CAS: 138-52-3; (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(2-(Hydroxymethyl)Phenoxy)Tetrahydro-2H-Pyran-3,4,5-Triol

上下游产品

helicin acetate 2-[[[(1-hydroxy-6-oxo-2-cyclohexen-1-yl)carbonyl]hydroxy]methyl]phenyl-β-D-glucopyranoside 2-methyl-benzyl alcohol Sucrose o-tolyl-β-D-glucopyranosideo-tolyl-β-D-glucopyranoside Penta-O-(isopropoxycarbonyl)salicin (1R,2R)-trans-1,2-cyclohexanediol-1-O-β-D-glucopyranoside (1S,2S)-trans-1,2-cyclohexanediol-1-O-β-D-glucopyranoside

Fragilin置于sodium Methylate体系中,用 甲醇 用作溶剂,化学反应 2.0H,以99%的收率获得水杨苷
参考文献:利用选择性脱乙酰基和乙酰基团迁移合成杨柳科乙酰水杨素.
标题:利用选择性脱乙酰基和乙酰基团迁移合成杨柳科乙酰水杨素.
摘要:在目前的工作中,已报道了许多水杨科物种中天然存在的乙酰化水杨素的合成.描述了由过乙酰化的溴水杨素以选择性酸催化的脱乙酰基作用和一锅式亲核取代溴为关键步骤制备2-O-乙酰水杨素,2-O-乙酰氯水杨素和2-O-乙酰乙基水杨素的方法.碱催化的o-2->o-6乙酰基迁移得到了6-O-乙酰水杨酸衍生物,收率很高.因此,报道了使用乙酰基迁移的第一个6-O-乙酰水杨素(fragilin)合成以及6-O-乙酰氯水杨素和6-O-乙酰乙基水杨素的合成.Naome催化的乙酰化糖苷的脱乙酰作用产生了最近从alangium Chinense报道的水杨素,氯水杨素和乙基水杨素.
Doi:10.1021/acs.Jnatprod.9B00570

专利信息

专利号:US-5116741-A
优先权日:1988-04-12
标题 :Biosynthetic uses of thermostable proteases
发明人：BRYAN PHILIP N; PANTOLIANO MICHAEL W; ROLLENCE MICHELE L; WONG CHI H
权利人:GENEX CORP
摘要:The invention relates to the novel use of mutants of subtilisin in organic syntheses reactions in non-native environments. Especially the invention relates to methods for the use of mutant subtilisins in organic solvents for the catalysis of reactions involving ester formation and cleavage, including acylations and deacylations, and amidations and deamidations. The methods provide novel strategies which are useful in the synthesis of deoxynucleosides, dideoxynucleosides, peptides, sugars and the like.

专利号:US-2024287041-A1
优先权日:2021-05-20
标题 :Methods of synthesis of heteroaryl derivatives of triazolyl acrylamides and crystalline forms
发明人：BALOGLU ERKAN; AUSTAD BRIAN C; ROE DAVID G; KEDUC ANDREW; GOTTSCHLING STEPHEN EDMUND; HECKER EVAN
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The present invention relates to a method of preparing a compound represented by structural formula (VII), comprising reacting a compound represented by structural formula (II), with a compound represented by structural formula (III), in a solvent, in the presence of a Pd catalyst and one or more inorganic bases under conditions suitable to prepare a compound represented by structural formula (VII): The values and example values of the variables in structural formulas (VII), (II), and (III) are defined herein. The present invention also relates to crystalline Forms I and II of the compound represented by Structural Formula (VII), the use of the crystalline Forms in treating disease or disorders associated with CRM1 and method of preparing the crystalline Forms.

专利号:US-6444460-B1
优先权日:1998-08-19
标 题:Microbial production of actinol
发明人：SHIMIZU SAKAYU; WADA MASARU
权利人:ROCHE VITAMINS INC
摘要:A process for making (4R, 6R)-4-hydroxy-2,2,6-trimethylcyclohexanone by contacting (6R)-2,2,6-trimethylcyclohexanedione with a microorganism which is selected from microorganisms of the genera Cellulomonas, Corynebacterium, Planococcus and Arthrobacter and which is capable of the selective asymmetric reduction of (6R)-2,2,6-trimethylcyclohexanedione to (4R, 6R)-4-hydroxy-2,2,6-trimethylcyclohexanone, and recovering the resulting (4R, 6R)-4-hydroxy-2,2,6-trimethylcyclohexanone from the reaction mixture. The selective asymmetric reduction can be effected in the presence of a co-factor, such as, nicotinamide adenine dinucleotide (NAD), nicotinamide adenine dinucleotide phosphate (NADP), or said co-factor with glucose and glucose dehydrogenase (GDH), and/or in the presence of a surfactant. The product is useful for the synthesis of carotenoids, such as, zeaxanthin.

专利号:US-4275163-A
优先权日:1978-11-20
标题:Cellulase-producing microorganism
发明人：GALLO BENEDICT J
权利人:US ARMY
摘要:A process and a microorganism for synthesizing cellulase enzymes are described. The microorganism is a mutant strain of an Ascomycete fungus capable of synthesizing cellulases. The synthesis of cellulases by the mutant is nonrepressed by glycerol, repressed by glucose but not subject to postrepression lag, and inducible to high levels by lactose. Furthermore, the combination of lactose with xylose elicits maximum cellulase synthesis by the mutant.

专利号:AU-2022276509-A1
优先权日:2021-05-20
标题:Methods of synthesis of heteroaryl derivatives of triazolyl acrylamides and crystalline forms

专利号:US-9994558-B2
优先权日:2013-09-20
标题 :Multicyclic compounds and methods of using same
发明人：BALOGLU ERKAN; SHACHAM SHARON; SENAPEDIS WILLIAM; MCCAULEY DILARA; LANDESMAN YOSEF; GOLAN GALI; KALID ORI; SHECHTER SHARON
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to compounds represented by Structural Formula I: or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders (e.g., PAK-mediated, for example, PAK4-mediated, diseases and disorders).