CAS: 50508-66-2; (2-Amino-4,5-Dimethylthiophen-3-yl)(4-Chlorophenyl)Methanone

上下游产品

CAS号78-93-3 甲乙酮 | CAS号4640-66-8 4-氯苯甲酰乙腈 | CAS号1268524-70-4 (+)-JQ1

2,4'-二氯苯乙酮置于吗啉,Sulfur体系中,用 乙醇,水 作为反应溶剂,化学反应 22.0H,反应生成 (2-氨基-4,5-二甲基-3-噻吩)(4-氯苯基)甲酮
参考文献: Bromodomain-Inhibiting Compounds And Pharmaceutical Composition Comprising Same For Preventing Or Treating A Cancer[fr] Composés Inhibiteurs De Bromodomaine Et Composition Pharmaceutique Les Comprenant Pour Prévenir Ou Traiter Un Cancer
标题: Bromodomain-Inhibiting Compounds And Pharmaceutical Composition Comprising Same For Preventing Or Treating A Cancer[fr] Composés Inhibiteurs De Bromodomaine Et Composition Pharmaceutique Les Comprenant Pour Prévenir Ou Traiter Un Cancer
摘要:提供了一种具有溴结构域和额外末端结构域(bet)蛋白抑制活性的新化合物,以及包含该化合物的药物组合物,可用于预防或治疗癌前病变或癌症.

专利信息

专利号:US-11267820-B2
优先权日:2015-09-09
标 题 :Tricyclic fused pyridin-2-one derivatives and their use as BRD4 inhibitors
发明人：VADIVELU SARAVANAN; RAJAGOPAL SRIDHARAN; RAMAIAH MANJUNATHA M; GONDRALA PAVAN KUMAR; CHINNAPATTU MURUGAN; SIVANANDHAN DHANALAKSHMI; PARIKH PAYAL KIRAN; MULAKALA CHANDRIKA
权利人:JUBILANT BIOSYS LTD
摘要:The present disclosure describes heterocyclic compounds of Formula I or, its stereoisomers, pharmaceutically acceptable salts, complexes, hydrates, solvates, tautomers, polymorphs, racemic mixtures, optically active forms and pharmaceutically active derivatives thereof and pharmaceutical compositions containing them as the active ingredient. The present disclosure also describes the synthesis and characterization of aforementioned compounds to exhibit high anticancer activity. The compounds of the present disclosure are useful as medicaments and their use in the manufacture of medicaments for treatment, prevention, or suppression of diseases, an conditions mediated b one or more BET family of bromodomains.