专利号:US-12076423-B2 优先权日:2015-12-23 标题 :Spiculisporic acid-based composition 发明人:AGNAOU REDA; MARION CATHERINE 权利人:OREAL 摘要:Composition in the form of an oil-in-water emulsion that includes at least 1% of an oil phase, and an aqueous phase. The composition includes 0.1 to 15 wt % spiculisporic acid relative to the total weight of the composition, at least one base selected from amino acids and alkanolamines in an amount suitable for forming at least a monosalt of spiculisporic acid, less than 3% glycol(s) and/or polyol(s) relative to the total weight of the composition, at least one UV filter and/or an additive selected from volatile aromatic materials such as essential oils and fragrance substances, fillers, dyeing materials such as pigments, mother-of-pearl or particles with a metallic sheen, moisturizers, anti-wrinkle or anti-age agents, peeling agents, antioxidants, active ingredients stimulating the synthesis of epidermal and/or dermal macromolecules, dermo-relaxing agents, depigmentation agents, deodorant agents and mixtures thereof.
专利号:US-6911318-B2 优先权日:1999-03-03 标 题:Bacterial transglycosylases: assays for monitoring the activity using Lipid II substrate analogs and methods for discovering new antibiotics 发明人:KAHNE SUZANNE WALKER 权利人:UNIV PRINCETON 摘要:This invention provides a direct method for monitoring bacterial transglycosylase activity using labeled substrates produced by chemo-enzymatic synthesis wherein the labels are selected to permit the detection of both polymeric and non-polymeric products simultaneously, either directly or following the separation of product from starting material. The invention promotes the discovery of new antibiotics with activity against bacterial transglycosylases by a) laying the groundwork for structural analysis of purified, active transglycosylase (which permits structure-based design); and b) providing an assay that can be used to screen for inhibitors.
参考文献:10.1016/j.fct.2022.113026 摘要:Api AM, Belsito D, Botelho D, Bruze M, Burton GA, Cancellieri MA, Chon H, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Jones L, Joshi K, Kumar M, Lapczynski A, Lavelle M, Lee I, Liebler DC, Moustakas H, Na M, Penning TM, Ritacco G, Romine J, Sadekar N, Schultz TW, Selechnik D, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y. RIFM fragrance ingredient safety assessment, dihydromyrcenyl acetate, CAS Registry Number 53767-93-4. Food Chem Toxicol. 2022 May;163 Suppl 1():113026. doi: 10.1016/j.fct.2022.113026.