CAS: 23915-07-3; 1-(Bromomethyl)-2,4-Difluorobenzene

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CAS号56456-47-4 2,4-二氟苯甲醇 | CAS号452-76-6 2,4-二氟甲苯 | CAS号1550-35-2 2,4-二氟苯甲醛 | CAS号31105-93-8 (S)-2-Amino-3-(... | CAS号81228-09-3 2,4-二氟苯乙酸 | CAS号170924-51-3 Benzenemethanet... | CAS号627076-28-2 Hydrazine, [(2,...

2,4-二氟苯甲醛置于甲醇,Sodium Tetrahydroborate,三溴化磷体系中,用 二氯甲烷 用作溶剂,化学反应生成2,4-二氟溴苄
参考文献:N-Benzyl-1H-1,2,3-Triazole-4,5-Dicarboxylate和(N-Benzyl-1H-1,2,3-Triazole-4,5-二基)二甲醇衍生物
标题:N-Benzyl-1H-1,2,3-Triazole-4,5-Dicarboxylate和(N-Benzyl-1H-1,2,3-Triazole-4,5-二基)二甲醇衍生物
摘要:本研究重点合成了各种n-Benzyl-1H-1,2,3-Triazole-4,5-Dicarboxylate和( N-Benzyl-1H-1,2,3-Triazole-4,5-Diyl)在不使用溶剂和催化剂的情况下,在绿色化学条件下制备二甲醇衍生物.还研究了它们对黄嘌呤氧化酶 (Xo) 活性的抑制特性.所有二甲醇和二羧酸衍生物均表现出显着的抑制活性,Ic 50值范围为 0.71 至 2.25 μm.特别是,(1-(3-溴苄基)-1 ħ 1,2,3-三唑-4,5-二基)二甲醇(5C)和二甲基1-(4-氯苄基)-1 ħ 1,2,3--Triazole-4,5-Dicarboxylate ( 6 G) 化合物被发现是最有希望的 Xo 酶抑制衍生物,Ic 50值分别为 0.71 和 0.73 μm.此外,双对接程序是在原子水平上评估复合抑制模式及其与蛋白质 (Xo) 的相互作用.令人惊讶的是,对接结果显示出与
Doi:10.1016/j.Bioorg.2021.104654

专利信息

专利号:US-6867202-B1
优先权日:1997-06-25
标 题 :Treatment of insulin resistance
发明人：CARPINO PHILIP ALBERT; CHIU CHARLES KWOK-FUNG; PAN LYDIA CODETTA; LEFKER BRUCE ALLEN; TREADWAY JUDITH LEE; ZAWISTOSKI MICHAEL PAUL
权利人:PFIZER
摘要:This invention is directed to methods of treating insulin resistance in a mammal which comprise administering an effective amount of a compound of formula I, n n nwhere the variables are defined in the specification, or the stereoisomeric mixtures, diastereomerically enriched, diastereomerically pure, enantiomerically enriched or enantiomerically pure isomers, or the pharmaceutically acceptable salts and prodrugs thereof to said mammal. The compounds of formula I are growth hormone secretagogues and as such are useful for increasing the level of endogenous growth hormone. In another aspect this invention provides certain intermediates which are useful in the synthesis of the foregoing compounds and certain processes useful for the synthesis of said intermediates and th compounds of formula I. This invention is further directed to methods comprising administering to a human or other animal a combination of a functional somatostatin antagonist such as an alpha-2 adrenergic agonist and a compound of formula I.

专利号:US-7468375-B2
优先权日:2004-04-26
标题:Inhibitors of the HIV integrase enzyme
发明人：DRESS KLAUS RUPRECHT; HU QIYUE; JOHNSON TED WILLIAM; PLEWE MICHAEL BRUNO; TANIS STEVEN PAUL; WANG HAI; YANG ANLE; YIN CHUNFENG; ZHANG JUNHU
权利人:PFIZER
摘要:The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as modulators or inhibitors of the human immunodeficiency virus (“HIVâ€?) integrase enzyme.

专利号:US-9018203-B2
优先权日:2012-04-18
标题 :Pharmaceutical composition of salicylanilide-derived small molecules and preparation and application thereof
发明人：CHANG DEH-MING; HUANG HSU-SHAN; CHEN CHUN-LIANG; LEE CHIA-CHUNG
权利人:CHANG DEH-MING; HUANG HSU-SHAN; CHEN CHUN-LIANG; LEE CHIA-CHUNG; NAT DEFENSE MEDICAL CT
摘要:The present invention provides a pharmaceutical composition of salicylanilide-derived small molecules include:n (a) a compound which structure is selected from formula I or formula II: nn n n n n n n n n n n n (b) a pharmaceutically acceptable salt and excipient. The present invention also provides the synthesis method of the pharmaceutical composition and the application thereof.

专利号:PL-240596-B1
优先权日:2018-12-06
标 题 :Synthesis of pyridin-2-yl-vinylpyridinyl (PvP) derivatives

专利号:US-6861523-B2
优先权日:2002-02-08
标 题 :1,3,5- trisubstituted-1,3,5-triazine-2,4,6-trione compounds and libraries
发明人：YU YONGPING; OSTRESH JOHN M; HOUGHTEN RICHARD A
权利人:TORREY PINES INST
摘要:The solid-phase synthesis of individual 1,3-disubstituted and 1,3,5-trisubstituted-1,3,5-triazine-2,4,6-triones and libraries thereof from a resin is described. Reaction of resin-bound amino acids with isocyanates yields resin-bound ureas, which further react with chlorocarbonyl isocyanate to selectively afford the resin-bound 1,3-disubstituted-1,3,5-triazine-2,4,6-triones. Selective alkylation at the N-5 position of the resin-bound 1,3-disubstituted-1,3,5-triazine-2,4,6-triones produces a trisubstituted triazinetrione. The products are cleaved from their solid support and obtained in good yield and purity.

专利号:US-2005113397-A1
优先权日:2002-01-31
标题:Imidazo[1,2-a]pyridine derivative
发明人：TAKEMURA MAKOTO; TAKAHASHI HISASHI; KAWAKAMI KATSUHIRO; TAKESHITA HIROSHI; KIMURA YOUICHI; WATANABE JUN; SUGIMOTO YUICHI; KITAMURA AKIHIRO; NAKAJIMA RYOHEI; KANAI KAZUO; FUJISAWA TETSUNORI
摘要:A compound reprsented by the following formula (I), its salts or nsolvates thereof capable of specifically or selectively expressig an antifungal activity in a broad spectrum based on the novel mechanism thereof of 1,6-β-glucan synthesis inhibition, and an antifungal agent containing any of them.