CAS: 2131-55-7; 4-Chlorophenylisothiocyanate

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1,3-双(4-氯苯基)硫脲置于乙酸酐体系中,化学反应 1.0H,反应生成4-氯异硫氰酸苯酯
参考文献:New Potent Imidazoisoquinolinone Derivatives As Anti-Trypanosoma Cruzi Agents: Biological Evaluation And Structure-activity Relationships
标题:New Potent Imidazoisoquinolinone Derivatives As Anti-Trypanosoma Cruzi Agents: Biological Evaluation And Structure-activity Relationships
摘要:A Series Of Novel Benzoimidazo Andn-Aryl-5-Oxo-Imidazo[1,2-B] Isoquinoline-10-Carbothioamides Was Developed. All The Compounds Were Evaluated For Their In Vitro Action Against The Epimastigote Form Of Trypanosoma Cruzi. Four Of Them Showed Higher Activity Than Nifurtimox. Their Unspecific Cytotoxicity Was Evaluated Using Hela And L6 Cells,Being Non-Toxic At Concentrations At Least 15 And 200 Times Higher Than That Of T. Cruzi Ic50. To Gain Insight Into The Mechanism Of Action,Their Dna Binding Properties And Reactivity With Glutathione Were Studied,And Qsar Study Was Performed. (C) 2009 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmc.2009.01.011

专利信息

专利号:US-5585487-A
优先权日:1995-05-26
标题:Method for the preparation of β-thiolactam compound
发明人：OISHI AKIHIRO; TAGUCHI YOICHI; SHIBUYA ISAO; TSUCHIYA TOHRU
权利人:AGENCY IND SCIENCE TECHN
摘要:Disclosed is a method for the preparation of a beta -thiolactam compound, i.e. a 7-substituted-2-oxa-7-azabicyclo [3.2.0]-heptan-6-thione, represented by the general formula in which R is an alkyl or aryl group, having usefulness as an intermediate for the synthesis of various biologically active compounds. The compound can be prepared by the reaction of an isothiocyanate compound R-NCS, R being the same as above, and 2,3-dihydrofuran, preferably, under pressurization up to 2000 atmospheres or higher at an elevated temperature.

专利号:WO-2024177606-A1
优先权日:2023-02-24
标 题:Quinazolinone derivative compounds showing anti-cancer activity and the synthesis methods of these compounds
发明人：EVREN ASAF EVRIM; YURTTAS LEYLA; AKALIN CIFTCI GULSEN; SAGLIK BEGUM NURPELIN
权利人:BILECIK SEYH EDEBALI UNIV; ANADOLU UNIV
摘要:The invention relates to quinazolinone-derived compounds that show anticancer activity on the adenocarcinoma human alveolar basal epithelial cell line (A549) by inducing apoptosis in lung cancer cells through inhibition of the epidermal growth factor receptor (EGFR), and at the same time do not have any cytotoxic effects on healthy cells, and to the synthesis methods of these compounds The general structure of the compounds of the invention is shown by Formula (X).

专利号:CN-111471171-B
优先权日:2019-01-24
标 题:A kind of aryl sulfonic acid intermediate and its preparation method, and its application for the synthesis of low temperature sensitive admixture for concrete

专利号:RU-2057129-C1
优先权日:1989-05-31
标题:Method of synthesis of pyranyl-cyanoguanidine derivatives

专利号:US-12060336-B1
优先权日:2023-12-27
标题:(2E)-4-[(4-chlorophenyl)amino]-N-phenyl-2-(phenylimino)-1,3,5-dioxazepine-7-carboxamide as an eco-friendly insecticidal agent against Spodoptera littoralis (boisd.)
发明人：ALI MAI MOSTAFA KHALAF; GOUDA MOHAMED A; AHMED HANY MOHAMED ABD EL-LATEEF; AHMED ANTAR AHMED ABDELHAMID; GAD MOHAMED A
权利人:UNIV KING FAISAL
摘要:Synthesis of a compound (2E)-4-[(4-chlorophenyl)amino]-N-phenyl-2-(phenylimino)-1,3,5-dioxazepine-7-carboxamide and its use as an insecticidal agent.

专利号:US-11998014-B1
优先权日:2024-01-03
标题:O-{1-[(3,5-dinitrobenzoyl)amino]propan-2-yl} (4-chlorophenyl)carbamothioate as an eco-friendly insecticidal agent against Spodoptera littoralis (boisd.)
发明人：AHMED HANY MOHAMED ABD EL-LATEEF; ALI MAI MOSTAFA KHALAF; GOUDA MOHAMED; AHMED ANTAR AHMED ABDELHAMID; GAD MOHAMED A
权利人:UNIV KING FAISAL
摘要:Synthesis of a compound O-{1-[(3.5-dinitrobenzoyl)amino]propan-2-yl} (4-chlorophenyl)carbamothioate and its use as an insecticidal agent.