CAS: 22364-68-7; 2-(O-Tolyl)Acetonitrile

上下游产品

CAS号143-33-9 氰化钠 | CAS号552-45-4 邻甲基氯苄 | CAS号18293-53-3 (三甲硅基)乙腈 | CAS号95-46-5 2-溴甲苯 | CAS号84109-17-1 chlorozinc(1+),... | CAS号590-17-0 溴乙腈 | CAS号17729-59-8 Tributyl(cyanom... | CAS号89-92-9 2-甲基苄基溴 | CAS号928664-98-6 4-异恶唑硼酸频哪醇酯 | CAS号40851-62-5 邻甲苯乙酸甲酯 | CAS号40089-14-3 2-o-toluolacetamide | CAS号40291-39-2 邻甲苯乙酸乙酯 | CAS号142682-67-5 ethyl 2-(2-meth... | CAS号51052-00-7 邻甲基苯基丙酮 | CAS号186347-28-4 4-氰基-4-邻甲苯哌啶-1-羧酸叔丁酯 | CAS号577-16-2 2-甲基乙酰苯酮 | CAS号644-36-0 邻甲基苯乙酸 | CAS号55755-16-3 2-(邻甲苯基)乙胺 | CAS号102450-00-0 2-(2-METHYL-CYC...

1-甲基-2-(2-硝基乙基)苯置于sodium Hydroxide,偶氮二异丁腈,三正丁基氢锡,三乙胺,Sodium Nitrite体系中,用 甲醇,二氯甲烷,苯 用作溶剂,化学反应生成邻甲基苯乙腈
参考文献:通过硝酸和其酯从伯硝基化合物轻松合成腈
标题:通过硝酸和其酯从伯硝基化合物轻松合成腈
摘要:在催化量的aibn存在下,在回流的苯中,链烷烃基和芳基链烷烃硝酸酯与bu 3 Snh的反应以优异的收率提供了相应的腈.
Doi:10.1016/0040-4039(96)01779-0

专利信息

专利号:US-7420052-B2
优先权日:2001-08-24
标 题:Intermediates for synthesis of vinblastine, process for preparation of the intermediates and process for synthesis of vinblastines
发明人：FUKUYAMA TOHRU; TOKUYAMA HIDETOSHI; YOKOSHIMA SATOSHI
权利人:JAPAN SCIENCE & TECH AGENCY
摘要:An intermediate for vinblastine synthesis represented by general formula A. n ngeneral formula A.n n(in the formula, R 1 , R 2 , R 3 and R 4 are the group selected independently from the group consisting of H, lower alkyl group, lower alkoxy group, halogen, lower perfluoroalkyl group, lower alkylthio group, hydroxy group, amino group, mono- or di-alkyl or acylamino group, lower alkyl or arylsulfonyloxy group. R 5 is H, or a lower alkyl group or a substituted or non-substituted aryl group, R 6 is an alkyl group of carbon number 4 or less, R 7 is a substituted or non-substituted aryl group, R 8 is a substituted or non-substituted aryl group or lower alkyl group and R 9 is an acyl group or trialkylsilyl group.) A method for synthesis of the compound of general formula A utilizing radical ring forming reaction of thioanilides and using the compound of general formula B as the starting material, synthesizing thioanilide of general formula C by the reaction with compound 1 and the formation of a 11-membered ring by intramolecular alkylation of 2-nitrobenzenesulfonamide by which the reactions can proceed under mild conditions and high yield can be accomplished.

专利号:US-8026384-B2
优先权日:2007-05-04
标题:Process for the synthesis of alkyl phosphinic acids by initiation of an amine and an amineoxide
发明人：FINNHULT DANIEL; SOHLBERG ROGER; STALFORS FREDRIK; SVENSSON CARINA; WACHTMEISTER JOHANNA; WANNMAN THOMAS
权利人:ASTRAZENECA AB
摘要:The present invention relates to a new process for the synthesis of alkyl phosphinic acids, and more particularly to a coupling reaction between an alkylhalide and a hypophosphorous acid derivative in the presence of an amine and an amineoxide.

专利号:WO-2008136745-A1
优先权日:2007-05-04
标题:Process for the synthesis of alkyl phosphinic acids by initiation of an amine and an amineoxide
发明人：FINNHULT DANIEL; SOHLBERG ROGER; STAALFORS FREDRIK; SVENSSON CARINA; WACHTMEISTER JOHANNA; WAENNMAN THOMAS
权利人:ASTRAZENECA AB; FINNHULT DANIEL; SOHLBERG ROGER; STAALFORS FREDRIK; SVENSSON CARINA; WACHTMEISTER JOHANNA; WAENNMAN THOMAS
摘要:The present invention relates toa new process for the synthesis of alkyl phosphinic acids, and more particularly to a coupling reaction between an alkylhalide and a hypophosphorous acid derivative in the presence of an amine and an amineoxide.

专利号:US-8962858-B2
优先权日:2011-01-21
标题 :Methods and compounds useful in the synthesis of fused aminodihydrothiazine derivatives
发明人：MITASEV BRANKO; KIM DAE-SHIK; ZHANG HUIMING; FARTHING CHRISTOPHER N
权利人:EISAI R&D MAN CO LTD
摘要:Provided are compounds and methods useful for the preparation of compounds useful as inhibitors of beta-site amyloid precursor protein (APP)-cleaving enzyme.

专利号:US-5530124-A
优先权日:1994-06-30
标 题:Method for preparing cyclic ureas and their use for the synthesis of HIV protease inhibitors
发明人：RADESCA LILIAN A; HARRIS GREGORY D; WAT EDWARD K W; WALTERMIRE ROBERT E
权利人:DU PONT MERCK PHARMA
摘要:This invention provides improved synthetic processes for the preparation of hydroxy-protected cyclic urea compounds of Formula (IX), ##STR1## which are useful as intermediates for the preparation of cyclic urea human immunodeficiency virus (HIV) protease inhibitors, from N-protected aminoaldehydes. The processes of the present invention provide high yields, can be conducted on multikilogram scale, and eliminate the need for chromatographic purification of intermediates or final product.

专利号:US-7238802-B2
优先权日:2001-08-24
标题:Intermediates for synthesis of vinblastines, process for preparation of the intermediates and process for synthesis on vinblastines