamines
发明人：NIEH EDWARD C Y
权利人:TEXACO DEVELOPMENT CORP
摘要:A liquid phase synthesis of C-alkyl-triethylenediamines involves heating to elevated temperatures of from about 200° C to 300° C a suitable N-(2-hydroxyalkyl) piperazine feedstock in the presence of a catalytic amount of a pentavalent acidic phosphorus compound and then recovering the C-alkyl-triethylenediamine product from the resulting reaction product mixture.

专利号:US-2022251128-A1
优先权日:2019-05-17
标 题:Synthesis of oligomeric compounds comprising phosphorothioate diester and phosphodiester linkages
发明人：MCPHERSON ANDREW K; RODRIGUEZ ANDREW A; CAPALDI DANIEL C
权利人:IONIS PHARMACEUTICALS INC
摘要:The present disclosure provides methods for synthesizing oligomeric compounds having at least one phosphorothioate diester linkage and at least one phosphate diester internucleoside linkage. In certain embodiments, the present disclosure provides oxidation reagents that produce low amounts of unwanted phosphate diester impurities in oligomeric compounds having at least one phosphorothioate diester linkage and at least one phosphate diester internucleoside linkage.

专利号:WO-2020236618-A1
优先权日:2019-05-17
标题 :Synthesis of oligomeric compounds comprising phosphorothioate diester and phosphate diester linkages

专利号:WO-2023278589-A1
优先权日:2021-06-30
标题:Method for synthesis of linkage modified oligomeric compounds

专利号:EP-4363572-A1
优先权日:2021-06-30
标 题:Method for synthesis of linkage modified oligomeric compounds