CAS: 71251-02-0; N,N'-(1,1'-(Decane-1,10-Diyl)Bis(Pyridin-1(1H)-Yl-4(1H)-Ylidene))Bis(Octan-1-Amine)

该化合物是一种以其强大的抗微生物特性而得到广泛承认的丙基表面活性剂和二重衍生物,它展示了针对细菌,真菌和包装病毒的广泛频谱活动,使其成为抗菌剂和消毒剂制剂中的宝贵制剂. 屋特尼丁的行动机制包括破坏微生物细胞膜,导致快速的细菌杀菌和杀菌效应. 其低毒性和强效残留活动增强了其适用于包括创伤护理,皮肤抗菌素和肌肉消毒等专题应用的适宜性. 与某些传统的抗菌剂不同,八丁基在有机材料存在的情况下保持了功效,并展示了抗药性发展的最小性能. 这些特征表明它作为临床和卫生应用的可靠选择.

结构式图片

上下游产品

°Ctenidine dihydr°Chloride 4-aminopyridine °Ctanal

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    海关参考信息

    专利信息


    专利号:WO-2021013997-A1
    优先权日:2019-07-25
    标 题:Process for the synthesis of n-alkyl-4-pyridinamines

    专利号:US-11229591-B2
    优先权日:2018-12-21
    标 题:Methods for synthesizing zinc-lysine-chloride complex
    发明人:JARACZ STANISLAV; PAN LONG
    权利人:COLGATE PALMOLIVE CO
    摘要:Disclosed herein are improved methods for the synthesis of zinc-amino acid-halide complexes via reaction of zinc oxide and amino acid hydrochloride with a slight molar excess of amino acid hydrohalide, as well as oral care compositions comprising said complexes made according to said method.

    专利号:US-11117906-B2
    优先权日:2018-12-21
    标题:Methods for synthesizing zinc-lysine-chloride complex
    发明人:HAO ZHIGANG; CHENG CHI-YUAN; BRINZARI TATIANA; PAN LONG; SUBRAMANYAM RAVI; EVANS LAUREN; LEITE SERGIO
    权利人:COLGATE PALMOLIVE CO
    摘要:Disclosed herein are improved methods for the synthesis of zinc-amino acid-halide complexes via reaction of zinc oxide and amino acid hydrochloride in a solvent comprising a polyol, as well as oral care compositions comprising said complexes made according to said method.

    专利号:WO-2024083930-A1
    优先权日:2022-10-18
    标 题:Topically applied preparation for improving skin condition
    发明人:HEUER ANDREA; HÜPEDEN JENNIFER
    权利人:BEIERSDORF AG
    摘要:The invention relates to a topically applied preparation comprising a combination of substances including antimicrobial peptides (AMP), in particular cyclic peptide compounds based on the synthesis of thiazolidine and oxazolidine components, and skin-soothing substances such as menthoxypropanediol, substances to strengthen the skin barrier such as omega-6 fatty acids, and/or flavonoids such as licochalcone, which act synergetically and selectively against pathogenic bacteria, such as S. aureus and C. acnes , however not against skin-commensal bacteria, such as S. epidermidis . The preparations can be used advantageously for the treatment of acne or atopic dermatitis and to care for skin that has been damaged by acne or atopic dermatitis.

    专利号:US-11091502-B2
    优先权日:2018-12-21
    标 题:Methods for synthesizing zinc-lysine-chloride complex
    发明人:HAO ZHIGANG; CHENG CHI-YUAN; BRINZARI TATIANA; PAN LONG; SUBRAMANYAM RAVI
    权利人:COLGATE PALMOLIVE CO
    摘要:Disclosed herein are improved methods for the synthesis of zinc-amino acid-halide complexes via reaction of zinc halide and amino acid free base in a solvent comprising a polyol, as well as oral care compositions comprising said complexes made according to said method.

    专利号:WO-2024083413-A1
    优先权日:2022-10-18
    标题:Topically applied preparation with antimicrobial peptides
    发明人:HEUER ANDREA; HÜPEDEN JENNIFER
    权利人:BEIERDSORF AG
    摘要:The invention relates to a topically applied preparation comprising a combination of substances including antimicrobial peptides (AMP), in particular cyclic peptide compounds based on the synthesis of thiazolidine and oxazolidine components, and skin-soothing substances such as menthoxypropanediol, substances to strengthen the skin barrier such as omega-6 fatty acids, and/or flavonoids such as licochalcone, which act synergetically and selectively against pathogenic bacteria, such as S. aureus and C. acnes, however not against skin-commensal bacteria, such as S. epidermidis. The preparations can be used advantageously for the treatment of acne or atopic dermatitis and to care for skin that has been damaged by acne or atopic dermatitis.
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    主要参考文献


    1: Assadian O. Octenidine dihydrochloride: chemical characteristics and antimicrobial properties. J Wound Care. 2016 Mar;25(3 Suppl):S3-6. doi: 10.12968/jowc.2016.25.Sup3.S3. 23(5):244-58. doi: 10.1159/000314699. Epub 2010 May 18. 75(12):3576-3581. doi: 10.1093/jac/dkaa346. 30(5):613-614. doi: 10.1684/ejd.2020.3856.
    5: Yakuschenko IK, Pozdeeva NN, Mumyatova VA, Terentiev AA, Gadomsky SY. Iso- octenidine: Promising Octenidine Analogue with Improved Solubility. Curr Org Synth. 2020 Dec 30. doi: 10.2174/1570179417666201231104453. Epub ahead of print. 100(3):e23-e29. doi: 10.1016/j.jhin.2018.03.037. Epub 2018 Mar 31. 28(2):106-111. doi: 10.1080/08982104.2016.1275678. Epub 2017 Jan 18. 69(5):427-429. German. doi: 10.1007/s00105-018-4139-0. 25(9):1154.e1-1154.e7. doi: 10.1016/j.cmi.2018.12.036. Epub 2019 Jan 6. 10 Suppl 1(Suppl 1):9-14. doi: 10.1111/iwj.12175.

    合成参考文献


    摘要:S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (2021) DOI:10.1021/acsenvironau.1c00008. List downloaded from
    参考文献:10.1007/bf03365333
    摘要:Kreutzkamp B. [Therapy of atopic eczema in the new light. When the skin barrier is not firm]. MMW Fortschr Med. 2008 Feb 14;150(7):12–4. doi: 10.1007/bf03365333.
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