CAS: 72-14-0; 4-Amino-N-(Thiazol-2-yl)Benzenesulfonamide

上下游产品

CAS号473-42-7 硝磺胺噻唑 | CAS号121-60-8 对乙酰氨基苯磺酰氯 | CAS号127-76-4 N-(4-(N-(噻唑-2-基... | CAS号33119-99-2 methyl N-[4-(1,... | CAS号96-50-4 2-氨基噻唑 | CAS号3034-53-5 2-溴噻唑 | CAS号63-74-1 磺胺 | CAS号5664-51-7 Sulfacarzole | CAS号24939-24-0 4-氨基苯磺酰氯 | CAS号104246-27-7 2-氯-N-{4-[(1,3-... | CAS号14601-24-2 2-ethoxy-N-[4-(... | CAS号29817-67-2 Benzenesulfonam... | CAS号29817-76-3 Benzenesulfonam... | CAS号29873-34-5 2-sulfanyl-N-[4... | CAS号96-50-4 2-氨基噻唑 | CAS号85-73-4 酞磺胺噻唑 | CAS号104134-71-6 N-[4-(1,3-thiaz... | CAS号116-43-8 琥珀磺胺噻唑

对硝基苯磺酰氯置于吡啶,铁粉,氯化铵体系中,用 乙醇,水 作为反应溶剂,化学反应 22.5H,反应生成 磺胺噻唑
参考文献:作为潜在 Brafv600E 抑制剂的新型 2-乙酰氨基,6-甲酰胺取代苯并噻唑的设计和合成-其抗增殖活性的体外评价
标题:作为潜在 Brafv600E 抑制剂的新型 2-乙酰氨基,6-甲酰胺取代苯并噻唑的设计和合成-其抗增殖活性的体外评价
摘要:设计并合成了11 种新的取代苯并噻唑衍生物,以提供致癌 Brafv600E 激酶的有效抑制剂.它们在多种结直肠癌和黑色素瘤细胞系中被生物学评估为潜在的 Brafv600E 抑制剂,Mek-Erk 通路抑制剂和抗增殖剂.在所有应用的测定中,类似物2-乙酰氨基-N-[3-(吡啶-2-基氨基)丙基]苯并[d]噻唑-6-甲酰胺(22)鉴于其在药物开发中的用途提供了有希望的结果.
DOI:10.1002/cmdc.202300322

专利信息

专利号:US-10768157-B2
优先权日:2015-10-20
标 题:Materials and methods for the detection of trace amounts of substances in biological and environmental samples
发明人：KABIR ABUZAR; FURTON KENNETH G
权利人:KABIR ABUZAR; FURTON KENNETH G; THE FLORIDA INTERNATIONAL UNIV BOARD OF TRUSTEES
摘要:The subject invention provides chemical compositions and synthesis strategies to create molecularly imprinted polymers (MIPs) via sol-gel processes. In a specific embodiment, the subject invention utilizes a(n) organic, inorganic, or metallic template analyte to create a hybrid organic-inorganic or inorganic three-dimensional network possessing cavities complementary to the shape, size, and functional orientation of the template molecule or ions. The subject invention further pertains to the use of the novel MIPs as selective solid phase extraction (SPE) sorbents for pre-concentration and clean-up of trace substances in biological and environmental samples. Synthesis of other molecularly imprinted polymers with environmental, pharmaceutical, chemical, clinical, toxicological, and national security implications can be conducted in accordance with the teachings of the subject invention.

专利号:US-11958866-B1
优先权日:2023-04-07
标题:Synthesis of thiazole derivatives
发明人：NOOR AWAL; KHAN EZZAT; KHAN UMAR ALI
权利人:UNIV KING FAISAL
摘要:A synthetic protocol to use a thiourea or urea compound and auric chloride as starting materials to obtain thiazole and benzothiazole derivatives. The synthesis can be conducted at room temperature and the final compound can result from cyclization of the thiourea or urea compound in the presence of an Au salt from the auric chloride.

专利号:WO-9713503-A1
优先权日:1995-10-13
标 题:Synthesis of drug nanoparticles by spray drying
发明人：SELVARAJ ULAGARAJ; MESSING GARY L
权利人:PENN STATE RES FOUND; SELVARAJ ULAGARAJ; MESSING GARY L
摘要:The present invention relates to a method for synthesizing nanoparticles comprising combining an agent and a matrix to form a composite mixture, and spray drying the composite mixture, wherein the nanoparticles are less than about 5000 nm. Suitable agents that can be formulated into nanoparticle in the context of the present invention include therapeutic and diagnostic agents, cosmetic, dye, photographic, food, pesticide agents, among others.

专利号:US-9693999-B2
优先权日:2011-01-26
标题:Small molecule RNase inhibitors and methods of use
发明人：DUNMAN PAUL M; OLSON PATRICK D; CHILDERS WAYNE
权利人:UNIV ROCHESTER; UNIV NEBRASKA; Temple University—Of the Commonwealth System of Higher Education
摘要:Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease. Also described herein are methods of identifying compounds for treating or preventing a microbial infection.

专利号:US-9439423-B2
优先权日:2007-10-29
标 题 :Antiparasitic agent for fish and method of controlling proliferation of fish parasites
发明人：KAWANO FUMI; HIRAZAWA NORITAKA
权利人:KAWANO FUMI; HIRAZAWA NORITAKA; NIPPON SUISAN KAISHA LTD
摘要:An antiparasitic agent for fish includes an inhibitor of folate synthesis and/or an inhibitor of folate activation as the active substance(s). A combination preparation composed of an inhibitor of folate synthesis and an inhibitor of folate activation is disclosed. Sulfonamide is disclosed as suitable for the inhibitor of folate synthesis. A dihydrofolate reductase inhibitor, a folate antagonist are disclosed as suitable inhibitors of folate activation. The antiparasitic agent is able to exterminate fish parasites via oral administration. It is effective against fish parasites belonging to the ciliate group.

专利号:US-6858434-B1
优先权日:1999-10-06
标 题:Method for synthesis, separation and screening of a plurality of compounds in the same bulk of a stationary phase
发明人：WILLIAMS LORENZO
权利人:SINVENT AS
摘要:A method for sequentially performing a synthesis, separation and screening of chemical entities, especially a combinatorial library, is described. The method utilises a bulk of a stationary phase (e.g. silica gel, aluminium oxide, cellulose, etc. for example arranged on a backing) for the performance of the synthesis, separation and screening. The technique described enables a rapid route from synthesis to the testing of chemical compounds. Screening can be performed without need for reaction work-up. Preferred screening methods are those used to determine the biological activity of the compounds.