CAS: 5267-64-1; (R)-2-Amino-3-Phenylpropan-1-Ol

上下游产品

CAS号673-06-3 D-苯丙氨酸 | CAS号130406-30-3 Fm°C-D-苯丙氨醇 | CAS号438470-79-2 dibenzyl (R)-1-... | CAS号3182-93-2 L-苯丙氨酸乙酯盐酸盐 | CAS号13033-84-6 D-苯丙氨酸甲酯盐酸盐 | CAS号152903-44-1 (+)-(R)-2-(1-be... | CAS号2577-90-4 (S)-2-氨基-3-苯基丙酸甲酯 | CAS号6943-96-0 ethyl (2Z)-2-hy... | CAS号184363-65-3 (4R)-N-乙酰基)-4-苯... | CAS号63219-70-5 N-cbz-d-苯丙氨醛 | CAS号77184-95-3 (R)-2-BENZYL-AZ... | CAS号73058-30-7 S-2-苄基氮杂环丙烷 | CAS号58917-85-4 N-苄氧羰基-D-苯丙氨醇 | CAS号307532-06-5 (R)-(-)-2-(二苄基氨... | CAS号106454-69-7 N-B°C-D-苯丙氨醇 | CAS号130406-30-3 Fm°C-D-苯丙氨醇

D-苯丙氨酸置于sodium Tetrahydroborate,四氯化钛体系中,用 四氢呋喃 作为反应溶剂,以86%的收率获得产物d-苯丙氨醇
参考文献:用于烯烃对映选择性环氧化的均相手性锰 (Iii)-Salphe 催化剂
标题:用于烯烃对映选择性环氧化的均相手性锰 (Iii)-Salphe 催化剂
摘要:摘要 以天然氨基酸(R)-苯丙氨酸和3,5-二叔丁基-羟基苯甲醛为原料合成了一种新型手性mn(Iii)-Salphe催化剂,并应用于离子液体中未官能化烯烃的不对称环氧化反应.当 Naclo 用作氧化剂时,实现了令人满意的对映选择性 (79% < Ee < 93%) 和非常好的产率.我们发现 Ph 值 (11.3) 和反应温度 (15 oc) 对环氧化反应至关重要.在我们的反应系统中,Nh4Oac 是不必要的.我们提出 Mn(Iii)-Salphe 化合物中的醇羟基起到轴向配体的作用.然而,由于 Mn(Iii)-Salphe 化合物的结构,反应时间比使用 Jacobsen 催化剂时长,其中具有一定角度的两个醇羟基的配位几何影响接近 Mn(V) = 0 中心的底物.手性配体通过红外,紫外和可见光谱和 1 H NMR 的组合进行表征.补充材料可用于本文.转至出版商的 Synthetic Communications®
DOI:10.1080/00397911.2012.656785

专利信息

专利号:US-7189864-B2
优先权日:1990-11-19
标 题:Method of preparing intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P
权利人:SEARLE & CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.

专利号:US-2006058532-A1
优先权日:2004-09-10
标 题:Process for the scalable synthesis of 1,3,4,9-tetrahydropyrano[3,4-b]-indole derivatives
发明人：CHEW WARREN; CHEAL GLORIA K; LUNETTA JACQUELINE F; DEMERSON CHRISTOPHER A
权利人:CHEW WARREN; CHEAL GLORIA K; LUNETTA JACQUELINE F; DEMERSON CHRISTOPHER A
摘要:The invention is directed to a process of synthesizing compounds of formula (VI): n n nwherein R 1- R 9 , R 3′ , R 4′ and Y are as set forth in the specification, and said method is useful for large scale synthesis thereof. The invention is also directed to useful intermediates for synthesizing the compounds of formula (VI) and processes of preparing said intermediates.

专利号:US-6022996-A
优先权日:1990-11-19
标 题 :Method for making intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P
权利人:SEARLE & CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.

专利号:EP-0641333-B1
优先权日:1992-05-20
标 题 :Method for making intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P
权利人:SEARLE & CO; MONSANTO CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide compound of formula (I) from a chiral alpha amino aldehyde and halomethyllithium as an organometallic methylene-adding reagent. In formula (I) R<1> is selected from alkyl, aryl, cycloalkyl, cycloalkylalkyl and arylalkyl, which are optionally substituted with a group selected from alkyl, halogen, NO2, OR<9> or SR<9>, where R<9> represents hydrogen or alkyl; and P<1> and P<2> independently are selected from amine protecting groups, including but not limited to, arylalkyl, substituted arylalkyl, cycloalkenylalkyl and substituted cycloalkenylalkyl, allyl, substituted allyl, acyl, alkoxycarbonyl, aralkoxycarbonyl and silyl.

专利号:EP-0855388-B1
优先权日:1993-11-23
标 题 :Method for making intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P; FRESKOS JOHN J; DECRESCENZO GARY A; BERTENSHAW DEBORAH E; HEINTZ ROBERT M; ZHANG SUHONG; LIU CHIN; LANEMAN SCOTT A
权利人:SEARLE & CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a cyanohydrin from a chiral alpha amino aldehyde.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.