CAS: 4285-42-1; Methyl(Phenyl)Carbamic Chloride

该化合物是一种多用途试剂,广泛用于有机合成,特别是用于制备氨基甲酸酯和尿素,该化合物是将N-甲基-N-苯基氯丙胺基组引入目标分子的有效电极,它与氨胺和酒精等核分裂物具有高度的共性,能够有效地衍生药物和农用化学应用.氯化物与其他辛醇剂相比,增强了稳定性和处理能力,同时保持了反应的选择性.在无水条件下,它通常用于化并循环功能,建议在冷干环境中适当储存以防止水解.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

ethyl N-methyl-N-phenylcarbamate phosgene N-methylaniline 1,1'-carbonyl-bis-pyridinium; dichlorideN'-(2-hydroxy-phenyl)-N-methyl-N-phenyl-ureaN'-(2-hydroxy-phenyl)-N-methyl-N-phenyl-urea 2-Benzoxazolinone N-methyl-anilide)dibenzofuran-2-carboxylic acid-(N-methyl-anilide) N-methyl-[1]naphthanilideN-methyl-[1]naphthanilide

合成工艺路线路线简述

    N-甲基-N-苯基乌拉坦置于三氯氧磷体系中,化学反应生成 N-甲基-N-苯基氨基甲酰氯
    参考文献:Schmidt,O.,Chemische Berichte,1903,Vol. 36,P. 2476
    标题:Schmidt,O.,Chemische Berichte,1903,Vol. 36,P. 2476

    海关参考信息

    专利信息


    专利号:WO-9700244-A1
    优先权日:1995-06-19
    标题 :Process for parallel synthesis of a non-peptide library
    发明人:FRITZ JAMES E; KALDOR STEPHEN W
    权利人:LILLY CO ELI; FRITZ JAMES E; KALDOR STEPHEN W
    摘要:A process for the sequential preparation of a library of compounds having pharmaceutical usage. The process involves the sequential mixing of solution phase reagents, followed by scavenging of excess unreacted reagents with solid phase scavenging agents. The process is highly iterative and applicable for producing various ureas, thiureas, amides, carbonates and tertiary amines.

    专利号:US-2004028702-A1
    优先权日:2002-07-26
    标 题:Muramic acid derivative compounds
    发明人:MALETIC MILANA M; LEEMAN AARON H; SANTORELLI GINA M; WADDELL SHERMAN T
    摘要:The present invention pertains to the combinatorial synthesis of antibacterial agents that inhibit the Mur-pathway enzymes involved in bacterial cell wall assembly. The method uses p-alkoxybenzylidene as the linker for the attachment of a derivatized muramic acid to the polymeric resin support. This intermediate becomes the starting point for the combinatorial synthesis, which in conjunction with split-pooling techniques allows rapid synthesis of diverse analogues for high-throughput screening (HTS). The invention is further directed to the libraries of these finished compounds that vary at the peptide, N-acyl and anomeric UDP positions.

    专利号:CN-112094250-A
    优先权日:2020-09-28
    标题 :A kind of method for continuous synthesis of thiazide

    专利号:US-7807709-B2
    优先权日:2005-03-23
    标题 :Organic compounds
    发明人:EHRHARDT CLAUS; IRIE OSAMU; LORTHIOIS EDWIGE LILIANE; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; SELLNER HOLGER
    权利人:NOVARTIS AG
    摘要:The invention relates to the use of (3,4-di-, 3,3,4-tri, 3,4,4-tri- or 3,3,4,4-tetra-)substituted pyrrolidine compounds for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; compounds that are part of a subclass of these substituted pyrrolidine compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; new compounds that are part of a subclass of these substituted pyrrolidine compounds; pharmaceutical formulations comprising said substituted pyrrolidine compounds, and/or a method of treatment comprising administering said substituted pyrrolidine compounds, a method for the manufacture especially of said new substituted pyrrolidine compounds, as well as novel intermediates, starting materials and/or partial steps for their synthesis.
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    合成参考文献


    摘要:Silva, V. L. M.; Pinto, D. C. G. A.; Santos, C. M. M.; Rocha, D. H. A., Science of Synthesis Knowledge Updates, (2022) 3, 210.
    摘要:Aitken, R. A.; Boubalouta, Y., Science of Synthesis Knowledge Updates, (2013) 4, 156.
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