CAS: 481-21-0; 5α-Cholestane

上下游产品

CAS号566-88-1 5alpha-Cholesta... | CAS号2791-43-7 5α-cholestan-3-... | CAS号1255-88-5 CHOLESTANOL ACETATE | CAS号55738-55-1 cholestan-3-yl ... | CAS号57700-97-7 1-(5α-cholestan... | CAS号13901-19-4 5α-cholest-2-ene

S-Isopropyl-O-3β-Cholestanyldithiocarbonate置于三正丁基氢锡体系中,用 氘代苯 作为反应溶剂,以67%的收率获得产物5Alpha-胆甾烷
参考文献:关于仲醇通过氢化锡还原黄原酸甲酯的脱氧机理
标题:关于仲醇通过氢化锡还原黄原酸甲酯的脱氧机理
摘要:研究了关于通过三丁基锡烷还原黄药的两种替代方案.有证据表明,在正常还原条件下,硫羰基可逆地被攻击.在足够高的温度下,碳自由基断裂以最终产生还原产物.在改性条件下,不存在还原剂(sn-H)时,形成的自由基消除了甲基硫代三丁基锡,并提供了在esr光谱中观测到的硫代羰氧基基团.
DOI:10.1016/s0040-4020(01)90614-3

专利信息

专利号:WO-9419366-A1
优先权日:1993-02-26
标题 :Chemical synthesis of squalamine
发明人：MORIARTY ROBERT M; GUO LIANG; TULADHAR SUDERSAN M
权利人:MAGAININ PHARMA
摘要:Methods for the chemical preparation or synthesis of the sterol antibiotic squalamine. Preferably, the preparation is by modifying the 3-position of a 3-oxo-7α-hydroxy-24z-ether protected alcohol group-5α-cholestane with a spermidino moiety to form a 3β-spermidino-7α-hydroxy-24z-ether protected group -5α-cholestane; deprotecting the 24-position of the 3β-spermidino-7α-hydroxy-24z-ether protected group-5α-cholestane to the free hydroxyl; and sulfating the 24-position of the 3β-spermidino-7α, 24-dihydroxy-5α-cholestane.

专利号:US-4923403-A
优先权日:1984-08-16
标题:Microbiological process for degradation of steroids
发明人：FERREIRA NICOLAAS P
权利人:SOUTH AFRICAN INVENTIONS
摘要:A process for preparing 3a alpha -H-4 alpha -[3'-propionic acid]-5 alpha -hydroxy-7a beta -methyl-hexahydro-1-indanone- delta -lactone, having the formula for the chemical synthesis of a pharmaceutical steroid, which includes cultivating, in the presence of cholesterol, sitosterol, stigmasterol, or a mixture of sitosterol and sitostanol, a mutant of the parent species R. australis of the genus Rhodococcus.

专利号:US-5807834-A
优先权日:1994-09-20
标 题 :Combination of a cholesterol absorption inhibitor and a cholesterol synthesis inhibitor
发明人：MOREHOUSE LEE A
权利人:PFIZER
摘要:PCT No. PCT/IB95/00447 Sec. 371 Date Mar. 18, 1997 Sec. 102(e) Date Mar. 18, 1997 PCT Filed Jun. 7, 1995 PCT Pub. No. WO96/09827 PCT Pub. Date Apr. 4, 1996Pharmaceutical combination compositions including certain cholesterol absorption inhibitors and cholesterol synthesis inhibitors. The compositions are useful for the treatment of hypercholesterolemia and atherosclerosis.

专利号:WO-9609827-A2
优先权日:1994-09-20
标题:Combination of a cholesterol absorption inhibitor and a cholesterol synthesis inhibitor

专利号:EP-0782451-A1
优先权日:1994-09-20
标题 :Combination of a cholesterol absorption inhibitor and a cholesterol synthesis inhibitor