CAS: 7724-76-7; (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(6-((3-Methylbut-2-En-1-yl)Amino)-9H-Purin-9-yl)Tetrahydrofuran-3,4-Diol

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N(6)-(Delta(2)-异戊烯基)腺苷 5'-单磷酸酯置于乙酸铵,Alkaline Phosphatase体系中,用 水 作为反应溶剂,化学反应 1.5H,反应生成 利波腺苷
参考文献:Efficiency Of Different Methods Of Extraction And Purification Of Cytokinins
标题:Efficiency Of Different Methods Of Extraction And Purification Of Cytokinins
摘要:The Increasing Use Of Advanced Methods,Such As Mass Spectrometry,For The Determination Of Cytokinins Has Raised Special Requirements For The Extraction And Purification Of This Class Of Plant Hormones. Extraction Of Arabidopsis Thaliana Plants With Three Different Solvents,[80% (V/v) Meoh,Bieleski'S Mcf-7,And Modified Bieleski'S] Provided Similar Yields Of Most Analyzed Cytokinins Determined By High-Performance Liquid Chromatography-Tandem Mass Spectrometry (HPLC/ms/ms). However,The Extraction With A Modified Bieleski'S Solvent (Meoh-Hco2H-H2O [15:1:4,V/v/v]) Gave The Highest Responses Of Deuterated Cytokinins (Used As Test Compounds) In Plant Extracts As Compared To The Responses Of Pure Deuterated Standards (Relative Internal Standard Response,Risr). Purification Of Cytokinins Using Oasis Mcx Sorbent With Reversed-Phase And Cation-Exchange Characteristics,In Comparison To The Deae Sephadex Rp-C-18 Method,Provided Higher Levels Of Zeatin Riboside Monophosphate And Similar Levels Of Cytokinin Bases,Ribosides And Glucosides. Using This Method The Content Of Uv-Absorbing Contaminates Was Decreased By About 90% And The Risr Values Of All Tested Cytokinin Standards But Riboside Monophosphates Were Increased About Two-Fold. The Former Method Provided Preparations More Suitable For HPLC/ms/ms Analysis With Respect To Simplicity And Sample Purity. (C) 2006 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Phytochem.2006.03.010

专利信息

专利号:US-2012177593-A1
优先权日:2009-07-20
标 题 :Synthesis of dendrimer conjugates
发明人：BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH
权利人:BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH; UNIV MICHIGAN
摘要:The present invention relates to novel methods of synthesis of therapeutic and diagnostic dendrimers. In particular, the present invention is directed to novel dendrimer conjugates, novel methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer, inflammatory disease) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer conjugates of the present invention may further comprise at least two different components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy. Furthermore, the novel synthesis methods of certain embodiments of the present invention provide significant advantages with regard to total reaction time and simplicity.

专利号:US-8734846-B2
优先权日:2008-06-16
标 题 :Methods for the preparation of targeting agent functionalized diblock copolymers for use in fabrication of therapeutic targeted nanoparticles
发明人：ALI MIR M; HRKACH JEFF; ZALE STEPHEN E; ALVAREZ DE CIENFUEGOS LUIS
权利人:BIND BIOSCIENCES INC
摘要:This application provides nanoparticles and methods of making nanoparticles using pre-functionalized poly(ethylene glycol)(also referred to as PEG) as a macroinitiator for the synthesis of diblock copolymers. Ring opening polymerization yields the desired poly(ester)-poly (ethylene glycol)-targeting agent polymer that is used to impart targeting capability to therapeutic nanoparticles. This “polymerization fromâ€? approach typically employs precursors of the targeting agent wherein the reactivity of functional groups of the targeting agent is masked using protecting groups. Also described is a “coupling toâ€? that utilized the poly(ethylene glycol)-targeting agent conjugate where the targeting agent remains in its native un-protected form. This method uses “orthogonalâ€? chemistry that exhibit no cross reactivity towards functional groups typically found within targeting agents of interest.

专利号:US-2013035307-A1
优先权日:2010-01-26
标 题:Methods for treating or preventing the spread of cancer using semi-synthetic glycosaminoglycosan ethers
发明人：PRESTWICH GLENN D; KENNEDY THOMAS P
权利人:UNIV UTAH RES FOUND; PRESTWICH GLENN D; KENNEDY THOMAS P
摘要:Described herein are methods for the treatment and prevention of tumor metastasis using alkylated and fluoroalkylated semi-synthetic glycosaminoglycan ethers (“SAGEsâ€?). The synthesis of sulfated alkylated and fluoroalkylated SAGEs is also described.

专利号:US-2008214827-A1
优先权日:2004-02-03
标 题:Synthesis of Cyanoimino-Benzoimidazoles
发明人：GOEHRING R RICHARD; WHITEHEAD JOHN; SHAO BIN
权利人:EURO CELTIQUE SA
摘要:Disclosed in certain embodiments is a process for synthesizing a compound of formula (V) and salts thereof.

专利号:US-9220714-B2
优先权日:2006-03-16
标 题 :Nitrofuran compounds for the treatment of cancer and angiogenesis
发明人：SAULNIER SHOLLER GISELLE L; SWAMY NARASIMHA; KALKUNTE STAYAN; SINGH RAKESH K; BRARD LAURENT; KIM KYU KWANG
权利人:WOMEN AND INFANTS HOSPITAL OF RHODE ISLAND; UNIV BROWN; WOMEN AND INFANTS HOSPITAL RHODE ISLAND
摘要:The invention is directed to the synthesis and use of nitrofuran compounds, especially Nifurtimox, as medicaments to treat cancer, especially neuroblastoma, and to inhibit angiogenesis. The invention also provides compositions, unit dosage forms, and kits comprising the compounds.

专利号:US-9790531-B2
优先权日:2012-08-14
标 题 :Enzymes and polymerases for the synthesis of RNA
发明人：WANG YUXUN; RAMAKRISHNAN DIVAKAR; DE FOUGEROLLES ANTONIN; WHORISKEY SUSAN
权利人:MODERNATX INC
摘要:The invention relates to compositions and methods for the design, evolution, preparation, and/or manufacture of enzymes for use with polynucleotides, primary transcripts and mmRNA molecules.