专利号:US-10112955-B2 优先权日:2015-10-29 标题 :Isoindoline, azaisoindoline, dihydroindenone and dihydroazaindenone inhibitors of Mnk1 and Mnk2 发明人:SPRENGELER PAUL A; REICH SIEGFRIED H; ERNST JUSTIN T; WEBBER STEPHEN E; SHAGHAFI MIKE; MURPHY DOUGLAS; TRAN CHINH 权利人:EFFECTOR THERAPEUTICS INC 摘要:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. n nFor Formula I compounds A 1 , A 2 , A 3 , A 4 , A 5 , W 1 , Y, R 1 , R 2 , R 3 , R 4 , R 5 , R 6a , R 6b , R 7 , R 8 , R 8a , R 8b , R 9 , R 9a , R 9b , and R 10 and subscript “nâ€? are as defined in the specification. The inventive Formula I compounds are inhibitors of Mnk and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.
专利号:EP-3070087-B1 优先权日:2011-08-05 标题 :Intermediates for the synthesis of cyclic p1 linkers as factor xia inhibitors
专利号:EP-3070087-A1 优先权日:2011-08-05 标 题 :Intermediates for the synthesis of cyclic p1 linkers as factor xia inhibitors
专利号:ES-2733096-T3 优先权日:2011-08-05 标题:Intermediaries for the synthesis of cyclic P1 linkers as XIA factor inhibitors
参考文献:10.1038/ncomms6707 摘要:Long R, Huang J, Shao W, Liu S, Lan Y, Gong J, Yang Z. Asymmetric total synthesis of (-)-lingzhiol via a Rh-catalysed [3+2] cycloaddition. Nat Commun. 2014 Dec 08;5():5707. doi: 10.1038/ncomms6707.