CAS: 243666-12-8; 2-(2,3,4-Trifluorophenyl)Acetic Acid

专利信息

专利号:US-8476437-B2
优先权日:2008-08-27
标题:Process for preparation of (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro [1,2,4]-triazolo[4,3-a]pyrazin-7(8H)-yl]-l-(2,4,5-trifluorophenyl)butan-2-amine and new impurities in preparation thereof
发明人：KOTHARI HIMANSHU MADHUSUDAN; DAVE MAYANK GHANSHYAMBHAI; PANDEY BIPIN; SHUKLA BHAVIN SHRIPRASAD
权利人:KOTHARI HIMANSHU MADHUSUDAN; DAVE MAYANK GHANSHYAMBHAI; PANDEY BIPIN; SHUKLA BHAVIN SHRIPRASAD; CADILA HEALTHCARE LTD
摘要:The present invention relates to synthesis of β-amino acid derivatives of formula (I) and its salts of formula (Ia) by a novel process. The process comprises the reduction of a protected or unprotected prochiral β-amino acrylic acid or derivative there of, by using borane containing reducing agents at atmospheric pressure. The resulting racemic β-amino compound is resolved to a pure stereoisomer of formula (I), specifically to (2R)-4-oxo-4-[3-Ctrifluoromethyl)-5,6-dihydrol[1,2,4]triazolo[4,3-alpyrazin-7(8H)-yl]-1-(2,4,4-trifluorophenyl)butan-2-amine. In an embodiment the invention disclosed polymorphic forms of formula (I), phosphate salt of formula (I) and also a Dibenzoyl-L-tartaric acid salt of formula (I).

专利号:US-2004068141-A1
优先权日:2002-10-08
标 题 :Process for the synthesis of trifluorophenylacetic acids
发明人：ARMSTRONG JOSEPH D; DREHER SPENCER D; IKEMOTO NORIHIRO
摘要:The present invention addresses a process for the preparation of 2,4,5-trifluorophenylacetic acid using a Cu(I) salt as a catalyst.

专利号:US-6870067-B2
优先权日:2002-10-08
标 题 :Process for the synthesis of trifluorophenylacetic acids
发明人：IKEMOTO NORIHIRO; DREHER SPENCER D
权利人:MERCK & CO INC
摘要:The present invention is concerned with a process for the preparation of trifluorophenylacetic acids using a Grignard reagent and an allylating agent, such as allyl bromide.

专利号:EA-002100-B1
优先权日:1996-12-23
标题:CYCLOALCYL COMPOUNDS, LACTAMS, LACTONES AND RELATED COMPOUNDS CONTAINING THEIR PHARMACEUTICAL COMPOSITIONS AND METHODS OF INHIBITING THE SURVIVAL AND / OR SYNTHESIS OF β-AMYLOUS PEPTIDE SOFTWARE AGREED SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE AND SOFTWORK

专利号:WO-2004083212-A1
优先权日:2003-03-18
标 题:Process to beta-ketoamide intermediates to dipeptidyl peptidase inhibitors
发明人：IKEMOTO NORIHIRO; SIMMONS BRYON L; WILLIAMS J MICHAEL; XU FENG; YANG CHUNHUA
权利人:MERCK & CO INC; IKEMOTO NORIHIRO; SIMMONS BRYON L; WILLIAMS J MICHAEL; XU FENG; YANG CHUNHUA
摘要:A novel process is provided for the preparation of beta-ketoamide intermediates which are useful in the synthesis of dipeptidyl peptidase-IV inhibitors for the treatment of type 2 diabetes. Also provided are useful intermediates obtained from the process.

专利号:CN-102574856-B
优先权日:2009-05-11
标 题:The synthesis of sitagliptin