专利号:WO-2008103866-A1 优先权日:2007-02-22 标题 :Synthesis of indoles 发明人:TALLEY JOHN JEFFREY; RENZE JUERGEN T 权利人:MICROBIA INC; TALLEY JOHN JEFFREY; RENZE JUERGEN T 摘要:Method for preparing indoles, including methods that permit high yield production of particular compounds, are described.
专利号:US-2007287734-A1 优先权日:2006-06-09 标 题 :Preparation and utility of substituted pyrazole compounds with cannabinoid receptor activity 发明人:GANT THOMAS G; SARSHAR SEPEHR 权利人:AUSPEX PHARMACEUTICALS INC 摘要:The present disclosure is directed to modulators of CB-1 type receptors and pharmaceutically acceptable salts and prodrugs thereof, the chemical synthesis thereof, and the medical use of such compounds for the treatment and/or management of the severity and duration of obesity, metabolic syndrome, dyslipidemia, glucose imbalance, the inability to maintain weight loss, insulin resistance, a cardiovascular disorder, memory loss, drug dependence, a depressive disorder, a panic disorder, an obsessive-compulsive disorder, anxiety, post-traumatic stress syndrome, and any other condition in which it is beneficial to inhibit, inversely agonize or modulate a cannabinoid receptor are described.
专利号:US-2008039473-A1 优先权日:2006-08-08 标题:Preparation and utility of substituted quinazoline compounds with alpha-adrenergic blocking effects 发明人:GANT THOMAS G; SARSHAR SEPEHR 权利人:AUSPEX PHARMACEUTICALS INC 摘要:The present disclosure is directed to modulators of alpha-adrenergic receptors and pharmaceutically acceptable salts and prodrugs thereof, the chemical synthesis thereof, and the use of such compounds for the treatment and/or management of hypertension, cardiac failure, prostatitis, and benign prostatic hyperplasia, and any other condition in which it is beneficial to modulate an alpha-adrenergic receptor.
专利号:US-2008262086-A1 优先权日:2007-04-18 标 题 :Substituted anthranilic acids 发明人:GANT THOMAS G; SARSHAR SEPEHR 权利人:AUSPEX PHARMACEUTICALS INC 摘要:Disclosed herein are substituted anthranilic acids, pharmaceutically acceptable salts and prodrugs thereof, the chemical synthesis thereof, and medical use of such compounds for the treatment and/or management of hypertension, edema associated with congestive heart failure, hepatic disease, renal disease including nephrotic syndrome, or clearance of toxic substances from the body.
专利号:US-2008280886-A1 优先权日:2007-05-08 标题:Substituted ureas 发明人:GANT THOMAS G; SARSHAR SEPEHR 权利人:AUSPEX PHARMACEUTICALS INC 摘要:Disclosed herein are urea-based 5-HT receptor modulators, pharmaceutically acceptable salts and prodrugs thereof, the chemical synthesis thereof, and medical use of such compounds for the treatment and/or management of 5-HT receptor-mediated disorders.
专利号:RU-2145957-C1 优先权日:1993-12-23 标 题:Derivatives of 5-[(2h-pyrrole-2-ylidene)methyl]-2,2'-bi-1h- -pyrrole showing immunomodulating activity, method of their synthesis, pharmaceutical composition based on thereof
[参考文献]: Armisen R, Gaiatas F. Agar[参考文献]: Nakano M, Et Al. Sustained Release Of Sulphamethizole From Agar Beads. J Pharm Pharmacol. 1979 Dec;31(12):869-72. [参考文献]: Patel J, Soni D, Raol G, Et Al. Agar-Agar Bioplastic Synthesis And Its Characterization[参考文献]: 2019. [参考文献]: Celenk Molva, Et Al. Effect Of Sporulation Medium On Wet-Heat Resistance And Structure Of Alicyclobacillus Acidoterrestris Dsm 3922-Type Strain Spores And Modeling Of The Inactivation Kinetics In Apple Juice. Int J Food Microbiol. 2014 Oct 17:189:82-8. [参考文献]: F Heath Damron, Et Al. Genes Required For And Effects Of Alginate Overproduction Induced By Growth Of Pseudomonas Aeruginosa On Pseudomonas Isolation Agar Supplemented With Ammonium Metavanadate. J Bacteriol. 2013 Sep;195(18):4020-36.
合成参考文献
参考文献:10.1016/j.vetmic.2010.01.014 摘要:Foster G, Evans J, Tryland M, Hollamby S, MacArthur I, Gordon E, Harley J, Voigt K. Use of citrate adonitol agar as a selective medium for the isolation of Escherichia fergusonii from a captive reindeer herd. Vet Microbiol. 2010 Aug 26;144(3-4):484–6. doi: 10.1016/j.vetmic.2010.01.014. 参考文献:10.1111/j.1472-765x.2010.02811.x 摘要:Schwaiger K, Hölzel C, Mayer M, Bauer J. Notes on the almost unknown genus Jeotgalicoccus. Lett Appl Microbiol. 2010 Apr;50(4):441–4. doi: 10.1111/j.1472-765x.2010.02811.x. 参考文献:10.1007/bf00425415 摘要:Gupta RS, Kumar HD. Action of mutagenic chemicals on Anacystis nidulans. V. Diethyl sulphate. Arch Mikrobiol. 1970;70(4):313–29. doi: 10.1007/bf00425415. 参考文献:10.1016/j.jbiosc.2009.09.004 摘要:Imanaka H, Tanaka S, Feng B, Imamura K, Nakanishi K. Cultivation characteristics and gene expression profiles of Aspergillus oryzae by membrane-surface liquid culture, shaking-flask culture, and agar-plate culture. Journal of Bioscience and Bioengineering. 2010 Mar;109(3):267–73. doi: 10.1016/j.jbiosc.2009.09.004. 参考文献:10.3390/ijms12063394 摘要:Rossi F, Santoro M, Casalini T, Veglianese P, Masi M, Perale G. Characterization and degradation behavior of agar-carbomer based hydrogels for drug delivery applications: solute effect. Int J Mol Sci. 2011;12(6):3394–408.