专利号:US-6562844-B2 优先权日:1998-01-23 标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation 发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC 权利人:UPJOHN CO 摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.
专利号:CN-1208037-A 优先权日:1994-01-11 标题 :Intermediates for the synthesis of fluoropropylthiazoline derivatives
专利号:US-5721364-A 优先权日:1996-12-13 标题:Process for making 2-amino-4, 6-dialkoxy-1, 3, 5-triazines 发明人:HOGLEN DEAN KENT; SCHWEMLEIN HEINZ PETER; WU HERNG-TAY 权利人:NOVARTIS AG 摘要:A method is provided for making ammelide ethers, such as a 2-amino-4,6-dialkoxy-1,3,5-triazine. A 2-amino-4,6-dihalo-1,3,5-triazine (ADXT) is synthesized in the presence of an aromatic organic solvent, and reaction is effected directly between the (ADXT) synthesis mixture and an alkali metal C.sub.(1-4) alkoxide and C.sub.(1-4) alkanol, including contact through a static mixer. These ammelide ethers are useful as intermediates for making N-phenylsulfonyl-N-triazinylureas, which have herbicidal and growth regulating properties.
参考文献:10.1016/s0003-4509(07)90031-0 摘要:Gibaud S, Astier A. [Organoarsenicals derived from 2-phenyl-[1,3,2]dithiarsolan-4-yl)-methanol (AsIII) with antileukaemic properties: from trypanosomicides to anticancer drugs]. Ann Pharm Fr. 2007 May;65(3):162–8. doi: 10.1016/s0003-4509(07)90031-0.