CAS: 23142-01-0; Carbetapentane Citrate

1-苯基环戊烷羧酸置于4-二甲氨基吡啶,三光气体系中,用 丙酮,甲苯 用作溶剂,化学反应 11.0H,反应生成托可拉斯
参考文献:一种枸橼酸喷托维林的制备方法
标题:一种枸橼酸喷托维林的制备方法
摘要:本发明公开了一种枸橼酸喷托维林的制备方法,包括以下步骤:1)以甲苯作为反应溶剂,以dmap作为催化剂,1‑苯基环戊基甲酸与三氯甲基碳酸酯,在甲苯回流温度下进行酰化反应,得到1‑苯基环戊基甲酰氯;2)将2‑(2‑二乙氨基乙氧基)乙醇加入步骤1)的溶液中进行缩合反应,得到喷托维林盐酸盐,再经碱处理,得到喷托维林游离碱的浓缩液;3)将步骤2)所得的喷托维林浓缩液溶解在丙酮溶液中,加入无水柠檬酸进行成盐反应,得到枸橼酸喷托维林.本发明的枸橼酸喷托维林的制备方法,其产品质量好,收率高,原料易得,成本低,具有较高经济效益;且易操作,反应条件温和,副反应少,环境污染小,适合工业化生产.

专利信息

专利号:US-2005053642-A1
优先权日:2000-08-23
标题:Biocompatible materials
发明人：ULBRICHT MATHIAS; THOM VOLKMAR; JANKOVA KATJA; ALTANKOV GEORGE; JONSSON GUNNAR
摘要:The present invention teaches a novel approach of creating biocmpatible surfaces, said surfaces being capable of functionally interact with biological material. SAid biocompatible surfaces comrise at least two comonents, such as a hydrophobic substratum and a macromolecule of hydrophilic nature, which, in a cooperativity, form together the novel biocoompatible surfaces. The novel approach is ased on contacting said hydrophobic substratum with a laterally patterned monomolecular layer of said hydrophilic and flexible macromolecules, exhibiting a pronounced excluded volume. The htus formed two component surface is, in respect to polarity and morphology, a molecularly heterogeneous surface. Structural features of said macromolecular monolayer (as e.g. the layer thickness or its lateral density) are determined by: i) the structural features of the layer forming macromolecules (as e.g. their MW or their molecular architecture) and ii) the method of creating said monomolecular layer (as e.g. by physi- or chemisorbing, or by chemically binding said macromolecules). The structural features of the layer forming macromolecules(s) is in turn determined by synthesis. AMount and conformation and thus also biological activity of biological material (as e.g. polypeptides) which contact the novel biocompatible surface, is determined and maintained by the cooperative action of the underlying hydrophobic substratum and the macromolecular layer. In this way it becomes possible to maintain and control biological interactions between said contacted polypeptides and other biological compounds as e.g. cells, antibodies and the like. Consequently, the present invention aims to reduce and/or eliminate the deactivation and/or denaturation associated with the contacting of polypeptides and/or other biological material to a hydrophobic substratum surface.