CAS: 473927-63-8; (Z)-Ethyl 2-Chloro-2-(2-(4-Methoxyphenyl)Hydrazono)Acetate

上下游产品

4-methoxy-aniline ethyl 2-chloro-3-oxo-butyrate sodium acetate chloroacetic acid ethyl ester4,5,6,7-tetrahydro-1-(4-methoxyphenyl)-6-(4-nitrophenyl)-7-oxo- 1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester 1-(4-methoxy-phenyl)-6-(4-iodo-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester ethyl 4-acetyl-1-(4-methoxyphenyl)-5-methyl-1H-pyrazole-3-carboxylate 1-(4-methoxy-phenyl)-7-oxo-6-[4-(2-oxo-piperidin-1-yl)-phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester

甲氧苯胺,氯乙酸乙酯置于硫酸,Sodium Bromide,Sodium Nitrite,Sodium Acetate体系中,用 乙醇 作为反应溶剂,化学反应 2.33H,以92.3%的收率获得产物(2Z)-氯[(4-甲氧基苯基)亚肼基]乙酸乙酯
参考文献:(Z)-[(4-甲氧基苯基)亚肼基]氯乙酸乙酯的制备方法
标题:(Z)-[(4-甲氧基苯基)亚肼基]氯乙酸乙酯的制备方法
摘要:本发明公开了一种阿哌沙班中间体(Z)‑[(4‑甲氧基苯基)亚肼基]氯乙酸乙酯的制备方法,本方法以对甲氧基苯胺和氯乙酸乙酯为起始原料,制备得到本品.使用本合成方法制备的产品纯度高,质量稳定,收率高,并且合成工艺简单,反应条件温和,反应操作简便,绿色环保,能够满足产品工业化生产的需求.

专利信息

专利号:US-7153960-B2
优先权日:2001-12-10
标 题:Synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones
发明人：ZHOU JIACHENG; OH LYNETTE M; MA PHILIP; LI HUI-YIN; CONFALONE PASQUALE
权利人:BRISTOL MYERS SQUIBB CO
摘要:A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described. n nThese compounds are useful as factor Xa inhibitors.

专利号:US-2003181466-A1
优先权日:2001-12-10
标 题:Synthesis of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones

专利号:US-2005245566-A1
优先权日:2001-12-10
标 题:Synthesis of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones

专利号:US-2007027186-A1
优先权日:2001-12-10
标 题:Synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones

专利号:EP-1467984-A4
优先权日:2001-12-10
标题:SYNTHESIS OF 4,5-DIHYDROPYRAZOLO (3,4-C) PYRID-2-ONES

专利号:AU-2002346624-A1
优先权日:2001-12-10
标 题:Synthesis of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones