CAS: 13115-71-4; (S)-5-Amino-2-(2-Aminoacetamido)-5-Oxopentanoic Acid

相似化合物

172669-64-6 115588-13-1 7412-78-4

上下游产品

CAS号4652-65-7 N-苄氧羰基-L-谷氨酸- 5-甲酯

Carbobenzoxy-Glycyl-<α-P-Nitro-Benzyl,γ-Methyl>-L-Glutamat置于palladium On Activated Charcoal Ammonium Hydroxide,氢气体系中,用 甲醇,水 用作溶剂,化学反应生成甘氨酰-L-谷氨酰胺一水合物
参考文献:Studies Of The Synthesis Of Peptides Containingc-Terminal Glutamine. Ii The Synthesis And Use Of α-P-Nitrobenzyl γ-Methyl L-Glutamate
标题:Studies Of The Synthesis Of Peptides Containingc-Terminal Glutamine. Ii The Synthesis And Use Of α-P-Nitrobenzyl γ-Methyl L-Glutamate
摘要:
Doi:10.1246/bcsj.37.200

专利信息

专利号:US-2002049303-A1
优先权日:1999-06-28
标 题 :Catalytically active recombinant memapsin and methods of use thereof
发明人：TANG JORDAN J N; LIN XINLI; KOELSCH GERALD; HONG LIN
摘要:Methods for the production of purified, catalytically active, recombinant memapsin 2 have been developed. The substrate and subsite specificity of the catalytically active enzyme have been determined. The substrate and subsite specificity information was used to design substrate analogs of the natural memapsin 2 substrate that can inhibit the function of memapsin 2. The substrate analogs are based on peptide sequences, shown to be related to the natural peptide substrates for memapsin 2. The substrate analogs contain at least one analog of an amide bond which is not capable of being cleaved by memapsin 2. Processes for the synthesis of two substrate analogs including isosteres at the sites of the critical amino acid residues were developed and the substrate analogs, OMR99-1 and OM99-2, were synthesized. OM99-2 is based on an octapeptide Glu-Val-Asn-Leu-Ala-Ala-Glu-Phe (SEQ ID NO:28) with the Leu-Ala peptide bond substituted by a transition-state isostere hydroxyethylene group (FIG. 1 ). The inhibition constant of OM99-2 is 1.6×10 −9 M against recombinant pro-memapsin 2. Crystallography of memapsin 2 bound to this inhibitor was used to determine the three dimensional structure of the protein, as well as the importance of the various residues in binding. This information can be used by those skilled in the art to design new inhibitors, using commercially available software programs and techniques familiar to those in organic chemistry and enzymology, to design new inhibitors to memapsin 2, useful in diagnostics and for the treatment and/or prevention of Alzheimer's disease.

专利号:US-9995750-B2
优先权日:2013-12-05
标 题:Methods of detecting and measuring glutamine and analogues thereof, and methods related thereto
发明人：ACKERLEY DAVID FRANCIS; BROWN ALISTAIR SINCLAIR; ROBINS KATHERINE JANE
权利人:VICTORIA LINK LTD
摘要:Method for the detection of glutamine and its analogs are provided by the present disclosure. Also provided are methods for measuring the levels of glutamine and its analogs, including diagnostic methods. Further provided are methods that utilize glutamine analogs for the synthesis of colored pigments and other useful agents. The methods comprise the use of a nonribosomal peptide synthetase (NRPS) under conditions to produce an indigoidine or indigoidine-related pigment.

专利号:US-7993923-B2
优先权日:2004-12-14
标题:Peptide fractions promoting growth and synthesis of desired product(S) into cell and/or tissue culture
发明人：MARC ANNIE; GOERGEN JEAN-LOUIS; FARGES-HADDANI BERANGERE
权利人:PF MEDICAMENT; CENTRE NAT RECH SCIENT
摘要:The invention relates to preparing and/or supplementing a cell or tissue culture medium. In particular, said invention relates to a serum-free and/or protein-free cell culture medium comprising peptide fractions isolated from rapeseeds, in particular rapeseeds cakes. A method for the production of a cell culture comprising said peptide fractions and for the use thereof is also disclosed.

专利号:US-7163917-B2
优先权日:2002-06-17
标 题:Synthesis method of alanylglutamine
发明人：ZHAO YUFEN; TANG GUO; ZHOU NING; HU LIMING; CHEN YONG
权利人:ZHAO YUFEN; TANG GUO; ZHOU NING; HU LIMING; CHEN YONG
摘要:A synthesis method of alanyl-glutamine includes the steps of: The N-terminal protected alanine reacts with triphenylphosphine and hexachloroethane in organic solvent to form active ester, the active ester reacts with glutamine in a solution mixture containing organic solvent and aqueous solution of inorganic base, the resultant mixture is acidified with inorganic acid, and then the N-terminal protecting group is removed. In this method, the raw materials are cheap, the synthesis technique is simple, no disposals of separation and purification are needed, the product is easy to be separated and purified, the toxicities of all the reagents used in the course of production are minimal, it is advantageous to environment protection.

专利号:US-2018147294-A1
优先权日:2013-06-06
标 题:Antibody-drug conjugates, compositions and methods of use
发明人：JACKSON DAVID Y; HA EDWARD; PROBST GARY D
权利人:JACKSON DAVID Y; HA EDWARD; PROBST GARY D
摘要:Antibody-cytotoxin antibody-drug conjugates and related compounds, such as linker-cytotoxin conjugates and the linkers used to make them, tubulysin analogs, and intermediates in their synthesis; compositions; and methods, including methods of treating cancers.

专利号:WO-2009056901-A1
优先权日:2007-10-31
标题:Cyclodipeptide synthases (cdss) and their use in the synthesis of linear dipeptides