CAS: 2812-46-6; H-Pro-Otbu

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CAS号16881-39-3 N-Cbz-L-脯氨酸叔丁酯 | CAS号91237-84-2 (2S)-5-氧代-1,2-吡... | CAS号115-11-7 2-甲基丙烯 | CAS号147-85-3 脯氨酸 | CAS号5497-76-7 L-脯氨酸特丁酯盐酸盐 | CAS号1148-11-4 N-CBZ-L-脯氨酸 | CAS号81477-94-3 二苯亚甲基甘氨酸叔丁酯 | CAS号79640-72-5 (S)-5-甲基-2-氨基戊二酸叔丁酯 | CAS号217326-48-2 N-(3,5-二氯苯磺酰基)-l-脯氨酸 | CAS号7776-34-3 L-脯氨酸盐酸盐 | CAS号76095-16-4 马来酸依那普利 | CAS号62571-86-2 卡托普利 | CAS号5497-76-7 L-脯氨酸特丁酯盐酸盐 | CAS号75847-73-3 依那普利 | CAS号360045-22-3 1-(甲基磺酰基)-l-脯氨酸 | CAS号129223-22-9 N-芴甲氧羰基-脯氨酰-脯氨酸 | CAS号5874-58-8 N-苯甲酰基-l-脯氨酸

D-脯氨酸 反应生成D-脯氨酸叔丁酯
参考文献:D-Proline Derivatives
标题:D-Proline Derivatives
摘要:新化合物的化学式为:##str1## 其中r,R.Sup.1,X和y的含义如本文所述.本文提供了合成这些化合物和使用这些化合物治疗与淀粉样变性相关的疾病的方法,如阿尔茨海默病,成人起病糖尿病,家族性淀粉样多发性神经病,痱子病和克雅氏病.

专利信息

专利号:US-2009099061-A1
优先权日:2006-01-27
标 题:Synthesis of carotenoid analogs or derivatives with improved antioxidant characteristics
发明人：FOSS BENTE J; NADOLSKI GEOFFRY T; LOCKWOOD SAMUEL F
权利人:FOSS BENTE J; NADOLSKI GEOFFRY T; LOCKWOOD SAMUEL F
摘要:A method is described for synthesizing and administering carotenoid compounds with improved antioxidant characteristics. In some embodiments, extension or improvement of conjugation may be employed in structural modification of carotenoids. In other embodiments, reduction of ring/chain steric hindrance may improve the lambda max, and hence, the overall antioxidant capability, of particular compounds. In other embodiments, introduction and/or increase in synthetic handles for conjugation may improve the stoichiometric ratios of conjugating moieties to the polyene backbone. The methods may be used to improve natural and/or synthetic compounds for medicinal application in the treatment of disease.

专利号:US-6797820-B2
优先权日:1999-12-17
标 题:Succinate compounds, compositions and methods of use and preparation
发明人：PATEL DINESH; JACOBS JEFFREY W; JAIN RAKESH; NI ZHI-JIE; YUAN ZHENGYU
权利人:VICURON PHARM INC
摘要:Novel hydroxamic acid compounds are disclosed. These hydroxamates inhibit peptidyl deformylase (PDF), an enzyme present in prokaryotes. The hydroxymates are useful as antimicrobials and antibiotics. The compounds of the invention display selective inhibition of peptidyl deformylase versus other metalloproteinases such as matrix metalloproteinases (MMPs). Methods of synthesis and of use of the compounds are also disclosed.

专利号:WO-0144179-A1
优先权日:1999-12-17
标题 :Novel succinate compounds, compositions and methods of use and preparation
发明人：JAIN RAKESH; NI ZHI-JIE; PATEL DINESH V; YUAN ZHENGYU
权利人:VERSICOR INC; JACOBS JEFFREY W; JAIN RAKESH; NI ZHI JIE; PATEL DINESH V; YUAN ZHENGYU
摘要:Novel hydroxamic acid compounds of Formula (I) are disclosed. These hydroxamates inhibit peptide deformylase (PDF), an enzyme present in prokaryotes. The hydroxymates are useful as antimicrobials and antibiotics. The compounds of the invention display selective inhibition of peptidyl deformylase versus other metalloproteinases such as matrix metalloproteinases (MMPs). Methods of synthesis and of use of the compounds are also disclosed.

专利号:US-8338565-B2
优先权日:2008-08-20
标 题 :Macrocyclic compounds for inhibition of tumor necrosis factor alpha
发明人：LEE JINBO; BOND JULIAN F; TERRETT NICHOLAS; FAVALORO JR FRANK G; WANG DANIEL; BRIGGS TIMOTHY F; SEIGAL BENJAMIN ADAM; SUN WEI-CHUAN; HALE STEPHEN P
权利人:LEE JINBO; BOND JULIAN F; TERRETT NICHOLAS; FAVALORO JR FRANK G; WANG DANIEL; BRIGGS TIMOTHY F; SEIGAL BENJAMIN ADAM; SUN WEI-CHUAN; HALE STEPHEN P; ENSEMBLE THERAPEUTICS CORP
摘要:Disclosed herein are macrocyclic compounds and methods for their synthesis and use. In particular, macrocyclic compounds are disclosed that modulate the activity of tumor necrosis factor alpha and/or are useful in the treatment of medical conditions, such as, rheumatoid arthritis, psoriasis, and asthma.

专利号:US-6852752-B2
优先权日:1999-12-17
标 题:Urea compounds, compositions and methods of use and preparation
发明人：JACOBS JEFFREY W; PATEL DINESH; LEWIS JASON; NI ZHI-JIE
权利人:VICURON PHARM INC
摘要:Novel hydroxamic acid compounds are disclosed. These hydroxamates inhibit peptide deformylase (PDF), an enzyme present in prokaryotes and are therefore useful as antimicrobials and antibiotics. Methods of synthesis and of use of the compounds are also disclosed.

专利号:CN-107840850-A
优先权日:2017-09-30
标 题 :A large-scale synthesis and preparation method of (±)-macahydantoin revised B