CAS: 2459-05-4; (E)-4-Ethoxy-4-Oxobut-2-Enoic Acid

上下游产品

CAS号2459-05-4 富马酸单乙酯 | CAS号623-73-4 重氮乙酸乙酯 | CAS号126580-11-8 ethyl i-propeny... | CAS号108-31-6 顺酐 | CAS号924-44-7 乙醛酸乙酯 | CAS号3095-95-2 二乙基磷乙酸 | CAS号623-91-6 富马酸二乙酯 | CAS号141-78-6 乙酸乙酯 | CAS号110-16-7 马来酸 | CAS号64-17-5 乙醇 | CAS号108-31-6 顺酐 | CAS号2960-66-9 反式-4-氧基-2-丁烯酸乙酯 | CAS号1070-34-4 琥珀酸单乙酯 | CAS号82639-46-1 3,7,10-trimethy... | CAS号2459-05-4 富马酸单乙酯 | CAS号14369-94-9 4-Oxoheptanoic ... | CAS号139115-67-6 ethyl 4-(2-iodo... | CAS号138710-30-2 ethyl 4-oxo-4-(... | CAS号26367-48-6 富马酸单乙酯酰氯 | CAS号14794-31-1 丁二酸单乙酯酰氯

富马酸二乙酯置于candida Antarctica Lipase,水体系中,用 1,4-二氧六环 用作溶剂,化学反应 144.0H,以78%的收率获得富马酸单乙酯
参考文献:富马酸二乙酯的酶促选择性转化
标题:富马酸二乙酯的酶促选择性转化
摘要:南极假丝酵母脂肪酶在有机溶剂中选择性催化富马酸二乙酯的转化.在这些酶促反应中可以成功地使用包括氨在内的一系列氮亲核试剂,可以以高到中等的收率获得单酰胺和一酰肼.相反,马来酸二乙酯不是该酶的合适底物.
Doi:10.1016/0040-4020(95)00391-K

专利信息

专利号:US-9193691-B2
优先权日:2012-04-27
标题:Methods for the synthesis of activated ethylfumarates and their use as intermediates
发明人：KRAFT KELLY SULLIVAN; FREEMAN JOHN J; SERWINSKI PAUL; PAVIA VINNIE; PHANSTIEL OTTO; KAUR NAVNEET
权利人:MANNKIND CORP; MANNKIND CORP
摘要:Disclosed embodiments relate to improved methods for the synthesis of activated fumarate intermediates and their use in chemical synthesis. Disclosed embodiments describe the synthesis of activated fumarate esters including those derived from activating groups including: 4-nitrophenyl, diphenylphosphoryl azide, pivaloyl chloride, chlorosulfonyl isocyanate, p-nitrophenol, MEF, trifluoroacetyl and chlorine, for example, ethyl fumaroyl chloride and the subsequent use of the activated ester in situ. Further embodiments describe the improved synthesis of substituted aminoalkyl-diketopiperazines from unisolated and unpurified intermediates allowing for improved yields and reactor throughput.

专利号:US-7417142-B2
优先权日:2002-03-28
标 题:Chiral porphyrins, chiral metalloporphyrins, and methods for synthesis of the same
发明人：ZHANG X PETER; CHEN YING; GAO GUANG-YAO
权利人:UNIV TENNESSEE RES FOUNDATION
摘要:Novel methods of synthesizing heteroatom-containing chiral porphyrins and chiral metalloporphyrins and the novel chiral porphyrins and chiral metalloporphyrins themselves are disclosed. Metal complexes of the chiral porphyrins are prepared in high yields and shown to be active catalysts for highly enantioselective and diastereoselective cyclopropanation, aziridination, and epoxidation of alkenes under a practical one-pot protocol.

专利号:WO-2024118348-A1
优先权日:2022-11-29
标 题:Processes and intermediates for synthesis of mrtx0902
发明人：SCATTOLIN THOMAS; CHEN CHENG; ACHMATOWICZ MICHAL
权利人:MIRATI THERAPEUTICS INC
摘要:The present invention relates to new synthetic routes of manufacturing MRTX0902. The invention also provides intermediates used in the provided synthetic routes, and the fumarate salt of MRTX0902.

专利号:US-5629394-A
优先权日:1992-12-17
标 题 :Direct synthesis by living cationic polymerization of nitrogen-containing polymers
发明人：CHERADAME HERVE M; CHEN FRANK J; STANAT JON E R; NGUYEN HUNG A; TABAR BEHROOZ R
权利人:EXXON CHEMICAL PATENTS INC
摘要:A method is provided for the direct synthesis by living cationic polymerization of novel polymeric materials functionalized with desirable nitrogen-containing functional groups such as terminal azido, cyano, carbonylamino, cyanato, thiocyanato or thiocarbonylamino groups. Polymerization and functionalization occur in a substantially simultaneous manner. All necessary reactants for the functionalization are present when polymerization is initiated. The nitrogen-containing functional group is provided as a part of a molecule having a release moiety which is preferably resonance stabilized or a tertiary alkyl type and which acts to aid the nitrogen-containing species in functioning as a leaving group.

专利号:US-6203720-B1
优先权日:1996-12-24
标题 :Low MFT and high Tg , internally plasticizing, and low voc latex compositions
发明人：THAMES SHELBY FRELAND; PANJNANI KAMLESH GOPICHAND; HARIHARAN RAJAN; WANG ZHIYU
权利人:UNIV SOUTHERN MISSISSIPPI
摘要:Novel latex or emulsion compositions containing internally plasticizing and crosslinkable monomers derived from traditional semi-drying or non-drying oils are disclosed and claimed. The monomers are ethylenically unsaturated esters of long-chain olefinic compounds. Preferred embodiments include latex formed from acrylate or methacrylate esters of hydroxy fatty acid esters derived from castor oil or lesquerella oil. A process for the synthesis of the latex composition is also disclosed, which involves (a) an esterification reaction of ethylenically unsaturated carboxylic acid or its derivatives with a substituted hydroxy long-chain olefinic compound; (b) subsequent polymerization of the so formed ethylenically unsaturated ester of a long-chain olefinic compound in an aqueous phase with at least one other copolymerizable monomer; and (c) blending so formed polymer with at least one drier and a surfactant to form the novel latex or emulsion compositions. These compositions form films at low minimum film forming temperatures (MFT) ranging from −5 to 10° C. and cure to above ambient glass transition (T g ) polymers without the use of traditional organic cosolvents which contribute to environmental pollution via volatile organic compounds (VOCs) emissions. These compositions are therefore useful in waterborne coatings, contact and pressure sensitive adhesives, and inks.

专利号:US-9944669-B2
优先权日:2014-03-21
标 题:Fumarate-CO-releasing molecule hybrids, their use in the treatment of inflammatory or cardiovascular diseases and their process of preparation
发明人：MOTTERLINI ROBERTO; FORESTI ROBERTA; MARTENS THIERRY; RIVARD MICHAEL
权利人:UNIV PARIS VAL DE MARNE; CENTRE NAT RECH SCIENT; INST NAT SANTE RECH MED
摘要:The present invention relates to hybrid fumarate-CO-releasing molecules capable of increasing heme oxygenase-1 (HO-1) activity and HO-1 protein expression and simultaneously releasing CO, their synthesis and their use in therapeutic applications, in particular their use in the treatment of inflammatory or cardiovascular diseases.