CAS: 35878-28-5; Cis-Tetrahydro-1H-Cyclopenta[c]Furan-1,3(3Ah)-Dione

• 英文名称Cis-Tetrahydro-1H-Cyclopenta[c]Furan-1,3(3Ah)-Dione
• 中文名称Rac-(3ar,6as)-六氢-1h-环戊二烯[c]呋喃-1,3-二酮,顺式
• IUPAC名称cis-Tetrahydro-1H-cyclopenta[c]furan-1,3(3aH)-dione
• 其它别名1.2-环戊烷邻二甲酸酐; Cyclopentane-1,2-Dicarboxylic Acid Anhydride
• CAS编号35878-28-5
• MFCD编号:MFCD01311171
• EINECS号:252-773-0
• 分子式:C7H8O3
• 分子量:140.14
• 产品CID: 1367560
• 产品分类有机原料→分子砌块→脂肪杂环类化合物→四氢呋喃类化合物

• 相似结构搜索
• 产品信息参考;;;;
• InChIKey: NMSRALOLNIBERV-UHFFFAOYNA-N
• InChI=1S/C7H8O3/c8-6-4-2-1-3-5(4)7(9)10-6/h4-5H,1-3H2/t4-,5+…
• 计算化学: 氢键受体数3.0氢键供体数0.0可旋转键数0.0

相似化合物

物理性质

• 熔点73-74 °C
• 沸点84-86 °C at 0.5 mmHg
• 闪点140.4±15.9 °C
• 密度1.3±0.1 g/cm3
• PSA:43.37
• LogP:0.4861
• 折射率1.514
• 蒸汽压0.0±0.6 mmHg at 25°C
• 储存条件密封干燥,冷冻保存, 低于 -20°C
• 产品应用该化合物用于丙型肝炎病毒蛋白抑制剂-调聚物,NRF2-KEAP1复合抑制剂的配制,约束模式和结构活动关系合成.

MSDS等安全信息

• GHS象形图
• GHS符号GHS05;
  注释: Corrosion
• 危险类别皮肤腐蚀/刺激 类别2
  严重眼损伤 类别1
  特定目标器官毒性 - 单次接触 类别3
  严重眼刺激 类别2
• 警示词Danger(危险)
• 危险描述H315 |造成皮肤刺激.
  H318 |造成严重眼损伤.
  H335 |可能引起呼吸道刺激.
  H319 |造成严重眼刺激.
• 防范说明P264-P280-P302+P352-P362+P364
• 危险等级8
• UN编号3261.0
• 危险品标志Xi
• 包装等级Ⅲ
• 安全声明26-39
• 危险类别码38-41
• WGK Germany3

欧盟法规

上下游产品

合成工艺路线路线简述

• 1461-96-7 = 35878-28-5
  反应条件:1.1 Solvents: Acetic Anhydride
  标题:Reactivity Patterns In The Rhodium Carbenoid Induced Tandem Cyclization-Cycloaddition Reaction
  作者:Padwa,Albert; Hornbuckle,Susan F.; Fryxell,Glen E.; Stull,Paul D.
  参考文献:Journal Of Organic Chemistry 日期:1989 卷标:54(4) 页码:817-24]
  
  1461-96-7 = 35878-28-5
  反应条件:1.1 Reagents: Acetic Anhydride; 1.5 H,120 °C
  标题:Preparation Of Lactams From Cyclic Anhydrides Via N-Carboxyanhydride Intermediates
  作者:Smith,Simon N.; Connon,Stephen J.
  参考文献:European Journal Of Organic Chemistry 日期:2021 卷标:2021(40) 页码:5540-5544]
  
  285-67-6 = 35878-28-5
  反应条件:1.1 Catalysts: Phosphorus(1+),Triphenyl(P,P,P-Triphenylphosphine Imidato-Kn)-,(T-4)-,Azide (...,(-)-Chloro[[2,2′-[(1R,2R)-1,2-Cyclohexanediylbis[(Nitrilo-Kn)Methylidyne]]Bis[4,... Solvents: Dichloromethane; 30 Min,Rt1.2 3 H,3.5 Mpa,Rt -> 80 °C
  标题:Catalytic Coupling Of Cyclopentene Oxide And Co2 Utilizing Bifunctional (Salen)Co(Iii) And (Salen)Cr(Iii) Catalysts: Comparative Processes Involving Binary (Salen)Cr(Iii) Analogs
  作者:Darensbourg,Donald J.; Chung,Wan-Chun; Wilson,Stephanie J.
  参考文献:Acs Catalysis 日期:2013 卷标:3(12) 页码:3050-3057]
  
  1461-96-7 = 35878-28-5
  反应条件:1.1 Solvents: Acetic Anhydride
  标题:Synthesis And Neuroleptic Activity Of Some Trans-(2-Aminomethyl)Cyclopentyl Aryl Ketones
  作者:Caamano,Olga; Fernandez,Franco; Eirin,Ana; Uriarte,Eugenio; Calleja,Jose Maria; Et Al
  参考文献:European Journal Of Medicinal Chemistry 日期:1987 卷标:22(4) 页码:311-17]
  
  17224-73-6 = 35878-28-5
  反应条件:1.1 Solvents: Acetic Anhydride
  标题:Preparation And Physical Properties Of Sulfur Compounds Related To Petroleum. V. Cis- And Trans-1-Thiahydrindan And -3-Thiabicyclo[3.3.0]Octane,And Cis-2-Thiabicyclo[3.3.0]Octane
  作者:Birch,Stanley F.; Dean,Ronald A.; Hunter,Neville J.; Whitehead,Edmund V.
  参考文献:Journal Of Organic Chemistry 日期:1955 卷标:20 页码:1178-90]
  
  285-67-6 = 35878-28-5
  反应条件:1.1 Catalysts: 3-(Dimethylamino)-1-Propanol; 3 H,1 Mpa,120 °C
  标题:The Unprecedented Catalytic Activity Of Alkanolamine Co2 Scrubbers In The Cycloaddition Of Co2 And Oxiranes: A Dft Endorsed Study
  作者:Roshan,Kuruppathparambil Roshith; Kim,Bo Mi; Kathalikkattil,Amal Cherian; Tharun,Jose; Won,Yong Son; Et Al
  参考文献:Chemical Communications (Cambridge 日期:2014 卷标:50(89) 页码:13664-13667]
  
  1461-96-7 = 35878-28-5 [标题:Reaction Conditions
  标题:Product Class 4: Carboxylic Acid Anhydrides And Their Sulfur,Selenium,And Tellurium Derivatives
  作者:Keller,P. A.
  参考文献:Science Of Synthesis 日期:2006 卷标:20 页码:617-641

海关参考信息

• 2905121000-正丙醇
  2909110000-乙醚
  2912110000-甲醛
  2912120000-乙醛
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