CAS: 1423-60-5; 3-Butyn-2-One

上下游产品

2-methoxy-but-1-en-3-yne but-3-yn-2-ol meso/d,l-3,4-dimethyl-1,5-hexadiyne-3,4-diol 4-trimethylsilyl-3-butyn-2-one 3-piperidino-but-2-enal hepta-2,5-diene2-acetylbicyclo2.2.1hepta-2,5-diene 1-acetyl-1,4-cyclohexadiene 1-(6-methyl-cyclohexa-1,4-dienyl)-ethanone

3-丁炔-2-醇置于chromium(Vi) Oxide,硫酸体系中,用 水 用作溶剂,化学反应 4.5H,反应生成3-丁炔-2-酮
参考文献:1-(2-恶唑烷酮-3-基)-3-甲硅烷氧基-1,3-丁二烯的外消旋和不对称diels-Alder反应.
标题:1-(2-恶唑烷酮-3-基)-3-甲硅烷氧基-1,3-丁二烯的外消旋和不对称diels-Alder反应.
摘要:从容易获得的起始原料制备非手性和手性的1-(2-恶唑烷酮-3-基)-3-甲硅烷氧基-1,3-丁二烯.虽然比母体1-氨基-3-甲硅烷氧基二烯更稳定,但1-(2-恶唑烷酮-3-基)-3-甲硅烷氧基-1,3-丁二烯在狄尔斯-阿尔德反应中仍然具有很高的反应性,比1,3-二烷氧基-1,3-丁二烯(例如,Danishefsky的二烯).检查了具有几种不同的双亲性的非手性和手性二烯的环加成.反应以高产率进行,具有中等至高的内选择性.手性二烯在与α-取代的丙烯醛,马来酸酐和n-苯基马来酰亚胺的环加成中表现出优异的面部选择性.在环加合物还原和水解后,获得的ee范围为22%至> 98%的取代的环己酮.
Doi:10.1021/jo005619Y

专利信息

专利号:US-3793148-A
优先权日:1972-07-24
标题:Microbiological reduction of 1,3,-dioxo-2-alkylcycloalkanes
发明人：LANZILOTTA R
权利人:SYNTEX CORP
摘要:An improved method of microbiologically reducing a 1,3-dioxo-2alkylcycloalkane using members of a group of compounds which increase the production of the 1 Beta -hydroxy-2 Beta -alkyl-3oxocycloalkane product. The products are useful as intermediates in the total synthesis of useful steroid compounds. Alkyl alcohol and acrylonitrile are illustrated as representative of the useful group of compounds.

专利号:US-4973674-A
优先权日:1987-04-14
标 题:Chiral synthesis of anthracyclines from substituted anthraquinones
发明人：BRASCA MARIA G; PENCO SERGIO
权利人:ERBA CARLO SPA
摘要:Anthracycline glycosides of formula (I): ##STR1## wherein R 1 and R 2 are independently selected from hydrogen, methyl, ethyl or methoxy and pharmaceutically acceptable acid addition salts thereof, which are useful in treatment of human cancer, are prepared by a stereospecific condensation of a derivative of daunosamine of general formula (II): ##STR2## wherein R 3 is an alkyl, perfluoroalkyl or aryl group and R 4 , R 5 , R 6 and R 7 are independently selected from alkyl, aryl or aralkyl having up to ten carbon atoms, with a quinone quinizarine epoxide of general formula (III) ##STR3## and conversion of the product obtained to the anthracycline glycoside of formula (I) or salt thereof.

专利号:US-3578724-A
优先权日:1968-03-04
标 题:Migration and isomerization of acetylenes
发明人：HUBERT ANDRE JULES
权利人:UNION CARBIDE CORP
摘要:PROCESS FOR THE MIGRATION OF ACETYLENIC BONDS AND A PROCESS FOR THE ISOMERIZATION OF HYDROCARBONS CONTAINING ACETYLENIC BONDS TO HYDROCARBONS CONTAINING CONJUGATED UNSATURATION, BY CONTACTING A COMPOUND CONTAINING ONE OR TWO ACETYLENIC BONDS WITH POTASSIUM AMIDE ON ALUMINA. THE UNSATURATED COMPOUNDS PRODUCED BY THE PROCESS OF THE INVENTION ARE USEFUL AS ULTRAVIOLET LIGHT ABSORBERS, AS CROSS-LINKING AGENTS FOR POLYOLEFINIC ELASTOMERS, AND AS INTERMEDIATES IN THE SYNTHESIS OF NEW COMPOUNDS.

专利号:US-4623737-A
优先权日:1984-12-07
标 题:Synthesis of precursors of anti-atherosclerotic furochromones
发明人：YAMASHITA AYAKO
权利人:UPJOHN CO
摘要:The present invention provides novel compositions of matter and processes for their preparation. More particularly, the present invention consists of novel chemical intermediates and associated processes for the preparation of khellin and analogues thereof, which have demonstrated antiatherosclerotic activity.

专利号:US-2011166152-A1
优先权日:2008-10-02
标题 :Heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：LECLERC JEAN-PHILIPPE; LI CHUN SING; RAMTOHUL YEEMAN K
权利人:LECLERC JEAN-PHILIPPE; LI CHUN SING; RAMTOHUL YEEMAN K
摘要:Heteroaromatic compounds of structural formula (I) are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD). The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; Type 2 diabetes; insulin resistance; hyperglycemia; Metabolic Syndrome; neurological disease; cancer; and liver steatosis.

专利号:US-4471139-A
优先权日:1982-05-24
标题 :Processes for making 3-methylthiophene-2-carboxaldehyde and intermediates therefor
发明人：ANDREWS GLENN C
权利人:PFIZER
摘要:Processes for preparing isomerically pure 3-methylthiophene-2-carboxaldehyde, an intermediate for synthesis of anthelmintic agents, by reaction of mercaptoacetaldehyde or the dimer, or a polymer thereof, or a dialkylacetal thereof in the presence of a base with (1) methyl vinyl ketone or an alpha- or beta-oxidized derivative of methyl vinyl ketone to form a 3-oxobutylmercaptoacetaldehyde or dialkyl acetal thereof, or an alpha- or beta-substituted derivative thereof which is then converted to 3-methylthiophene-2-carboxaldehyde via appropriate steps including, if necessary, treatment with acid, followed, if necessary, by enamine catalyzed cyclization and, in the case of using methyl vinyl ketone as reactant, a dehydrogenation step; or (2) 3-butyn-2-one to produce a mixture of isomeric 3-oxobut-1-enylmercaptoacetaldehyde or dialkyl acetals thereof which is cyclized to 3-methylthiophene-2-carboxaldehyde. n A further aspect of this invention is an improved process for making dialkyl acetals of 2-mercaptoacetaldehyde which comprises reacting an alkyl vinyl ether with sulfur chloride to produce a bis(2-chloro-2-alkoxy ethyl)disulfide which is then treated with an alcohol to afford a bis(2,2-dialkoxyethyl)disulfide which is reduced under alkaline conditions to 2-mercaptoethyl acetaldehyde alkali metal salt which can be alkylated to a thioether, a valuable intermediate.