CAS: 18444-66-1; (R,E)-6-((8S,9R,10R,13R,14S,16R,17R)-2,16-Dihydroxy-4,4,9,13,14-Pentamethyl-3,11-Dioxo-4,7,8,9,10,11,12,13,14,15,16,17-Dodecahydro-3H-Cyclopenta[a]Phenanthren-17-yl)-6-Hydroxy-2-Methyl-5-Oxohept-3-En-2-Yl Acetate

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CAS号2222-07-3 葫芦素 I

葫芦素 B置于溴苯,N,N-二甲基乙酰胺,Sodium Acetate,Palladium Diacetate体系中,化学反应 24.0H,反应生成葫芦素 E
参考文献:Cucurbitacin D Is A Disruptor Of The Hsp90 Chaperone Machinery
标题:Cucurbitacin D Is A Disruptor Of The Hsp90 Chaperone Machinery
摘要:Heat Shock Protein 90 (Hsp90) Facilitates The Maturation Of Many Newly Synthesized And Unfolded Proteins (Clients) Via The Hsp90 Chaperone Cycle,In Which Hsp90 Forms A Heteroprotein Complex And Relies Upon Cochaperones,Immunophilins,Etc.,For Assistance In Client Folding. Hsp90 Inhibition Has Emerged As A Strategy For Anticancer Therapies Due To The Involvement Of Clients In Many Oncogenic Pathways. Inhibition Of Chaperone Function Results In Client Ubiquitinylation And Degradation Via The Proteasome,Ultimately Leading To Tumor Digression. Small Molecule Inhibitors Perturb Atpase Activity At The N-Terminus And Include Derivatives Of The Natural Product Geldanamycin. However,N-Terminal Inhibition Also Leads To Induction Of The Pro-Survival Heat Shock Response (Hsr),In Which Displacement Of The Hsp90-Bound Transcription Factor,Heat Shock Factor-1,Translocates To The Nucleus And Induces Transcription Of Heat Shock Proteins,Including Hsp90. An Alternative Strategy For Hsp90 Inhibition Is Disruption Of The Hsp90 Heteroprotein Complex. Disruption Of The Hsp90 Heteroprotein Complex Is An Effective Strategy To Prevent Client Maturation Without Induction Of The Hsr. Cucurbitacin D,Isolated From Cucurbita Texana,And 3-Epi-Isocucurbitacin D Prevented Client Maturation Without Induction Of The Hsr. Cucurbitacin D Also Disrupted Interactions Between Hsp90 And Two Cochaperones,Cdc37 And P23.
Doi:10.1021/acs.Jnatprod.5B00054

专利信息

专利号:CN-110317829-B
优先权日:2016-12-08
标 题:Transcription factor participating in regulation and control of synthesis of muskmelon bitter principle and application thereof

专利号:CN-103483435-B
优先权日:2013-08-26
标题:Gene Clusters Involved in the Synthesis of Cucurbitacin C in Cucumber and Its Application

专利号:CN-103483435-A
优先权日:2013-08-26
标题 :Gene Clusters Involved in the Synthesis of Cucurbitacin C in Cucumber and Its Application

专利号:CN-105039274-A
优先权日:2015-07-13
标 题:Gene clusters involved in the synthesis of cucurbitacin E in watermelon and their application