专利号:US-2013338369-A1 优先权日:2011-03-07 标 题 :Process for the Synthesis of Aminobiphenylene 发明人:HEINRICH MARKUS; PRATSCH GERALD 权利人:HEINRICH MARKUS; PRATSCH GERALD; BASF SE 摘要:The present invention relates to a process for the synthesis of 2-aminobiphenylene and derivatives thereof by reacting a benzene diazonium salt with an aniline compound under basic reaction conditions.
专利号:US-8058477-B2 优先权日:2006-03-21 标 题 :Process for the synthesis of arylamines from the reaction of an aromatic compound with ammonia or a metal amide 发明人:HARTWIG JOHN F; SHEN QILONG 权利人:HARTWIG JOHN F; SHEN QILONG; UNIV YALE 摘要:A catalytic process for the synthesis of aromatic primary amines, reagent compositions for effecting the process, and transition metal complexes useful in the process, are provided.
专利号:US-11744150-B2 优先权日:2012-01-20 标 题:Synthesis of aza-acenes as novel n-type materials for organic electronics 发明人:THOMPSON MARK E; SOMMER JONATHAN R; BARTYNSKI ANDREW 权利人:UNIV SOUTHERN CALIFORNIA 摘要:Acenes, such as aza-acenes are attractive materials for organic semiconductors, specifically for n-type materials. There are disclosed new derivatives of acenes that are fabricated using novel synthesis. For example, the disclosed fabrication strategies have allowed for the first time new aza-tetracene and aza-pentacene derivatives. The HOMO and LUMO energy levels of these materials are tunable through appropriate substitution and as predicted, deepened. There are also disclosed organic photosensitive devices comprising at least one aza-acene such as aza-tetracene and aza-pentacene.
专利号:WO-9946236-A1 优先权日:1998-03-12 标题 :Modulators of protein tyrosine phosphatases (ptpases) 发明人:RICHTER LUTZ STEFAN; ANDERSEN HENRIK SUNE; VAGNER JOSEF; JEPPESEN CLAUS BEKKER; MOELLER NIELS PETER HUNDAHL; BRANNER SVEN; SU JING; BAKIR FARID; JUDGE LUKE MILBURN 权利人:NOVO NORDISK AS; ONTOGEN CORP 摘要:The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPases) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.
专利号:US-2024309003-A1 优先权日:2021-05-04 标题 :Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use 发明人:HOUZE JONATHAN B; BOS MAXENCE; MANCUSO JOHN; FRANZONI IVAN; PANDYA BHAUMIK; KAPLAN ALAN 权利人:VIGIL NEUROSCIENCE INC 摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2â€?). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.
专利号:US-6180830-B1 优先权日:1995-11-08 标题 :Method for preparing a bimetallic ruthenium/tin catalyst and a process for the synthesis of aldehydes 发明人:JACQUOT ROLAND 权利人:RHODIA CHIMIE SA 摘要:The present invention relates to a new process for the preparation of a bimetallic ruthenium/tin catalyst. The process for the preparation of a bimetallic ruthenium/tin catalyst according to the invention is characterised by the fact that it consists in carrying out the reduction of a ruthenium complex having an electrovalency of -4 and a coordination number of 6, the ligands being either a halogen atom or an anion or a tin halide. The catalyst is further employed for the preparation of aldehydes by reduction, in the vapor phase, of carboxylic acids, esters and anhydrides.
1: Madawala H, Sabaragamuwe SG, Elangovan S, Kim J. In Situ Measuring Partition Coefficient at Intact Nanoemulsions: A New Application of Single-Entity Electrochemistry. Anal Chem. 2021 Jan 19;93(2):1154-1160. doi: 10.1021/acs.analchem.0c04205. Epub 2020 Dec 8. 1139:129-137. doi: 10.1016/j.aca.2020.09.053. Epub 2020 Sep 29. 63(8):4349-4369. doi: 10.1021/acs.jmedchem.0c00297. Epub 2020 Apr 9. 26(5):1064-1073. doi: 10.1002/chem.201903279. Epub 2020 Jan 16. 102(2):580-589. doi: 10.5740/jaoacint.18-0165. Epub 2018 Oct 10. 43(1):25-35. doi: 10.1093/jat/bky045. 7: Takekuma Y, Ishizaka H, Sumi M, Sato Y, Sugawara M. Difference in the Dissolution Behaviors of Tablets Containing Polyvinylpolypyrrolidone (PVPP) Depending on Pharmaceutical Formulation After Storage Under High Temperature and Humid Conditions. J Pharm Pharm Sci. 2016 Oct-Dec;19(4):511-519. doi: 10.18433/J3HW3Q. 37(10):1945-52. doi: 10.1007/s10529-015-1876-3. Epub 2015 Jul 5. 17(6):1597-600. doi: 10.1021/acs.orglett.5b00502. Epub 2015 Mar 11. 4(12):4301-4307. doi: 10.1039/C4CY00764F.
合成参考文献
参考文献:10.1016/j.chroma.2011.06.072 摘要:Schubert J, Kappenstein O, Luch A, Schulz TG. Analysis of primary aromatic amines in the mainstream waterpipe smoke using liquid chromatography-electrospray ionization tandem mass spectrometry. J Chromatogr A. 2011 Aug 19;1218(33):5628–37. doi: 10.1016/j.chroma.2011.06.072. 参考文献:10.1107/s1600536811008890 摘要:Gainsford GJ, Ashraf M, Kay AJ. 2-{[(Biphenyl-2-yl)diazen-yl]methyl-idene}-1,3,3-trimethyl-indoline. Acta Crystallogr Sect E Struct Rep Online. 2011 Apr 01;67(Pt 4):o893.