CAS: 611-20-1; 2-Hydroxybenzonitrile

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CAS号90-02-8 水杨醛 | CAS号2042-37-7 邻溴苯腈 | CAS号95-57-8 邻氯苯酚 | CAS号557-21-1 氰化锌 | CAS号89-95-2 邻甲基苄醇 | CAS号218797-78-5 2-TERT-BUTOXY-B... | CAS号65-45-2 水杨酰胺 | CAS号119-36-8 水杨酸甲酯 | CAS号40530-18-5 5-溴-2-羟基苯甲腈 | CAS号13073-28-4 3-溴-2-羟基苯甲腈 | CAS号40718-08-9 3,5-二溴-2-羟基苯甲腈 | CAS号57805-85-3 3-氨基苯并呋喃-2-甲酸甲酯 | CAS号4481-51-0 2-(((2-hydroxyb... | CAS号49615-96-5 1-(3-氨基-1-苯并呋喃-... | CAS号39786-35-1 3-氨基苯并[b]呋喃-2-羧酸乙酯 | CAS号54802-10-7 3-氨基苯并呋喃-2-甲酰胺 | CAS号4570-41-6 2-氨基苯并恶唑 | CAS号39786-34-0 2-(2-氰基苯氧基)乙酸乙酯

水杨酸甲酯置于氨体系中,用91.6%的收率获得产物邻羟基苯甲腈
参考文献:连续固定床反应器中负载型磷酸硼催化剂由水杨酸甲酯高效制备水杨腈
标题:连续固定床反应器中负载型磷酸硼催化剂由水杨酸甲酯高效制备水杨腈
摘要:通过方便的一锅法制备了 Sio2 负载的 Bpo4 催化剂,通过 Xrd,N2 吸附/解吸,Ftir 和 Nh3-Tpd 进行了表征,并研究了以水杨酸甲酯和氨为原料在蒸汽中生产水杨腈的过程-阶段固定床工艺.结果表明,在sio2中负载bpo4可以增加表面积和表面中强酸性位点的数量,从而显着提高催化性能.详细研究了各种反应条件的影响,组成对催化活性的影响以及过程的稳定性.在优化的条件下,水杨腈的收率高达91.6%,工艺稳定性非常好.本研究将为水杨腈的工业化生产奠定基础.通过方便的一锅法制备了 Sio2 负载的 Bpo4 催化剂,在气相固定床工艺中以水杨酸甲酯和氨为原料,水杨腈的收率高达 91.6%.结果表明,在sio2中负载bpo4可以增加表面积和表面中强酸性位点的数量,显着提高催化性能.
DOI:10.1007/s11696-021-01879-2

专利信息

专利号:US-8138330-B2
优先权日:2006-09-11
标 题 :Process for the synthesis of oligonucleotides
发明人：LEUCK MICHAEL; WOLTER ANDREAS; STUMPE ALFRED
权利人:LEUCK MICHAEL; WOLTER ANDREAS; STUMPE ALFRED; SIGMA ALDRICH CO LLC
摘要:The present invention discloses novel methods for the synthesis of oligonucleotides with nucleoside phosphoramidites on solid supports. The methods comprise the stepwise chain assembly of oligonucleotides on supports with 5′-acyl phosphoramidites. The synthesis cycles consist of a front end deprotection step which is conducted with a solution of a primary amine or a phenolate, a phosphoramidite coupling step with a 5′-acyl nucleoside phosphoramidite in the presence of an activator, a phosphite oxidation step and an optional capping step. The novel methods improve the quality of synthetic oligonucleotides due to the irreversibility of the front end deprotection step, which prevents the formation of deletion sequences, and due to the avoidance of acidic reagents in the synthesis cycles, which prevent the formation of depurination side products. The invention further discloses novel nucleoside phosphoramidite compositions wherein the phosphoramidites carry acyl front end protective groups which are cleavable with primary amines or phenolates. The invention is applicable to the synthesis of oligodeoxyribonucleotides, oligoribonucleotides and oligonucleotides with modifications in their sugar or phosphate groups.

专利号:US-7576234-B2
优先权日:2002-05-15
标题 :Synthesis of 2-alkyl amino acids
发明人：CHORGHADE MUKUND S; GURJAR MUKUND K; MOHAPATRA DEBENDRA K
权利人:GENZYME CORP
摘要:Non-natural amino acids such as 2-alkylated amino acids allow for the synthesis of a wider variety of peptidal and non-peptidal pharmaceutically active agents. A method of preparing a 2-alkyl amino acid involves a Michael-type addition of a nucleophile to a dialkyl 2-methylidenylpropan-1,3-dioate and the conversion of a ester moiety into an amino moiety. The present invention also discloses a method of preparing a class of iron chelating agents related to desferrithiocin, all of which contain a thiazoline ring. In this method, an aryl nitrile or imidate is condensed with cysteine, a 2-alkyl cysteine, or a cysteine ester.

专利号:US-10927135-B2
优先权日:2017-08-03
标 题:Metal-free direct arylation of dialkyl phosphonates for the synthesis of mixed alkyl aryl phosphonates
发明人：KANG JUN YONG; HUANG HAI
权利人:THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIV OF NEVADA LAS VE
摘要:Provided herein are phosphates, thiophosphates, phosphonates, and phosphinates, methods of making same, and methods of using these compounds and methods for the generation of pharmaceutically relevant phosphate, phosphonate, and phosphinate analogs. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:WO-9845231-A1
优先权日:1997-04-09
标题:Supports for solid phase synthesis
发明人：SHAO HUI; CASTELHANO ARLINDO L
权利人:CADUS PHARMACEUTICAL CORP
摘要:Supports for solid-phase synthesis are disclosed. The supports include a phenol or thiophenol linker moiety. A substrate compound can be immobilized to the support through the linker moiety. The supports are suitable for combinatorial synthesis, including synthesis of combinatorial libraries.

专利号:US-2002042514-A1
优先权日:2000-06-26
标 题 :Synthesis of chlorinated pyrimidines
发明人：DOYLE TIMOTHY JOHN; WEHRENBERG PETER KARL; STANDEN MICHAEL CHARLES HENRY
摘要:A facile process for the preparation of 4,6-dichloropyrimidine is provided, which utilizes quaternary ammonium salts or quaternary phosphonium salts as catalysts for the reaction of, for example, 4,6-dihydroxypyrimidine or 4-chloro-6-methoxypyrimidine with phosgene.

专利号:WO-2025078335-A1
优先权日:2023-10-09
标 题 :Processes for the preparation of deucravacitinib
发明人：ETAYO PÉREZ PABLO; PUJOL OLLÉ XAVIER; MOLINA NIETO JUAN
权利人:FARMHISPANIA GROUP S L
摘要:The invention relates to processes for the preparation of deucravacitinib of formula (XI), or a pharmaceutically acceptable salt thereof. It also relates to intermediates of formula (V') and (V'') as defined herein useful in the synthesis of this molecule.